ATE402192T1 - Anti-ccr4 antikörper und fragmente davon - Google Patents

Anti-ccr4 antikörper und fragmente davon

Info

Publication number
ATE402192T1
ATE402192T1 AT01908280T AT01908280T ATE402192T1 AT E402192 T1 ATE402192 T1 AT E402192T1 AT 01908280 T AT01908280 T AT 01908280T AT 01908280 T AT01908280 T AT 01908280T AT E402192 T1 ATE402192 T1 AT E402192T1
Authority
AT
Austria
Prior art keywords
ccr4
antibody fragment
antibody
recombinant antibody
cell
Prior art date
Application number
AT01908280T
Other languages
English (en)
Inventor
Kenya Shitara
Nobuo Hanai
Emi Hosaka
Mikiko Sakurada
Akiko Furuya
Kazuyasu Nakamura
Rinpei Niwa
Kenji Shibata
Motoo Yamasaki
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE402192T1 publication Critical patent/ATE402192T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT01908280T 2000-03-03 2001-03-02 Anti-ccr4 antikörper und fragmente davon ATE402192T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000059508 2000-03-03
JP2000401563 2000-12-28

Publications (1)

Publication Number Publication Date
ATE402192T1 true ATE402192T1 (de) 2008-08-15

Family

ID=26586785

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01908280T ATE402192T1 (de) 2000-03-03 2001-03-02 Anti-ccr4 antikörper und fragmente davon

Country Status (15)

