ATE189682T1 - Prohormonspaltungsplatzblockierungsantikörper - Google Patents
ProhormonspaltungsplatzblockierungsantikörperInfo
- Publication number
- ATE189682T1 ATE189682T1 AT90913016T AT90913016T ATE189682T1 AT E189682 T1 ATE189682 T1 AT E189682T1 AT 90913016 T AT90913016 T AT 90913016T AT 90913016 T AT90913016 T AT 90913016T AT E189682 T1 ATE189682 T1 AT E189682T1
- Authority
- AT
- Austria
- Prior art keywords
- prohormone
- blocking antibodies
- place blocking
- cleavage place
- prohormone cleavage
- Prior art date
Links
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 title abstract 2
- 230000007017 scission Effects 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Luminescent Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39525489A | 1989-08-16 | 1989-08-16 | |
PCT/US1990/004536 WO1991002756A1 (en) | 1989-08-16 | 1990-08-13 | Prohormone cleavage site blocking antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE189682T1 true ATE189682T1 (de) | 2000-02-15 |
Family
ID=23562288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90913016T ATE189682T1 (de) | 1989-08-16 | 1990-08-13 | Prohormonspaltungsplatzblockierungsantikörper |
Country Status (8)
Country | Link |
---|---|
US (3) | US5677182A (de) |
EP (1) | EP0487610B1 (de) |
JP (1) | JPH05501351A (de) |
AT (1) | ATE189682T1 (de) |
AU (1) | AU641178B2 (de) |
CA (1) | CA2023250A1 (de) |
DE (1) | DE69033457T2 (de) |
WO (1) | WO1991002756A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0614984T4 (da) * | 1993-03-05 | 2010-12-20 | Bayer Healthcare Llc | Humane monoklonale anti-TNF-alfa-antistoffer |
EP0657469A1 (de) * | 1993-10-26 | 1995-06-14 | Boehringer Ingelheim Pharmaceuticals Inc. | L-Selektinspaltungsplatz, Verfahren zur Diagnose une ihre Verwendung |
US6406901B1 (en) | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
US5830742A (en) * | 1995-06-08 | 1998-11-03 | Immunex Corporation | TNF-α converting enzyme |
IL122305A0 (en) * | 1995-06-08 | 1998-04-05 | Immunex Corp | Tace polypeptide its production and its use |
IL114461A0 (en) * | 1995-07-05 | 1995-11-27 | Yeda Res & Dev | TNF modulation |
CN1310675C (zh) * | 1995-07-20 | 2007-04-18 | 依默耐克斯有限公司 | TNF-α转变酶 |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
RU2377253C2 (ru) | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
JP4769456B2 (ja) * | 2004-12-27 | 2011-09-07 | 昭和シェル石油株式会社 | ウレア系潤滑グリース組成物、転がり軸受けおよび電動パワーステアリング装置 |
SG182170A1 (en) | 2007-06-06 | 2012-07-30 | Domantis Ltd | Polypeptides, antibody variable domains and antagonists |
KR101806567B1 (ko) | 2009-02-19 | 2018-01-10 | 메르츠 파마 게엠베하 운트 코. 카가아 | 매우 순수한 신경독을 제조하기 위한 수단 및 방법 |
WO2010124998A1 (en) * | 2009-04-27 | 2010-11-04 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4870163A (en) * | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
DE3631229A1 (de) * | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
EP0288088B1 (de) * | 1987-04-24 | 1994-03-09 | Teijin Limited | Bestimmung vom Tumornekrosefaktor; monoklonaler Antikörper und Zusammensetzung |
WO1990000902A1 (en) * | 1988-07-18 | 1990-02-08 | Chiron Corporation | Monoclonal antibodies reactive with cachectin |
CA2064915C (en) * | 1989-08-07 | 2001-05-29 | Deborah A. Rathjen | Tumour necrosis factor binding ligands |
-
1990
- 1990-08-13 DE DE69033457T patent/DE69033457T2/de not_active Expired - Lifetime
- 1990-08-13 EP EP90913016A patent/EP0487610B1/de not_active Expired - Lifetime
- 1990-08-13 JP JP2511902A patent/JPH05501351A/ja active Pending
- 1990-08-13 WO PCT/US1990/004536 patent/WO1991002756A1/en active IP Right Grant
- 1990-08-13 AT AT90913016T patent/ATE189682T1/de active
- 1990-08-13 AU AU62765/90A patent/AU641178B2/en not_active Ceased
- 1990-08-14 CA CA002023250A patent/CA2023250A1/en not_active Abandoned
-
1995
- 1995-04-18 US US08/424,243 patent/US5677182A/en not_active Expired - Fee Related
- 1995-06-05 US US08/463,894 patent/US5686259A/en not_active Expired - Fee Related
- 1995-06-05 US US08/463,892 patent/US5702705A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69033457D1 (en) | 2000-03-16 |
EP0487610A1 (de) | 1992-06-03 |
CA2023250A1 (en) | 1991-02-16 |
US5702705A (en) | 1997-12-30 |
AU641178B2 (en) | 1993-09-16 |
US5686259A (en) | 1997-11-11 |
EP0487610B1 (de) | 2000-02-09 |
DE69033457T2 (de) | 2000-09-14 |
WO1991002756A1 (en) | 1991-03-07 |
AU6276590A (en) | 1991-04-03 |
JPH05501351A (ja) | 1993-03-18 |
US5677182A (en) | 1997-10-14 |
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