ATE186540T1 - Wasserlösliche azol-antifungus - Google Patents

Wasserlösliche azol-antifungus

Info

Publication number
ATE186540T1
ATE186540T1 AT95906968T AT95906968T ATE186540T1 AT E186540 T1 ATE186540 T1 AT E186540T1 AT 95906968 T AT95906968 T AT 95906968T AT 95906968 T AT95906968 T AT 95906968T AT E186540 T1 ATE186540 T1 AT E186540T1
Authority
AT
Austria
Prior art keywords
hydrogen
6alkyl
pct
image
antifungus
Prior art date
Application number
AT95906968T
Other languages
English (en)
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Der Eycken Luc Alfons Leo Van
Frank Christopher Odds
Jean Louis Mesens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE186540T1 publication Critical patent/ATE186540T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • External Artificial Organs (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT95906968T 1994-01-24 1995-01-17 Wasserlösliche azol-antifungus ATE186540T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18535294A 1994-01-24 1994-01-24

Publications (1)

Publication Number Publication Date
ATE186540T1 true ATE186540T1 (de) 1999-11-15

Family

ID=22680644

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906968T ATE186540T1 (de) 1994-01-24 1995-01-17 Wasserlösliche azol-antifungus

Country Status (31)

Country Link
US (1) US5707977A (de)
EP (1) EP0741737B1 (de)
JP (1) JP3764750B2 (de)
KR (1) KR100352147B1 (de)
CN (1) CN1078210C (de)
AT (1) ATE186540T1 (de)
AU (1) AU688455B2 (de)
CA (1) CA2179640C (de)
CY (1) CY2176B1 (de)
CZ (1) CZ288544B6 (de)
DE (1) DE69513279T2 (de)
DK (1) DK0741737T3 (de)
ES (1) ES2141329T3 (de)
FI (1) FI116057B (de)
GR (1) GR3032550T3 (de)
HU (1) HU227281B1 (de)
IL (1) IL112413A (de)
LV (1) LV12634B (de)
MY (1) MY111814A (de)
NO (1) NO308412B1 (de)
NZ (1) NZ278882A (de)
PH (1) PH31664A (de)
PL (1) PL181947B1 (de)
PT (1) PT741737E (de)
RU (1) RU2156764C2 (de)
SG (1) SG48386A1 (de)
SI (1) SI0741737T1 (de)
SK (1) SK282059B6 (de)
TW (1) TW376385B (de)
WO (1) WO1995019983A1 (de)
ZA (1) ZA95521B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW457240B (en) 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
AR002751A1 (es) * 1995-06-02 1998-04-29 Schering Corp Antifungicos de tetrahidrofurano, composiciones farmaceuticas que los contienen y el uso de los compuestos para preparar composiciones farmaceuticas utiles para el tratamiento de infecciones fungicas
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
AU5251298A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. (2r,4s,s,r-) and (2s,4r,s,r-)hydroxyitraconazole
WO1998021205A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole
JP2001504465A (ja) * 1996-11-12 2001-04-03 セプラコール，インク． ２ｒ，４ｓ，ｓ，ｓ―および２ｓ，４ｒ，ｓ，ｓ―ヒドロキシイトラコナゾール
CA2269617A1 (en) * 1996-11-12 1998-05-22 Chris H. Senanayake 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
JP4347911B2 (ja) * 1997-02-11 2009-10-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノ酸エステル含有アゾール抗真菌剤
TW593312B (en) * 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
UA63954C2 (en) * 1997-07-11 2004-02-16 Janssen Pharmaceutica Nv (+/-) norcisapride, a process for the preparation thereof, intermediate compounds, composition based thereon for use in the manufacture of medicaments for treating gastro-intestinal disorders
ZA989063B (en) * 1997-10-07 1999-04-06 Schering Corp Crystalline antifungal polymorph
EP0957101A1 (de) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus
US6265584B1 (en) * 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
WO2000030655A1 (en) 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2343980A4 (de) * 2008-09-08 2012-06-06 Nian Wu Triazolfungizide
RU2563811C1 (ru) * 2014-08-08 2015-09-20 Федеральное государственное бюджетное учреждение науки Институт химической физики им. Н.Н. Семенова Российской академии наук (ИХФ РАН) Фармацевтическая композиция для лечения грибковых заболеваний
CN106243087B (zh) * 2016-09-12 2018-10-09 三峡大学 一种***吡咯烷酮类杀菌剂，合成方法及其应用
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
CZ294823B6 (cs) * 1993-12-21 2005-03-16 Schering Corporation Fungicidní tetrahydrofurany

Also Published As

Publication number Publication date
HU227281B1 (en) 2011-01-28
FI116057B (fi) 2005-09-15
FI962947A (fi) 1996-07-23
CZ288544B6 (cs) 2001-07-11
IL112413A (en) 1999-11-30
NZ278882A (en) 1997-06-24
CA2179640C (en) 2005-11-15
WO1995019983A1 (en) 1995-07-27
JPH09508360A (ja) 1997-08-26
NO963073D0 (no) 1996-07-23
CN1138862A (zh) 1996-12-25
JP3764750B2 (ja) 2006-04-12
LV12634B (en) 2001-07-20
EP0741737A1 (de) 1996-11-13
DE69513279D1 (de) 1999-12-16
EP0741737B1 (de) 1999-11-10
HUT75943A (en) 1997-05-28
PH31664A (en) 1999-01-12
DE69513279T2 (de) 2000-07-13
MY111814A (en) 2001-01-31
SK89696A3 (en) 1998-02-04
TW376385B (en) 1999-12-11
CN1078210C (zh) 2002-01-23
PL315558A1 (en) 1996-11-12
HU9602008D0 (en) 1996-09-30
SK282059B6 (sk) 2001-10-08
SI0741737T1 (en) 2000-02-29
CY2176B1 (en) 2002-08-23
ZA95521B (en) 1996-07-23
RU2156764C2 (ru) 2000-09-27
GR3032550T3 (en) 2000-05-31
LV12634A (lv) 2001-03-20
PT741737E (pt) 2000-04-28
AU1535595A (en) 1995-08-08
US5707977A (en) 1998-01-13
IL112413A0 (en) 1995-03-30
NO963073L (no) 1996-07-23
DK0741737T3 (da) 2000-05-22
NO308412B1 (no) 2000-09-11
SG48386A1 (en) 1998-04-17
PL181947B1 (en) 2001-10-31
AU688455B2 (en) 1998-03-12
FI962947A0 (fi) 1996-07-23
KR100352147B1 (ko) 2002-11-11
CA2179640A1 (en) 1995-07-27
CZ195696A3 (en) 1997-02-12
ES2141329T3 (es) 2000-03-16

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Legal Events

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UEP Publication of translation of european patent specification