Country Link
US (4) US6989145B2 (de)
EP (2) EP1270595B1 (de)
JP (1) JP3926153B2 (de)
KR (1) KR100890873B1 (de)
CN (1) CN100455599C (de)
AT (1) ATE402192T1 (de)
AU (2) AU3607301A (de)
CA (1) CA2401491C (de)
CY (1) CY1108397T1 (de)
DE (1) DE60134962D1 (de)
DK (1) DK1270595T3 (de)
ES (1) ES2309050T3 (de)
PT (1) PT1270595E (de)
SI (1) SI1270595T1 (de)
WO (1) WO2001064754A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
ES2571230T3 (es) * 1999-04-09 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
EP3263702A1 (de) 2000-10-06 2018-01-03 Kyowa Hakko Kirin Co., Ltd. Zellen, die antikörperzusammensetzungen herstellen
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CA2438375C (en) * 2001-03-06 2014-07-15 Kazuhito Fujiyama Plant cell having animal-type sugar chain adding function
US7582299B2 (en) * 2001-04-26 2009-09-01 Biogen Idec Ma Inc. Cripto-specific antibodies
PL207087B1 (pl) * 2001-04-26 2010-10-29 Biogen Przeciwciało, które wiąże się swoiście z białkiem Cripto, zawierająca je kompozycja farmaceutyczna i zastosowanie przeciwciała
US7504104B2 (en) 2001-08-31 2009-03-17 Kyowa Hakko Kogyo Co., Ltd. Human CDR-grafted antibody and antibody fragment thereof
AU2002258011B2 (en) 2001-12-04 2009-01-08 The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Chimeric molecule for the treatment of TH2-like cytokine mediated disorders
US20050095242A1 (en) * 2002-02-28 2005-05-05 Ryuzo Ueda Diagnostics and remedies for interstitial pneumonia
CA2481920A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Antibody composition-containing medicament
WO2004072646A1 (en) * 2003-02-13 2004-08-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 5 (gpr5)
US20050163782A1 (en) * 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
ES2562912T5 (es) 2003-10-01 2020-02-18 Kyowa Hakko Kirin Co Ltd Procedimiento de estabilización de un anticuerpo y preparación de anticuerpo de tipo disolución estabilizada
US20050287138A1 (en) * 2003-10-08 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. CCR4-specific antibody composition
FR2861395B1 (fr) 2003-10-23 2006-02-17 Lab Francais Du Fractionnement Facteur viii viralement securise a faible teneur en multimeres superieurs
WO2005053742A1 (ja) * 2003-12-04 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. 抗体組成物を含有する医薬
US8491902B2 (en) 2003-12-04 2013-07-23 Kyowa Hakko Kirin Co., Ltd. Medicament comprising recombinant antibody against chemokine receptor CCR4
ATE552850T1 (de) 2003-12-23 2012-04-15 Genentech Inc Neue anti-il 13-antikörper und verwendungen dafür
US20060034841A1 (en) * 2004-06-07 2006-02-16 Kyowa Hakko Kogyo Co., Ltd. Method of depleting regulatory T cell
EA200701448A1 (ru) 2005-01-05 2008-02-28 Байоджен Айдек Эмэй Инк. Специфически связывающаяся с крипто-антигеном человека молекула (варианты), композиция на ее основе (варианты), способ получения молекулы, способ лечения посредством молекулы (варианты) и способ ингибирования крипто-экспрессии в клетке больного
WO2009001840A1 (ja) * 2007-06-25 2008-12-31 Forerunner Pharma Research Co., Ltd. ADCC活性又はCDC活性を有する抗Prominin-1抗体
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
JP5552630B2 (ja) * 2008-10-24 2014-07-16 学校法人 聖マリアンナ医科大学 Htlv−i関連脊髄症を治療または予防するための医薬、およびhtlv−i関連脊髄症の患者に対する抗体療法の効果を試験する方法
GB0909906D0 (en) 2009-06-09 2009-07-22 Affitech As Antibodies
CA2775350A1 (en) * 2009-09-24 2011-03-31 Seattle Genetics, Inc. Dr5 ligand drug conjugates
AU2011222012C1 (en) 2010-03-02 2015-02-26 Kyowa Kirin Co., Ltd. Modified antibody composition
US10266599B2 (en) 2010-12-07 2019-04-23 Cancer Research Technology Limited Antibodies which bind to the human CC chemokine receptor 4 and uses thereof
GB201020738D0 (en) 2010-12-07 2011-01-19 Affitech Res As Antibodies
KR101615420B1 (ko) 2010-12-16 2016-04-26 제넨테크, 인크. Th2 억제에 관한 진단 및 치료
US8969526B2 (en) 2011-03-29 2015-03-03 Roche Glycart Ag Antibody Fc variants
EP2723380B1 (de) 2011-06-24 2019-08-21 Stephen D. Gillies Leichtkettige immunglobulin- fusionsproteine und verfahren zu ihrer anwendung
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
US20130280282A1 (en) * 2012-04-24 2013-10-24 Daiichi Sankyo Co., Ltd. Dr5 ligand drug conjugates
WO2014007303A1 (ja) 2012-07-06 2014-01-09 学校法人 聖マリアンナ医科大学 Htlv-1関連脊髄症患者の治療方法および治療剤
WO2014009465A1 (en) 2012-07-13 2014-01-16 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
WO2015038884A2 (en) 2013-09-13 2015-03-19 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
CA2921999C (en) 2013-09-13 2023-03-21 Genentech, Inc. Methods and compositions comprising an anti-il13 antibody and residual hamster phospholipase b-like 2
CN114634571A (zh) * 2014-10-06 2022-06-17 达纳-法伯癌症研究所公司 人源化cc趋化因子受体4 (ccr4)抗体及其使用方法
US20180271861A1 (en) 2015-07-14 2018-09-27 Kyowa Hakko Kirin Co., Ltd. Therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody
WO2017112564A1 (en) 2015-12-22 2017-06-29 3M Innovative Properties Company Stem-well films for sample partitioning
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
WO2018106699A1 (en) * 2016-12-08 2018-06-14 Nantbio, Inc. Method of validating the triggering of an immune response to a neoepitope of a tumor with t-cells
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
EP3765500A2 (de) 2018-03-16 2021-01-20 Zoetis Services LLC Monoklonale interleukin-31-antikörper zur verwendung in der veterinärmedizin
AU2019236328A1 (en) 2018-03-16 2020-09-10 Zoetis Services Llc Peptide vaccines against Interleukin-31
JP2021519589A (ja) * 2018-03-29 2021-08-12 アールイーエムディー バイオセラピューティクス,インコーポレイテッドREMD Biotherapeutics,Inc インターロイキン17a(il−17a)に結合する抗体を用いた自己免疫障害及び炎症障害の治療
US11279698B2 (en) 2018-11-20 2022-03-22 Cornell University Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US160015A (en) * 1875-02-23 Improvement in devices for cutting out sheet-metal washers
US187930A (en) * 1877-02-27 Improvement in processes of preserving meat
US19341A (en) * 1858-02-16 Louis beauche
CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
JPH02257891A (ja) 1989-03-31 1990-10-18 Kyowa Hakko Kogyo Co Ltd 組換え動物細胞による蛋白質の製造
US5914110A (en) 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
JPH0853355A (ja) 1994-08-12 1996-02-27 Taisho Pharmaceut Co Ltd Il−5産生抑制剤
GB9501683D0 (en) 1995-01-27 1995-03-15 Glaxo Group Ltd Substances and their uses
US6498015B1 (en) * 1995-06-07 2002-12-24 Icos Corporation Methods of identifying agents that modulate the binding between MDC and an MDC receptor
HUP9701282A3 (en) * 1995-06-07 1999-09-28 Icos Corp Bothell Macrophage derived chemokine and chemokine analogs
CA2205007C (en) 1995-09-11 2010-12-14 Masamichi Koike Antibody against human interleukin-5 receptor .alpha. chain
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
KR100440836B1 (ko) 1997-11-12 2004-07-19 에프. 호프만-라 로슈 아게 레티노이드 길항제를 이용한 제2형 t-보조세포 중재 면역질환의 치료
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
TR200003768T2 (tr) 1998-06-26 2001-06-21 Chugai Seiyaku Kabushiki Kaisha Hiperkalsemik krizler için terapötik aktif madde.
US6488930B1 (en) 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
US6245332B1 (en) 1999-01-15 2001-06-12 The Board Of Trustees Of The Leland Stanford Junior University Modulation of systemic memory T cell trafficking
EP1050307A1 (de) * 1999-05-06 2000-11-08 Applied Research Systems ARS Holding N.V. CCR4 Antagoniste in Sepsis
US7504104B2 (en) 2001-08-31 2009-03-17 Kyowa Hakko Kogyo Co., Ltd. Human CDR-grafted antibody and antibody fragment thereof
US20050287138A1 (en) * 2003-10-08 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. CCR4-specific antibody composition
US8491902B2 (en) * 2003-12-04 2013-07-23 Kyowa Hakko Kirin Co., Ltd. Medicament comprising recombinant antibody against chemokine receptor CCR4
US20060034841A1 (en) * 2004-06-07 2006-02-16 Kyowa Hakko Kogyo Co., Ltd. Method of depleting regulatory T cell

Also Published As

Publication number Publication date
CA2401491C (en) 2011-07-05
DK1270595T3 (da) 2008-11-10
ES2309050T3 (es) 2008-12-16
CN100455599C (zh) 2009-01-28
US20120276090A1 (en) 2012-11-01
US6989145B2 (en) 2006-01-24
AU2001236073B2 (en) 2006-10-19
KR100890873B1 (ko) 2009-03-31
EP1270595A4 (de) 2005-07-27
JP3926153B2 (ja) 2007-06-06
US8197814B2 (en) 2012-06-12
KR20020089377A (ko) 2002-11-29
CN1407993A (zh) 2003-04-02
CA2401491A1 (en) 2001-09-07
US20050187380A1 (en) 2005-08-25
SI1270595T1 (sl) 2008-12-31
US7666418B2 (en) 2010-02-23
US8632996B2 (en) 2014-01-21
US20100221178A1 (en) 2010-09-02
US20020098527A1 (en) 2002-07-25
CY1108397T1 (el) 2014-02-12
EP1992644A1 (de) 2008-11-19
WO2001064754A1 (fr) 2001-09-07
DE60134962D1 (de) 2008-09-04
PT1270595E (pt) 2008-09-16
AU3607301A (en) 2001-09-12
EP1270595B1 (de) 2008-07-23
EP1270595A1 (de) 2003-01-02

Similar Documents

Publication Publication Date Title
DE60134962D1 (de) Anti-ccr4 antikörper und fragmente davon
EA200500497A3 (ru) ЧЕЛОВЕЧЕСКИЕ АНТИ-IFN-γ НЕЙТРАЛИЗУЮЩИЕ АНТИТЕЛА В КАЧЕСТВЕ СЕЛЕКТИВНЫХ ИНГИБИТОРОВ ПУТЕЙ IFN-γ
TR200002731T2 (tr) Proteolitik antikorların indüktör ve inhibitörlerinin tanımlanması, kompozisyonları ve kullanımları için metotlar
HUP9802212A2 (hu) Humán terápiában alkalmazható rekombináns anti-CD4-ellenanyagok
MXPA03000103A (es) Antigenos de streptococcus.
PH12012501089A1 (en) Therapeutic human anti-il-1r1 monoclonal antibody
WO2005120166A3 (en) Antibodies for selective apoptosis of cells
HK1087018A1 (en) Peptide-based passive immunization therapy for treatment of atherosclerosis
ATE407147T1 (de) Fab-fragmente humaner monoklonaler antikörper mit neutralisierender aktivität gegen das hcv e2 glycoprotein
IL144265A0 (en) Use of antibodies for the vaccination against cancer
IT1307864B1 (it) Metodo diagnostico per il riconoscimento di neoplasie umane attraversola determinazione dell'isoforma ctn-c della tn-c, frammenti di
WO2004030607A3 (en) Peptide-based passive immunization therapy for treatment of atherosclerosis
ATE537257T1 (de) Mit iga-nephropathie assoziierte dns
SE0202959D0 (sv) Peptide-Base passive immunization therapy for treatment of atherosclerosis
WO2001079434A3 (fr) Nouveau polypeptide, signal peptidase humaine 10, et polynucleotide codant pour ce polypeptide
WO2001075010A3 (fr) Nouveau polypeptide, proteine humaine de transduction nucleaire 25 contenant un domaine structurel atp/gtp, et polynucleotide codant pour ce polypeptide
WO2001079431A3 (fr) Nouveau polypeptide, proteine humaine d'interaction 15 avec la proteine huntingtine, et polynucleotide codant pour ce polypeptide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1270595

Country of ref document: EP

EEFA Change of the company name