ATE182336T1 - Peptidinhibitoren der urokinaserezeptor-aktivität - Google Patents

Peptidinhibitoren der urokinaserezeptor-aktivität

Info

Publication number
ATE182336T1
ATE182336T1 AT94918058T AT94918058T ATE182336T1 AT E182336 T1 ATE182336 T1 AT E182336T1 AT 94918058 T AT94918058 T AT 94918058T AT 94918058 T AT94918058 T AT 94918058T AT E182336 T1 ATE182336 T1 AT E182336T1
Authority
AT
Austria
Prior art keywords
receptor activity
peptide inhibitors
urokinase receptor
urokinase
active
Prior art date
Application number
AT94918058T
Other languages
English (en)
Inventor
Steven Rosenberg
Michael V Doyle
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE182336T1 publication Critical patent/ATE182336T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
AT94918058T 1993-05-28 1994-05-19 Peptidinhibitoren der urokinaserezeptor-aktivität ATE182336T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6151493A 1993-05-28 1993-05-28

Publications (1)

Publication Number Publication Date
ATE182336T1 true ATE182336T1 (de) 1999-08-15

Family

ID=22036265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918058T ATE182336T1 (de) 1993-05-28 1994-05-19 Peptidinhibitoren der urokinaserezeptor-aktivität

Country Status (12)

Country Link
US (2) US5656726A (de)
EP (1) EP0745092B1 (de)
JP (2) JPH08510742A (de)
KR (1) KR960702846A (de)
AT (1) ATE182336T1 (de)
AU (1) AU682877B2 (de)
CA (1) CA2163741A1 (de)
DE (1) DE69419623T2 (de)
FI (1) FI955720A0 (de)
NO (1) NO954722D0 (de)
NZ (1) NZ267291A (de)
WO (1) WO1994028014A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
EP0802983B1 (de) 1993-06-01 2003-05-02 Chiron Corporation Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp
US6248715B1 (en) 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
US6030940A (en) * 1995-07-31 2000-02-29 Chiron Corporation Peptide analog inhibitors of urokinase receptor activity
EP0842281A1 (de) * 1995-07-31 1998-05-20 Chiron Corporation Peptidanaloge inhibitoren der aktivität des urokinase-rezeptors
US6010699A (en) * 1996-03-15 2000-01-04 Senju Pharmaceutical Co., Ltd. Method for controlling axial length of the eye
US20040204348A1 (en) * 1996-11-12 2004-10-14 The Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US5942492A (en) * 1996-11-12 1999-08-24 Angstrom Pharmaceuticals, Inc. Cyclic peptides that bind to urokinase-type plasminogen activator receptor
US6462170B1 (en) * 1997-03-20 2002-10-08 Fondazione Centro San Raffaele Del Monte Tabor UPAR mimicking peptide
US6794358B1 (en) * 1997-03-28 2004-09-21 Brigham And Women's Hospital Peptide ligands of the urokinase receptor
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
CA2346053A1 (en) 1998-10-02 2000-04-13 Santen Pharmaceutical Co., Ltd. Angiogenesis inhibitor
GB0002366D0 (en) * 2000-02-03 2000-03-22 Astrazeneca Uk Ltd Diagnostic method
US7566765B2 (en) * 2000-03-06 2009-07-28 Rigel Pharmaceuticals, Inc. Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
ATE478688T1 (de) * 2000-06-20 2010-09-15 Dainippon Sumitomo Pharma Co Verbindungen für den transfer von oligonukleotiden
US6649597B1 (en) * 2000-06-22 2003-11-18 The University Of Iowa Research Foundation Targeting vector to the urokinase plasminogen activator receptor
DE60232149D1 (de) * 2001-06-20 2009-06-10 Dainippon Sumitomo Pharma Co Verfahren zur förderung des nukleinsäuretransfers
US6908899B2 (en) * 2001-08-17 2005-06-21 U.S. Dept. Of Veterans Affairs Pro-inflammatory fibrinopeptide
WO2003045977A2 (en) * 2001-11-26 2003-06-05 Trustees Of Tufts College Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes
WO2003051347A1 (en) * 2001-12-19 2003-06-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of urokinase receptor antagonists to modulate ischemiareperfusion injury
WO2005061717A1 (ja) * 2003-12-19 2005-07-07 Dainippon Sumitomo Pharma Co., Ltd. 新規な核酸導入法
US20090062184A1 (en) * 2005-03-24 2009-03-05 Dainippon Sumitomo Pharma Co., Ltd. Fine particulate preparation comprising complex of nucleic acid molecule and collagen
TW200813091A (en) * 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
US10787670B2 (en) 2016-09-15 2020-09-29 Labcyte Inc. High-efficiency transfection of biological cells using sonoporation
CA3078630A1 (en) 2017-10-12 2019-04-18 Sutrovax, Inc. Periodontitis vaccine and related compositions and method of use
JP7307062B2 (ja) 2017-11-22 2023-07-11 ラブサイト インコーポレイテッド 連続流動サンプリングプローブを使用する分析器具の音響装填のためのシステムおよび方法
CN112236519A (zh) 2018-03-03 2021-01-15 拉伯塞特股份有限公司 使用声学液滴喷射从样品中提取目标部分的***和方法
WO2020205584A1 (en) 2019-04-02 2020-10-08 Vaxcyte, Inc. Optimized cell-free synthesis of invasion plasmid antigen b and related compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631270A (en) * 1978-11-20 1986-12-23 Research Corporation Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
DK182289D0 (da) * 1989-04-14 1989-04-14 Francesco Blasi Modifikation af proteiner
US5039791A (en) * 1989-11-06 1991-08-13 Monsanto Company Peptide fragments of tissue plasminogen activator
GB2246779B (en) * 1990-08-03 1994-08-17 Delta Biotechnology Ltd Tumour-associated protease inhibitors targeted to tumour cells
WO1993009808A1 (en) * 1991-11-18 1993-05-27 The Regents Of The University Of Michigan METHODS FOR DETECTING AND ISOLATING uPA-R AND INHIBITING THE BINDING OF uPA TO uPA-R
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors

