ATE195739T1 - Kondensierte purinderivate - Google Patents

Kondensierte purinderivate

Info

Publication number: ATE195739T1
Authority: AT; Austria
Prior art keywords: alkyl; represents hydrogen; lower alkyl; purine derivatives; condensed purine
Prior art date: 1989-10-20

Application number

AT90120056T

Other languages

English (en)

Inventor

Fumio Suzuki

Junichi Shimada

Takeshi Kuroda

Kazuhiro Kubo

Akira Karasawa

Tetsuji Ohno

Kenji Ohmori

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-20

Filing date

1990-10-19

Publication date

2000-09-15

1990-10-19 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195739T1 publication Critical patent/ATE195739T1/de

Links

229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 2
150000003212 purines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
208000001953 Hypotension Diseases 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004342 dicyclopropylmethyl group Chemical group [H]C1([H])C([H])([H])C1([H])C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
229940030606 diuretics Drugs 0.000 abstract 1
208000021822 hypotensive Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000003223 protective agent Substances 0.000 abstract 1
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
125000005504 styryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90120056T 1989-10-20 1990-10-19 Kondensierte purinderivate ATE195739T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP27340389		1989-10-20

Publications (1)

Publication Number	Publication Date
ATE195739T1 true ATE195739T1 (de)	2000-09-15

Family

ID=17527409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90120056T ATE195739T1 (de)	1989-10-20	1990-10-19	Kondensierte purinderivate

Country Status (7)

Country	Link
US (1)	US5270316A (de)
EP (1)	EP0423805B1 (de)
JP (1)	JP2988711B2 (de)
AT (1)	ATE195739T1 (de)
CA (1)	CA2028235C (de)
DE (1)	DE69033614T2 (de)
ES (1)	ES2152207T3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5338743A (en) *	1988-06-06	1994-08-16	Fujisawa Pharmaceutical Co., Ltd.	New use of the adenosine antagonist
NZ238609A (en) *	1990-06-21	1993-12-23	Schering Corp	Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
US5756735A (en) *	1990-10-18	1998-05-26	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
WO1992006976A1 (fr) *	1990-10-18	1992-04-30	Kyowa Hakko Kogyo Co., Ltd.	Derive de xanthine
US5442062A (en) *	1991-10-24	1995-08-15	The Upjohn Company	Imidazole derivatives and pharmaceutical compositions containing the same
CA2112031A1 (en) *	1992-12-24	1994-06-25	Fumio Suzuki	Xanthine derivatives
EP0686157A1 (de) *	1993-02-26	1995-12-13	Schering Corporation	2-benzylpolycyclisch guaninderivate und verfahren zu ihrer herstellung
WO1994025462A1 (en) *	1993-05-03	1994-11-10	The United States Of America, Represented By The	8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
CA2206287C (en)	1994-12-13	2001-03-20	Mark Chasin	Aryl thioxanthines
US5824683A (en) *	1995-11-28	1998-10-20	Schering Corporation	2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
US6294541B1 (en)	1996-06-06	2001-09-25	Euro-Celtique S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
AU4471297A (en)	1996-10-07	1998-05-05	Kyowa Hakko Kogyo Co. Ltd.	Fused purine derivatives
AU1722899A (en)	1997-12-12	1999-07-05	Euro-Celtique S.A.	Preparation of 3-substituted adenines
US6489331B1 (en)	1998-07-02	2002-12-03	Kyowa Hakko Kogyo Co., Ltd.	Remedies for diabetes
US6319928B1 (en) *	1998-11-30	2001-11-20	Euro-Celtique, S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
JP2002541078A (ja)	1999-04-02	2002-12-03	ユーロ−セルティーク，エス．エー．	ホスホジエステラーゼｉｖ阻害活性を有するプリン誘導体
AU784528B2 (en) *	1999-11-12	2006-04-27	Biogen Idec Ma Inc.	Adenosine receptor antagonists and methods of making and using the same
JP2003513982A (ja)	1999-11-12	2003-04-15	バイオジェンインコーポレイテッド	アデノシンレセプターアンタゴニストとしてのポリシクロアルキルプリン
WO2001047931A1 (fr) *	1999-12-24	2001-07-05	Kyowa Hakko Kogyo Co., Ltd.	Derives de purine fondue
US7087589B2 (en) *	2000-01-14	2006-08-08	The United States Of America As Represented By The Department Of Health And Human Services	Methanocarba cycloakyl nucleoside analogues
UA75625C2 (en) *	2000-12-01	2006-05-15	Biogen Inc	Condensed purine derivatives as a1 adenosine receptor antagonists
US6423844B1 (en)	2001-06-06	2002-07-23	The United States Of America As Represented By The Secretary Of The Navy	Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
KR20060005376A (ko) *	2003-04-25	2006-01-17	교와 핫꼬 고교 가부시끼가이샤	축합 피리미딘 유도체
US20070196340A1 (en) *	2003-05-06	2007-08-23	Aldo Ammendola	Modulation of Pathogenicity
RU2015105591A (ru)	2008-06-10	2015-08-10	Эббви Инк.	Новые трициклические соединения
SG181147A1 (en)	2009-12-01	2012-07-30	Abbott Lab	Novel tricyclic compounds
DK2506716T3 (en)	2009-12-01	2017-09-04	Abbvie Inc	HIS UNKNOWN TRICYCLIC RELATIONS
WO2011068978A1 (en)	2009-12-02	2011-06-09	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methanocarba adenosine derivatives and dendrimer conjugates thereof
JP2017527606A (ja) *	2014-09-18	2017-09-21	サノビオンファーマシューティカルズインクＳｕｎｏｖｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	三環系誘導体
US11780848B2 (en)	2015-10-16	2023-10-10	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
US10550126B2 (en)	2015-10-16	2020-02-04	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en)	2015-10-16	2022-12-13	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
EP4219503A1 (de)	2015-10-16	2023-08-02	AbbVie Inc.	Kristallines l-maleat von (3s,4r)-3-ethyl-4-(3h-imidazo[1,2-a!pyrrolo[2,3-e!pyrazin-8-yl)-n-(2,2,2-trifluorethyl)pyrrolidin-1-carboxamid
US11512092B2 (en)	2015-10-16	2022-11-29	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en)	2015-10-16	2022-06-21	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
CN114106000B (zh) *	2021-12-15	2023-11-24	中国科学院新疆理化技术研究所	一种咪唑并[4,5-d]嘧啶酮三环类衍生物及抗肿瘤用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE863525A (fr) *	1977-02-14	1978-07-31	Bristol Myers Co	Heterocyclopyrimidines
CA1095906A (en) *	1977-02-14	1981-02-17	Davis L. Temple, Jr.	Heterocyclopyrimidines, compositions and therapeutic process
SE7810946L (sv)	1978-10-20	1980-04-21	Draco Ab	Metod att behandla kronisk obstruktiv luftvegssjukdom
US4870181A (en)	1985-02-04	1989-09-26	A. H. Robins Company, Incorporated	Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides
US4710503A (en)	1985-02-07	1987-12-01	Euroceltique S.A.	6-thioxanthine derivatives
US5086176A (en) *	1989-03-29	1992-02-04	Merrell Dow Pharmaceuticals Inc.	Tricyclic fused adenine derivatives
US5064947A (en) *	1989-03-29	1991-11-12	Merrell Dow Pharmaceuticals Inc.	Selective adenosine reseptor compounds
AU623755B2 (en) *	1989-03-29	1992-05-21	Merrell Pharmaceuticals Inc.	Selective adenosine receptor compounds
JP2980658B2 (ja) *	1989-09-14	1999-11-22	協和醗酵工業株式会社	ｓ―トリアゾロ〔３，４―ｉ〕プリン誘導体

1990
- 1990-10-19 EP EP90120056A patent/EP0423805B1/de not_active Expired - Lifetime
- 1990-10-19 DE DE69033614T patent/DE69033614T2/de not_active Expired - Fee Related
- 1990-10-19 US US07/599,758 patent/US5270316A/en not_active Expired - Fee Related
- 1990-10-19 JP JP28157890A patent/JP2988711B2/ja not_active Expired - Fee Related
- 1990-10-19 CA CA002028235A patent/CA2028235C/en not_active Expired - Fee Related
- 1990-10-19 ES ES90120056T patent/ES2152207T3/es not_active Expired - Lifetime
- 1990-10-19 AT AT90120056T patent/ATE195739T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH03204880A (ja)	1991-09-06
EP0423805B1 (de)	2000-08-23
ES2152207T3 (es)	2001-02-01
EP0423805A3 (en)	1992-01-02
DE69033614D1 (de)	2000-09-28
JP2988711B2 (ja)	1999-12-13
CA2028235C (en)	1997-01-21
US5270316A (en)	1993-12-14
DE69033614T2 (de)	2001-04-19
CA2028235A1 (en)	1991-04-21
EP0423805A2 (de)	1991-04-24

Legal Events

Date	Code	Title	Description
2001-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69033614D1 (de)	2000-09-28	Kondensierte Purinderivate
NO302755B1 (no)	1998-04-20	Morfinan-derivater
ES2091212T3 (es)	1996-11-01	Compuestos de xantina.
NO2006018I2 (no)	2008-10-20	Entekavir
DK0386675T3 (da)	1996-06-24	Xanthinderivater
DK232989A (da)	1989-11-14	Antiviralt praeparat
NO934536L (no)	1994-07-01	Fenoksy- og fenoksyalkyl-pepiridiner som antivirale midler
ATE45354T1 (de)	1989-08-15	Chinoloncarbonsaeurederivate.
ES2150613T3 (es)	2000-12-01	Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.
NO921159L (no)	1992-09-28	Tiazolidinon- og oksazolidinonderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som vasodilatorer
DE69029303D1 (de)	1997-01-16	5-Triazolo(3,4-i)purinderivate
ATE55057T1 (de)	1990-08-15	Zentralwirkende muskelrelaxante.
DK0654473T3 (da)	2000-03-20	Cyclopropanderivater og antivirale midler med indhold deraf
ATE105565T1 (de)	1994-05-15	Pradimicinderivate.
ES2109962T3 (es)	1998-02-01	Derivados de la naftiridina condensados.
FI883507A0 (fi)	1988-07-26	Naftotiazepinderivat och deras framstaellning.
ES527115A0 (es)	1985-05-01	Derivados de benzo (f) quinolina