ATE202580T1 - Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen - Google Patents

Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen

Info

Publication number
ATE202580T1
ATE202580T1 AT93308457T AT93308457T ATE202580T1 AT E202580 T1 ATE202580 T1 AT E202580T1 AT 93308457 T AT93308457 T AT 93308457T AT 93308457 T AT93308457 T AT 93308457T AT E202580 T1 ATE202580 T1 AT E202580T1
Authority
AT
Austria
Prior art keywords
pharmaceutical preparations
antimicrobial polymers
preservatives
pharmaceutical
moieties
Prior art date
Application number
AT93308457T
Other languages
English (en)
Inventor
Joonsup Park
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE202580T1 publication Critical patent/ATE202580T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02Amines; Quaternary ammonium compounds
    • A01N33/12Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/30Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the groups —CO—N< and, both being directly attached by their carbon atoms to the same carbon skeleton, e.g. H2N—NH—CO—C6H4—COOCH3; Thio-analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143Quaternary ammonium compounds
    • A61L12/145Polymeric quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/0206Polyalkylene(poly)amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT93308457T 1992-11-04 1993-10-22 Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen ATE202580T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/971,424 US5300287A (en) 1992-11-04 1992-11-04 Polymeric antimicrobials and their use in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ATE202580T1 true ATE202580T1 (de) 2001-07-15

Family

ID=25518371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93308457T ATE202580T1 (de) 1992-11-04 1993-10-22 Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen

Country Status (9)

Country Link
US (1) US5300287A (de)
EP (1) EP0596631B1 (de)
JP (2) JP3353423B2 (de)
AT (1) ATE202580T1 (de)
AU (1) AU660377B2 (de)
CA (1) CA2102282C (de)
DE (1) DE69330381T2 (de)
ES (1) ES2157916T3 (de)
MX (1) MX9306735A (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760261A (en) * 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US6197529B1 (en) * 1990-11-21 2001-03-06 Torrey Pines Institute For Molecular Studies Linear substituted oligoalkyleneimine libraries
US5683709A (en) * 1994-05-05 1997-11-04 Ciba Vision Corporation Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions
US5536494A (en) * 1994-10-04 1996-07-16 Alcon Laboratories, Inc. Polyethylene oxide-containing quaternary ammunium polymers and pharmaceutical compositions containing an antimicrobial amount of same
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
DE19608555A1 (de) * 1996-03-06 1997-09-11 Basf Ag Verwendung von Polymerisaten als Biozid
US6034129A (en) 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
DE19654897A1 (de) * 1996-11-14 1998-06-04 Roehm Gmbh Monomere für Polymere mit antimikrobiellen Eigenschaften
US6290947B1 (en) 1997-09-19 2001-09-18 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin-binding agents
US6482402B1 (en) 1999-05-13 2002-11-19 Geltex Pharmaceuticals, Inc. Antimicrobial compositions and methods
US6372934B1 (en) * 2000-01-18 2002-04-16 Biosil Research Institute Water soluble complexes
US6461598B1 (en) * 2000-01-18 2002-10-08 Biosil Research Institute Inc. Process for conditioning hair
DE60109742T2 (de) 2000-01-25 2005-08-18 Alcon Inc. Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen
US20030021761A1 (en) * 2001-01-18 2003-01-30 Geltex Pharmaceuticals, Inc. Ionene polymers and their use in treating mucositis
DE10205923A1 (de) * 2002-02-12 2003-08-21 Creavis Tech & Innovation Gmbh Wasch- und Reinigungsformulierungen mit antimikrobiellen Polymeren
EP1501473A2 (de) * 2002-04-16 2005-02-02 Cosmetica, Inc. Polymere geruchsabsorbierende inhaltsstoffe für hygieneprodukte
US20040166753A1 (en) * 2002-06-10 2004-08-26 Millward Dan B. Modification of fabric fibers
CA2504898A1 (en) * 2002-11-05 2004-05-27 Nano-Tex, Llc Odor-absorbing cellulosic fibrous substrates
WO2004046109A2 (en) * 2002-11-19 2004-06-03 Genzyme Corporation Ionene oligomers and polymers
SE0403216D0 (sv) * 2004-12-30 2004-12-30 Appeatex Ab Antimicrobial product
WO2007024973A1 (en) * 2005-08-22 2007-03-01 Quick-Med Technologies, Inc. Disinfectant with quaternary ammonium polymers and copolymers
JP2009524719A (ja) * 2006-01-27 2009-07-02 チバ ホールディング インコーポレーテッド ポリマー状抗菌剤
AU2007264041B2 (en) * 2006-06-26 2011-07-07 Novartis Ag Polymers with antimicrobial activity containing quaternary ammonium groups
US8778321B2 (en) * 2007-10-01 2014-07-15 Nanotex Llc Modification of cellulosic substrates to control body odor
TWI544927B (zh) 2008-03-17 2016-08-11 愛爾康研究有限公司 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
US20090232763A1 (en) 2008-03-17 2009-09-17 Kabra Bhagwati P Aqueous pharmaceutical compositions containing borate-polyol complexes
CA2723954A1 (en) * 2008-05-19 2009-11-26 Alcon Research, Ltd. Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
CA2725103C (en) * 2008-05-29 2016-05-24 Dsm Ip Assets B.V. Antimicrobial polymers and their uses
US8093352B2 (en) * 2008-08-05 2012-01-10 Alcon Research, Ltd. Polyalkylene oxide polyquaternary ammonium biocides
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
US20100197702A1 (en) * 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same
WO2010101989A1 (en) * 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
US20100226992A1 (en) * 2009-03-03 2010-09-09 Alcon Research, Ltd. Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye
TW201038295A (en) * 2009-04-17 2010-11-01 Alcon Res Ltd Aqueous ophthalmic compositions containing anionic therapeutic agents
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸-多元醇錯合物之水性藥學組成物
US20100086514A1 (en) * 2009-10-01 2010-04-08 Liu X Michael Contact Lens Care Solutions with a Low Molecular Weight Oligomer
TWI478730B (zh) 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
CA2833591A1 (en) 2011-04-22 2012-10-26 Alcon Research, Ltd. Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents
JP2014512387A (ja) 2011-04-22 2014-05-22 アルコン リサーチ, リミテッド 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠(olopatadine)眼用組成物
TW201336527A (zh) 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
KR102225415B1 (ko) 2013-01-24 2021-03-08 보오슈 앤드 롬 인코포레이팃드 천연 왁스의 폴리(질소/아민) 유도체 및 안과용 조성물
CN104968198B (zh) * 2013-02-01 2018-02-13 禾大国际股份公开有限公司 自消毒表面
US10174006B2 (en) 2013-06-06 2019-01-08 Novartis Ag Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
AT515029B1 (de) * 2013-10-21 2015-12-15 Polymer Competence Ct Leoben Kontaktbiozide auf Basis von Poly(oxazin)en, Poly(oxazpein)en und Poly(oxazozin)en
TW201938141A (zh) 2018-02-21 2019-10-01 瑞士商諾華公司 基於脂質的眼用乳劑
US11364253B2 (en) 2018-07-02 2022-06-21 Ayuvis Research, Inc. Immunodulating small molecules
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
EP3924345A1 (de) 2019-02-15 2021-12-22 Novartis AG Kristalline formen von 4-(7-hydroxy-2-isopropyl-4-oxo-4h-chinazolin-3-yl)-benzonitril und deren formulierungen
CN116419918A (zh) 2020-08-06 2023-07-11 诺华股份有限公司 4-(7-羟基-2-异丙基-4-氧代-4h-喹唑啉-3-基)-苄腈的结晶形式及其配制品
WO2024062389A1 (en) 2022-09-21 2024-03-28 Bausch + Lomb Ireland Limited Crystalline polymorph forms of a trpv1 antagonist and formulations thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539684A (en) * 1968-11-21 1970-11-10 Calgon C0Rp Bactericidal polymers
US3898336A (en) * 1970-05-11 1975-08-05 California Inst Of Techn Insoluble polymeric quaternary trihalogen salt coated substrates
US3778476A (en) * 1970-05-11 1973-12-11 California Inst Of Techn Polymeric organic halogen salts
US4032293A (en) * 1974-09-09 1977-06-28 The United States Of America As Represented By The Secretary Of Agriculture Preparation of stable strong base cellulosic anion exchangers with red-ox potentials
US4012446A (en) * 1974-10-29 1977-03-15 Millmaster Onyx Corporation Capped polymers
US3931319A (en) * 1974-10-29 1976-01-06 Millmaster Onyx Corporation Capped polymers
US4001432A (en) * 1974-10-29 1977-01-04 Millmaster Onyx Corporation Method of inhibiting the growth of bacteria by the application thereto of capped polymers
GB1556365A (en) * 1976-08-11 1979-11-21 British Petroleum Co Antiviral agents
US4325940A (en) * 1976-11-24 1982-04-20 Kewanee Industries, Inc. Anti-microbial, cosmetic and water-treating ionene polymeric compounds
JPS5533411A (en) * 1978-08-29 1980-03-08 Mitsubishi Chem Ind Ltd Agent for controlling plant viral disease
US4250269A (en) * 1979-11-26 1981-02-10 Buckman Laboratories, Inc. Water-soluble mixtures of quaternary ammonium polymers, nonionic and/or cationic vinyl-addition polymers, and nonionic and/or cationic surfactants
US4499077A (en) * 1981-02-03 1985-02-12 Stockel Richard F Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects
US4654208A (en) * 1983-03-01 1987-03-31 Stockel Richard F Anti-microbial compositions comprising an aqueous solution of a germicidal polymeric nitrogen compound and a potentiating oxidizing agent
US4836986A (en) * 1984-09-28 1989-06-06 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
CA1259542A (en) * 1984-09-28 1989-09-19 Francis X. Smith Disinfecting and preserving solutions for contact lenses and methods of use
US5071934A (en) * 1987-12-21 1991-12-10 Exxon Research And Engineering Company Cationic hydrophobic monomers and polymers
US5104649A (en) * 1988-05-11 1992-04-14 Monsanto Company Surface-functionalized biocidal polymers
DE3843194A1 (de) * 1988-12-22 1990-07-12 Hoechst Ag Amphiphile monomere mit gemischtkettiger struktur und polymere und film aus mindestens einer monomolekularen schicht daraus
EP0457756B1 (de) * 1989-02-07 1995-04-26 Abb Fläkt Aktiebolag Laufrad-antriebswellenbefestigungsvorrichtung
US4960590A (en) * 1989-02-10 1990-10-02 Buckman Laboratories International, Inc. Novel polymeric quaternary ammonium trihalides
BE1002830A5 (fr) * 1989-02-15 1991-06-25 Fabricom Air Conditioning Sa Composition desinfectante et/ou de conservation et procede de desinfection et/ou de conservation d'aliments.
SE463223B (sv) * 1989-02-17 1990-10-22 Svenska Rotor Maskiner Ab Skruvrotormaskin med ljuddaempare
US5171526A (en) * 1990-01-05 1992-12-15 Allergan, Inc. Ophthalmic compositions and methods for preserving and using same
US5145643A (en) * 1990-01-05 1992-09-08 Allergan, Inc. Nonoxidative ophthalmic compositions and methods for preserving and using same

Also Published As

Publication number Publication date
DE69330381T2 (de) 2001-10-11
EP0596631A3 (de) 1996-07-03
CA2102282A1 (en) 1994-05-05
MX9306735A (es) 1994-06-30
JP3353423B2 (ja) 2002-12-03
CA2102282C (en) 1997-12-30
JPH06239997A (ja) 1994-08-30
ES2157916T3 (es) 2001-09-01
DE69330381D1 (de) 2001-08-02
AU660377B2 (en) 1995-06-22
EP0596631B1 (de) 2001-06-27
JP2002348338A (ja) 2002-12-04
EP0596631A2 (de) 1994-05-11
AU5032793A (en) 1994-05-19
US5300287A (en) 1994-04-05

Similar Documents

Publication Publication Date Title
ATE202580T1 (de) Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen
PT731714E (pt) Utilizacao de compostos quaternarios de amonio polimericos contendo oxido de polietileno em composicoes farmaceuticas
FI971033A0 (fi) Metoder foer infoerande av material i huden, samt daerfoer anvaenda kompositioner
IT8919413A0 (it) Composizione avente attivita&#39; battericida oppure batteriostatica.
DE69700024T2 (de) Ein bildendes Polymer und eine amphoterische Stärke enthaltende kosmetische Zusammensetzung
DE69228492D1 (de) 3,4,N-Trisubstituierte-4,5-dihydro-1H-Pyrazol-1-carboxamide und deren Anwendung als Insektizide
ATE47853T1 (de) 5,6-difluornaphtyridine und 5,6,8trifluorchinoline verwendbar als antibakterielle mittel.
IT9019754A0 (it) Composizioni farmaceutiche,dietetiche o veterinarie ad attivita&#39; eumetabolica
DE69322075D1 (de) Zusammensetzungen
ATE131164T1 (de) 2-(rs)-substituierte-2,3-dihydro-5-oxy-4,6,7- trimethyl-benzofurane, verwendbar als antioxydante arzneimittel mit mukoregulierender und anti-ischemischer wirkung.
ITMI940610A0 (it) Platino complessi cationici trinucleari ad attivita&#39; antitumorale e composizioni farmaceutiche che li contengono
ATE90510T1 (de) Antimikrobische zusammensetzung und deren verwendung.
IT1240683B (it) Composizione farmaceutica contenente egf
DE59003130D1 (de) Mikrobizid-Formulierungen und deren Verwendung.
DE68916211D1 (de) Guanidin- und Amidin-Verbindungen, deren Herstellung und Verwendung als Fungizide.
DE58902161D1 (de) Diorganozinn-verbindungen und diese enthaltende mittel mit bakterizider und fungizider wirkung.
ES2126580T3 (es) Proteina condromodulina-ii.
IT8921412A0 (it) Bacillus thuringiensis var. donegani, preparato o tossina da esso ottenuta aventi attivita&#39; insetticida contro i coleotteri.
DE69226171D1 (de) Zusammensetzung und verwendung von substituierten 1,3-dithiolo- und 1,4-dithiino-chinoxalinen als antimikrobielle mittel
IT1216096B (it) L_piroglutamil_l_cisteina, dipeptide ad elevata attivita&#39;anticatarattogena e composizioni farmaceutiche che lo contengono.
ATE90511T1 (de) Herbizide mittel.
DE69205155D1 (de) Zusammensetzung und Verwendung von Dimucapto-substituierten Dinitrilen als antimikrobielle Mittel.
DE69325083T2 (de) Imidazol-Derivate und ihre Verwendung als agrochemische Mittel
ITMI930453A1 (it) Composizione farmaceutica avente attivita&#39; antiasmatica
IT8921468A0 (it) Composti otticamente attivi aventi attivita&#39; vasodilatatrici periferica, e loro composizioni farmaceutiche.