Also Published As

Publication number Publication date
FI955720A (fi) 1995-11-27
JPH08510742A (ja) 1996-11-12
AU682877B2 (en) 1997-10-23
WO1994028014A2 (en) 1994-12-08
DE69419623D1 (de) 1999-08-26
EP0745092B1 (de) 1999-07-21
NZ267291A (en) 1997-09-22
JPH11240897A (ja) 1999-09-07
NO954722L (no) 1995-11-22
FI955720A0 (fi) 1995-11-27
NO954722D0 (no) 1995-11-22
AU6954294A (en) 1994-12-20
US5679782A (en) 1997-10-21
WO1994028014A3 (en) 1995-01-26
DE69419623T2 (de) 1999-12-02
KR960702846A (ko) 1996-05-23
CA2163741A1 (en) 1994-12-08
US5656726A (en) 1997-08-12
EP0745092A1 (de) 1996-12-04

Similar Documents

Publication Publication Date Title
ATE182336T1 (de) Peptidinhibitoren der urokinaserezeptor-aktivität
DE69418181D1 (de) Cytokine dämpfende substanzen
ATE170868T1 (de) Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ATE271041T1 (de) Analoga von duocarmycin and cc-1065
ATE79273T1 (de) Stabilisierte zusammensetzungen von menschlichen aktivatoren des gewebeplasminogens.
TR200000272T2 (tr) Antitümör ve antimetastaz maddeleri olarak o-ikameli hidrosikumaranon türevleri.
DE69333639D1 (en) Trypsininhibitoren
BR9612360A (pt) Inibidores de amidino protease
SE9300012D0 (sv) New peptides
DE69432608D1 (de) Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp
ES2088128T3 (es) Aminosulfonilureas inhibidoras de acat.
FR2694296B1 (fr) Peptides inhibant l'activité des protéines ras, préparation et utilisation.
HUT70579A (en) Bifunctional urocinase-variants having improved fibrinolytic properties and thrombin-inhibiting activity
NO980296D0 (no) Forbedrede terapeutiske midler
ATE57526T1 (de) P-acylaminobenzamide.
ES2103482T3 (es) Antigeno de linfocitos t citotoxicos utilizado como inhibidor de la cisteina proteasa.
BR9608978A (pt) Inibidor de protease de serina derivado de imidazo [1,5a] piridina composição farmacêutica e utilização do inibidor de protease
ITBO930092V0 (it) perfezionamento ad un elettrodo ad ancoraggio attivo per elettroca- teteri.
ITMI912683A1 (it) Clonaggio e sequenziamento dell'operone srfa di bacillus subtilis che codifica il complesso multienzimatico surfattina sintetasi

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties