ATE17480T1 - Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene. - Google Patents

Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene.

Info

Publication number
ATE17480T1
ATE17480T1 AT83101247T AT83101247T ATE17480T1 AT E17480 T1 ATE17480 T1 AT E17480T1 AT 83101247 T AT83101247 T AT 83101247T AT 83101247 T AT83101247 T AT 83101247T AT E17480 T1 ATE17480 T1 AT E17480T1
Authority
AT
Austria
Prior art keywords
diaryl
analagic
inflammatory
halo
thiophene
Prior art date
Application number
AT83101247T
Other languages
English (en)
Inventor
Stephen Barry Haber
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of ATE17480T1 publication Critical patent/ATE17480T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Measuring Volume Flow (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
AT83101247T 1982-03-03 1983-02-10 Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene. ATE17480T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35430082A 1982-03-03 1982-03-03
EP83101247A EP0087629B1 (de) 1982-03-03 1983-02-10 Entzündungshemmende und/oder Schmerzstillende 2,3-Diaryl-5-halo thiophene

Publications (1)

Publication Number Publication Date
ATE17480T1 true ATE17480T1 (de) 1986-02-15

Family

ID=23392697

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83101247T ATE17480T1 (de) 1982-03-03 1983-02-10 Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene.

Country Status (18)

Country Link
EP (1) EP0087629B1 (de)
JP (1) JPS58159489A (de)
AT (1) ATE17480T1 (de)
AU (1) AU553269B2 (de)
CA (1) CA1242725A (de)
DE (1) DE3361812D1 (de)
DK (1) DK161320C (de)
ES (1) ES8403884A1 (de)
FI (1) FI79308C (de)
GR (1) GR78135B (de)
IE (1) IE54816B1 (de)
IL (1) IL67940A (de)
NO (1) NO155198B (de)
NZ (1) NZ203317A (de)
PH (1) PH18061A (de)
PT (1) PT76247B (de)
SU (1) SU1250172A3 (de)
ZA (1) ZA831046B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346175A1 (de) * 1983-12-21 1985-07-11 Merck Patent Gmbh, 6100 Darmstadt Pyridylthiophene
NZ211146A (en) * 1984-02-29 1987-10-30 Merck & Co Inc 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
US6492413B2 (en) 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
AU6027694A (en) * 1993-01-15 1994-08-15 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
GB9420616D0 (en) * 1994-10-12 1994-11-30 Merck Sharp & Dohme Method, compositions and use
CA2161789A1 (en) * 1993-05-13 1994-11-24 Jacques Yves Gauthier 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5840746A (en) * 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DE10001166A1 (de) 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
AUPR283801A0 (en) * 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302461A (en) * 1979-08-09 1981-11-24 E. I. Du Pont De Nemours And Company Antiinflammatory 5-substituted-2,3-diarylthiophenes
JPS6028837B2 (ja) * 1979-08-09 1985-07-06 イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− ジアリ−ルチオフエン化合物、その製造法およびそれを含有する抗炎症剤
US4381311A (en) * 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols

Also Published As

Publication number Publication date
ES520218A0 (es) 1984-04-01
NO155198B (no) 1986-11-17
AU1146083A (en) 1983-09-08
GR78135B (de) 1984-09-26
ZA831046B (en) 1984-09-26
DK67683A (da) 1983-09-04
JPH0314312B2 (de) 1991-02-26
IE54816B1 (en) 1990-02-14
AU553269B2 (en) 1986-07-10
DK161320C (da) 1991-12-09
FI79308B (fi) 1989-08-31
NO830527L (no) 1983-09-05
ES8403884A1 (es) 1984-04-01
FI830523A0 (fi) 1983-02-16
PH18061A (en) 1985-03-18
SU1250172A3 (ru) 1986-08-07
DE3361812D1 (en) 1986-02-27
IL67940A0 (en) 1983-06-15
PT76247B (en) 1986-02-04
EP0087629A3 (en) 1983-10-19
NZ203317A (en) 1985-07-12
EP0087629A2 (de) 1983-09-07
JPS58159489A (ja) 1983-09-21
EP0087629B1 (de) 1986-01-15
DK161320B (da) 1991-06-24
IE830331L (en) 1983-09-03
FI830523L (fi) 1983-09-04
CA1242725A (en) 1988-10-04
FI79308C (fi) 1989-12-11
IL67940A (en) 1986-02-28
DK67683D0 (da) 1983-02-16
PT76247A (en) 1983-03-01

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