IT1264083B1 - Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. - Google Patents
Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.Info
- Publication number
- IT1264083B1 IT1264083B1 IT93RM000818A ITRM930818A IT1264083B1 IT 1264083 B1 IT1264083 B1 IT 1264083B1 IT 93RM000818 A IT93RM000818 A IT 93RM000818A IT RM930818 A ITRM930818 A IT RM930818A IT 1264083 B1 IT1264083 B1 IT 1264083B1
- Authority
- IT
- Italy
- Prior art keywords
- antibody
- plants
- production
- diagnosis
- therapy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108700020796 Oncogene Proteins 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
Abstract
E' descritto un procedimento per la produzione di anticorpi ad uso diagnostico e terapeutico in piante. Preferibilmente gli anticorpi dell'invenzione riconoscono l'oncogene HERZ presente in tumori della mammella e ovaie.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93RM000818A IT1264083B1 (it) | 1993-12-10 | 1993-12-10 | Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. |
EP94830567A EP0657538A3 (en) | 1993-12-10 | 1994-12-07 | Process for the production of genetically engineered antibodies in plants, genetically engineered antibodies and their use in diagnosis and therapy. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93RM000818A IT1264083B1 (it) | 1993-12-10 | 1993-12-10 | Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM930818A0 ITRM930818A0 (it) | 1993-12-10 |
ITRM930818A1 ITRM930818A1 (it) | 1995-06-10 |
IT1264083B1 true IT1264083B1 (it) | 1996-09-10 |
Family
ID=11402090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93RM000818A IT1264083B1 (it) | 1993-12-10 | 1993-12-10 | Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0657538A3 (it) |
IT (1) | IT1264083B1 (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
JP2000504567A (ja) * | 1996-02-08 | 2000-04-18 | インスティテュート フュール ファランツェンジェネティック ウント カルテュルファランツェンフォルシュンク | 植物での貯蔵安定性蛋白質の発現のためのカセット |
US5990385A (en) * | 1997-11-10 | 1999-11-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Protein production in transgenic alfalfa plants |
US20030049262A1 (en) * | 1998-10-02 | 2003-03-13 | Susan Love | Methods for identification, diagnosis, and treatment of breast cancer |
EP1118669A3 (en) * | 1999-12-17 | 2001-08-29 | Unilever Plc | Production of camelid antibodies in plants |
CN102686730A (zh) * | 2009-11-16 | 2012-09-19 | 亚赛特生物技术私人有限公司 | 重组抗体载体 |
WO2015113055A2 (en) * | 2014-01-27 | 2015-07-30 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Plant-derived antibodies and derivatives that reduce risk of antibody-dependent enhancement (ade) of infection |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69033842T2 (de) * | 1989-08-04 | 2002-06-20 | Schering Ag | Äusserliche domäne von c-erbb-2:gp75 |
US5202422A (en) * | 1989-10-27 | 1993-04-13 | The Scripps Research Institute | Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use |
AU662311B2 (en) * | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
IT1248361B (it) * | 1991-06-28 | 1995-01-05 | Enea | Vettori plasmidici per l'espressione di geni in piante |
EP1997894B1 (en) * | 1992-02-06 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
-
1993
- 1993-12-10 IT IT93RM000818A patent/IT1264083B1/it active IP Right Grant
-
1994
- 1994-12-07 EP EP94830567A patent/EP0657538A3/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ITRM930818A1 (it) | 1995-06-10 |
EP0657538A3 (en) | 1996-03-06 |
ITRM930818A0 (it) | 1993-12-10 |
EP0657538A2 (en) | 1995-06-14 |
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Legal Events
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0001 | Granted |