ATE182336T1 - Peptidinhibitoren der urokinaserezeptor-aktivität - Google Patents
Peptidinhibitoren der urokinaserezeptor-aktivitätInfo
- Publication number
- ATE182336T1 ATE182336T1 AT94918058T AT94918058T ATE182336T1 AT E182336 T1 ATE182336 T1 AT E182336T1 AT 94918058 T AT94918058 T AT 94918058T AT 94918058 T AT94918058 T AT 94918058T AT E182336 T1 ATE182336 T1 AT E182336T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor activity
- peptide inhibitors
- urokinase receptor
- urokinase
- active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6151493A | 1993-05-28 | 1993-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE182336T1 true ATE182336T1 (de) | 1999-08-15 |
Family
ID=22036265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94918058T ATE182336T1 (de) | 1993-05-28 | 1994-05-19 | Peptidinhibitoren der urokinaserezeptor-aktivität |
Country Status (12)
Country | Link |
---|---|
US (2) | US5656726A (de) |
EP (1) | EP0745092B1 (de) |
JP (2) | JPH08510742A (de) |
KR (1) | KR960702846A (de) |
AT (1) | ATE182336T1 (de) |
AU (1) | AU682877B2 (de) |
CA (1) | CA2163741A1 (de) |
DE (1) | DE69419623T2 (de) |
FI (1) | FI955720A0 (de) |
NO (1) | NO954722D0 (de) |
NZ (1) | NZ267291A (de) |
WO (1) | WO1994028014A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5519120A (en) * | 1989-04-07 | 1996-05-21 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor antibodies |
EP0802983B1 (de) | 1993-06-01 | 2003-05-02 | Chiron Corporation | Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp |
US6248715B1 (en) | 1993-06-01 | 2001-06-19 | Chiron Corporation | Method of treating a urokinase-type plasminogen activator-mediated disorder |
US6030940A (en) * | 1995-07-31 | 2000-02-29 | Chiron Corporation | Peptide analog inhibitors of urokinase receptor activity |
EP0842281A1 (de) * | 1995-07-31 | 1998-05-20 | Chiron Corporation | Peptidanaloge inhibitoren der aktivität des urokinase-rezeptors |
US6010699A (en) * | 1996-03-15 | 2000-01-04 | Senju Pharmaceutical Co., Ltd. | Method for controlling axial length of the eye |
US20040204348A1 (en) * | 1996-11-12 | 2004-10-14 | The Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
US6277818B1 (en) * | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
US5942492A (en) * | 1996-11-12 | 1999-08-24 | Angstrom Pharmaceuticals, Inc. | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
US6462170B1 (en) * | 1997-03-20 | 2002-10-08 | Fondazione Centro San Raffaele Del Monte Tabor | UPAR mimicking peptide |
US6794358B1 (en) * | 1997-03-28 | 2004-09-21 | Brigham And Women's Hospital | Peptide ligands of the urokinase receptor |
US5994309A (en) | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
CA2346053A1 (en) | 1998-10-02 | 2000-04-13 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor |
GB0002366D0 (en) * | 2000-02-03 | 2000-03-22 | Astrazeneca Uk Ltd | Diagnostic method |
US7566765B2 (en) * | 2000-03-06 | 2009-07-28 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds containing a nine-membered carbon-nitrogen ring |
ATE478688T1 (de) * | 2000-06-20 | 2010-09-15 | Dainippon Sumitomo Pharma Co | Verbindungen für den transfer von oligonukleotiden |
US6649597B1 (en) * | 2000-06-22 | 2003-11-18 | The University Of Iowa Research Foundation | Targeting vector to the urokinase plasminogen activator receptor |
DE60232149D1 (de) * | 2001-06-20 | 2009-06-10 | Dainippon Sumitomo Pharma Co | Verfahren zur förderung des nukleinsäuretransfers |
US6908899B2 (en) * | 2001-08-17 | 2005-06-21 | U.S. Dept. Of Veterans Affairs | Pro-inflammatory fibrinopeptide |
WO2003045977A2 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes |
WO2003051347A1 (en) * | 2001-12-19 | 2003-06-26 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Use of urokinase receptor antagonists to modulate ischemiareperfusion injury |
WO2005061717A1 (ja) * | 2003-12-19 | 2005-07-07 | Dainippon Sumitomo Pharma Co., Ltd. | 新規な核酸導入法 |
US20090062184A1 (en) * | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
TW200813091A (en) * | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
US10787670B2 (en) | 2016-09-15 | 2020-09-29 | Labcyte Inc. | High-efficiency transfection of biological cells using sonoporation |
CA3078630A1 (en) | 2017-10-12 | 2019-04-18 | Sutrovax, Inc. | Periodontitis vaccine and related compositions and method of use |
JP7307062B2 (ja) | 2017-11-22 | 2023-07-11 | ラブサイト インコーポレイテッド | 連続流動サンプリングプローブを使用する分析器具の音響装填のためのシステムおよび方法 |
CN112236519A (zh) | 2018-03-03 | 2021-01-15 | 拉伯塞特股份有限公司 | 使用声学液滴喷射从样品中提取目标部分的***和方法 |
WO2020205584A1 (en) | 2019-04-02 | 2020-10-08 | Vaxcyte, Inc. | Optimized cell-free synthesis of invasion plasmid antigen b and related compositions and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4631270A (en) * | 1978-11-20 | 1986-12-23 | Research Corporation | Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use |
US5519120A (en) * | 1989-04-07 | 1996-05-21 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor antibodies |
DK182289D0 (da) * | 1989-04-14 | 1989-04-14 | Francesco Blasi | Modifikation af proteiner |
US5039791A (en) * | 1989-11-06 | 1991-08-13 | Monsanto Company | Peptide fragments of tissue plasminogen activator |
GB2246779B (en) * | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
WO1993009808A1 (en) * | 1991-11-18 | 1993-05-27 | The Regents Of The University Of Michigan | METHODS FOR DETECTING AND ISOLATING uPA-R AND INHIBITING THE BINDING OF uPA TO uPA-R |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
-
1994
- 1994-05-19 KR KR1019950705327A patent/KR960702846A/ko not_active Application Discontinuation
- 1994-05-19 DE DE69419623T patent/DE69419623T2/de not_active Expired - Fee Related
- 1994-05-19 AT AT94918058T patent/ATE182336T1/de not_active IP Right Cessation
- 1994-05-19 WO PCT/US1994/005684 patent/WO1994028014A2/en active IP Right Grant
- 1994-05-19 NZ NZ267291A patent/NZ267291A/en unknown
- 1994-05-19 CA CA002163741A patent/CA2163741A1/en not_active Abandoned
- 1994-05-19 JP JP7500825A patent/JPH08510742A/ja active Pending
- 1994-05-19 AU AU69542/94A patent/AU682877B2/en not_active Ceased
- 1994-05-19 EP EP94918058A patent/EP0745092B1/de not_active Expired - Lifetime
-
1995
- 1995-01-09 US US08/370,567 patent/US5656726A/en not_active Expired - Lifetime
- 1995-05-10 US US08/438,759 patent/US5679782A/en not_active Expired - Lifetime
- 1995-11-22 NO NO954722A patent/NO954722D0/no unknown
- 1995-11-27 FI FI955720A patent/FI955720A0/fi not_active Application Discontinuation
-
1998
- 1998-11-18 JP JP10328556A patent/JPH11240897A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FI955720A (fi) | 1995-11-27 |
JPH08510742A (ja) | 1996-11-12 |
AU682877B2 (en) | 1997-10-23 |
WO1994028014A2 (en) | 1994-12-08 |
DE69419623D1 (de) | 1999-08-26 |
EP0745092B1 (de) | 1999-07-21 |
NZ267291A (en) | 1997-09-22 |
JPH11240897A (ja) | 1999-09-07 |
NO954722L (no) | 1995-11-22 |
FI955720A0 (fi) | 1995-11-27 |
NO954722D0 (no) | 1995-11-22 |
AU6954294A (en) | 1994-12-20 |
US5679782A (en) | 1997-10-21 |
WO1994028014A3 (en) | 1995-01-26 |
DE69419623T2 (de) | 1999-12-02 |
KR960702846A (ko) | 1996-05-23 |
CA2163741A1 (en) | 1994-12-08 |
US5656726A (en) | 1997-08-12 |
EP0745092A1 (de) | 1996-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |