ATE185606T1 - Monoklonale antikörper gegen putative hcv-e2/ns1- proteine und verfahren zu ihrer verwendung - Google Patents

Monoklonale antikörper gegen putative hcv-e2/ns1- proteine und verfahren zu ihrer verwendung

Info

Publication number
ATE185606T1
ATE185606T1 AT92920089T AT92920089T ATE185606T1 AT E185606 T1 ATE185606 T1 AT E185606T1 AT 92920089 T AT92920089 T AT 92920089T AT 92920089 T AT92920089 T AT 92920089T AT E185606 T1 ATE185606 T1 AT E185606T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
methods
proteins
antibodies against
putative hcv
Prior art date
Application number
AT92920089T
Other languages
English (en)
Inventor
Smriti U Mehta
Jill E Johnson
Stephen H Dailey
Suresh M Desai
Sushil G Devare
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE185606T1 publication Critical patent/ATE185606T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/82—Hepatitis associated antigens and antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92920089T 1991-08-21 1992-08-21 Monoklonale antikörper gegen putative hcv-e2/ns1- proteine und verfahren zu ihrer verwendung ATE185606T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/748,292 US5308750A (en) 1989-12-22 1991-08-21 Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same

Publications (1)

Publication Number Publication Date
ATE185606T1 true ATE185606T1 (de) 1999-10-15

Family

ID=25008836

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92920089T ATE185606T1 (de) 1991-08-21 1992-08-21 Monoklonale antikörper gegen putative hcv-e2/ns1- proteine und verfahren zu ihrer verwendung

Country Status (9)

Country Link
US (1) US5308750A (de)
EP (1) EP0603307B1 (de)
JP (1) JP3335351B2 (de)
AT (1) ATE185606T1 (de)
AU (1) AU2585092A (de)
CA (1) CA2115923A1 (de)
DE (1) DE69230146T2 (de)
ES (1) ES2139607T3 (de)
WO (1) WO1993004205A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273115B1 (de) * 1986-10-22 1994-09-07 Abbott Laboratories Chemilumineszierende Acridinium- und Phenantridiniumsalze
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US6312889B1 (en) 1990-04-04 2001-11-06 Chiron Corporation Combinations of hepatitis c virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
CA2129733C (en) * 1992-01-31 2006-10-31 James M. Casey Mammalian expression systems for hcv proteins
CA2162557C (en) 1993-05-12 2004-09-28 Amy J. Weiner Conserved motif of hepatitis c virus e2/ns1 region
US5824507A (en) * 1994-05-20 1998-10-20 Genelabs Technologies, Inc. Hepatitis G virus and molecular cloning thereof
JP3217600B2 (ja) * 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
EP1211315A1 (de) * 1994-07-29 2002-06-05 Innogenetics N.V. Rekombinante Vektoren zur Herstellung von HCV Hüllproteinen
US20040185061A1 (en) * 1994-07-29 2004-09-23 Innogenetics N.V. Redox reversible HCV proteins with native-like conformation
CN1044384C (zh) * 1994-08-25 1999-07-28 中国药品生物制品检定所 抗丙型肝炎病毒抗原单克隆抗体细胞株建立及其单克隆抗体
GB9517926D0 (en) 1995-09-01 1995-11-01 Biocine Spa Binding protein
US6747136B2 (en) * 1996-04-19 2004-06-08 Karolinska Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
US6538114B1 (en) 1996-04-19 2003-03-25 Karolina Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
JPH10136990A (ja) * 1996-09-18 1998-05-26 Boehringer Mannheim Gmbh Ｇ型肝炎ウイルスに対する抗体、ｈｇｖの診断検出のた めのおよび治療薬としてのその使用
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
EP0947525A1 (de) 1998-03-27 1999-10-06 Innogenetics N.V. Epitope in der viralen Hüllproteine und spezifische Antikörper gegen diese Epitope: Verwendung für die detektion von viralantigene im empfängergewebe
US7108855B2 (en) * 1998-06-24 2006-09-19 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
US7091324B2 (en) * 1998-11-05 2006-08-15 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
CA2380777C (en) * 1999-07-28 2011-01-04 Chiron Corporation Hepatitis c viral antigen immunoassay detection systems
US6815160B1 (en) 1999-07-28 2004-11-09 Chiron Corporation Hepatitis C viral antigen immunoassay detection systems
WO2002036833A1 (en) * 2000-11-06 2002-05-10 Bio-Tech Imaging, Inc. Method and kits for detecting hepatitis infected cells
AU2002243259B2 (en) * 2000-12-01 2008-02-07 The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Monoclonal antibodies specific for the E2 glycoprotein of hepatitis C virus and their use in the diagnosis, treatment, and prevention of hepatitis C
US7101561B2 (en) 2000-12-01 2006-09-05 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
GB0112652D0 (en) * 2001-05-24 2001-07-18 Inst Of Molecul & Cell Biology Internalisation of virus into cells
US7858752B2 (en) * 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
NZ579706A (en) 2007-02-21 2012-03-30 Univ Massachusetts Human antibodues against hepatitis C virus (HCV) E2 protein and uses thereof
US20080227111A1 (en) * 2007-03-16 2008-09-18 Sysmex Corporation Reagent kit and method for measuring hcv antibody
EP2201023A2 (de) * 2007-09-14 2010-06-30 GENimmune N.V. Affinitäts-tag
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227011A (en) * 1987-11-18 1992-03-26 Chiron Corp Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits
HUT54896A (en) * 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
AU638304B2 (en) * 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
EP0464287A1 (de) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide
CA2047792C (en) * 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens

Also Published As

Publication number Publication date
EP0603307A1 (de) 1994-06-29
EP0603307B1 (de) 1999-10-13
CA2115923A1 (en) 1993-03-04
JPH06510192A (ja) 1994-11-17
JP3335351B2 (ja) 2002-10-15
DE69230146T2 (de) 2000-05-25
AU2585092A (en) 1993-03-16
ES2139607T3 (es) 2000-02-16
DE69230146D1 (de) 1999-11-18
US5308750A (en) 1994-05-03
EP0603307A4 (de) 1995-01-18
WO1993004205A1 (en) 1993-03-04

Similar Documents

Publication Publication Date Title
ATE185606T1 (de) Monoklonale antikörper gegen putative hcv-e2/ns1- proteine und verfahren zu ihrer verwendung
DK0765478T3 (da) Positiv og positiv/negativ celleselektion medieret af peptidfrigørelse
ATE171472T1 (de) Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4
FI20021626A (fi) Immuunimäärityksen reagenssi ja menetelmä hepatiitti C-viruksen (HCV) vasta-aineiden havaitsemiseksi
ATE239756T1 (de) Humaner monoklonaler antikörper gegen hepatitis b virus oberflächen antigen (hbvsag)
FI942369A (fi) Hepatitis-C-virustesti
DE69932812D1 (de) Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe
NO20051715L (no) HCV assay
DK1200126T3 (da) Anvendelse af CD28-specifikke monoklonale antistoffer til fremstilling af en farmaceutisk sammensætning til behandling af virusinfektioner
ATE167522T1 (de) Monoklonale antikörper gegen mögliche hcv- hüllregionen und methoden diese zu benutzen
DE69224134D1 (de) Monoklonale Antikörper gegen Hepatitis-C-Virus
ATE202117T1 (de) Angiotensin ii rezeptor typ i spezifische monoklonale antikörper und hybridoma
DE69227776D1 (de) Monoklonale antikörper gegen mutmassliche hepatitis c-virus ns5-proteine und ihre anwendungsmethoden
ATE178096T1 (de) Monoklonale antikörper gegen den hepatitis c- virus und verfahren diese zu benutzen
ATE294237T1 (de) S?ugetier thymokingene
Suzuki et al. Idiotypic and fine specificity analysis of a (4‐hydroxy‐3‐nitrophenyl) acetyl (NP)‐specific suppressor T cell hybridoma at the level of cell surface structures, isolated receptor material and functional suppressor factor
KR950700423A (ko) 씨(c)형 간염 비루스에 대한 단일클론 항체 및 항-유전자형 항체(monoclonal antibodies and anti-idiotypic antibodies to hepatitis c virus)
DE60029570D1 (de) Verfahren zur isolierung der cd8+-zellen, und entsprechende hybridomazellen, antikörper und polypeptide
KR900700135A (ko) 광견병 비루스 세포를 특이적으로 인지하는 사람 모노클로날 항체, 이의 생성세포, 그 항체를 함유하는 제제 및 이들의 제조방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee