ATE171170T1 - 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents

7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen

Info

Publication number
ATE171170T1
ATE171170T1 AT95923666T AT95923666T ATE171170T1 AT E171170 T1 ATE171170 T1 AT E171170T1 AT 95923666 T AT95923666 T AT 95923666T AT 95923666 T AT95923666 T AT 95923666T AT E171170 T1 ATE171170 T1 AT E171170T1
Authority
AT
Austria
Prior art keywords
taxol
ether
compounds
cancer
pharmaceutical compositions
Prior art date
Application number
AT95923666T
Other languages
English (en)
Inventor
Robert C Kelly
Ilse Gebhard
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE171170T1 publication Critical patent/ATE171170T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
AT95923666T 1994-06-28 1995-06-07 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen ATE171170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26817994A 1994-06-28 1994-06-28

Publications (1)

Publication Number Publication Date
ATE171170T1 true ATE171170T1 (de) 1998-10-15

Family

ID=23021820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95923666T ATE171170T1 (de) 1994-06-28 1995-06-07 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen

Country Status (12)

Country Link
EP (1) EP0767786B1 (de)
JP (1) JPH10502077A (de)
CN (1) CN1151740A (de)
AT (1) ATE171170T1 (de)
AU (1) AU2814595A (de)
CA (1) CA2191224A1 (de)
DE (1) DE69504843T2 (de)
DK (1) DK0767786T3 (de)
ES (1) ES2123996T3 (de)
MX (1) MX9700026A (de)
NZ (1) NZ288802A (de)
WO (1) WO1996000724A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6040466A (en) * 1996-03-25 2000-03-21 Rhone Poulenc Rorer Sa Taxoids, their preparation and pharmaceutical compositions containing them
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
US6232477B1 (en) 1996-03-25 2001-05-15 Aventis Pharma S.A. Methods of preparing new taxoids and pharmaceutical compositions containing them
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
DE19605024A1 (de) * 1996-01-31 1997-08-07 Schering Ag Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
JP2000510148A (ja) * 1996-05-16 2000-08-08 ブリストル―マイヤーズ スクイブ カンパニー ７―ｏ―メトキシメチルパクリタキセル
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
EP1301500B1 (de) 2000-06-22 2007-11-21 Nitromed, Inc. Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
TW200300416A (en) * 2001-11-27 2003-06-01 Bristol Myers Squibb Co Method of synthesizing a paclitaxel derivative
SG195018A1 (en) * 2011-06-06 2013-12-30 Arbor Therapeutics Llc Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN103980232A (zh) * 2014-06-05 2014-08-13 北京诺普德医药科技有限公司 10-乙酰基多西紫杉醇及其用途
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
CN107021943B (zh) * 2016-02-02 2020-12-29 中国科学院上海药物研究所 一类7-epi-巴卡亭III衍生物，及其制备方法和用途
CN113698369A (zh) * 2021-08-31 2021-11-26 无锡紫杉药业有限公司 一种除去卡巴他赛中特定单杂的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs

Also Published As

Publication number Publication date
DE69504843T2 (de) 1999-02-11
AU2814595A (en) 1996-01-25
EP0767786A1 (de) 1997-04-16
DK0767786T3 (da) 1999-06-14
CA2191224A1 (en) 1996-01-11
JPH10502077A (ja) 1998-02-24
DE69504843D1 (de) 1998-10-22
WO1996000724A1 (en) 1996-01-11
ES2123996T3 (es) 1999-01-16
EP0767786B1 (de) 1998-09-16
MX9700026A (es) 1997-04-30
NZ288802A (en) 1998-05-27
CN1151740A (zh) 1997-06-11

Similar Documents

Publication Publication Date Title
ATE226576T1 (de) 7-halo-und 7(beta), 8(beta)-methano-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
ATE171170T1 (de) 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
MY130544A (en) Antineoplastic use and pharmaceutical compositions containing them
PL367682A1 (en) Dolastatin 10 derivatives
NO953796L (no) Antitumor-forbindelser, farmasöytiske blandinger, fremgangsmåter for fremstilling derav og for behandling
YU23202A (sh) Lekovi za tretman malignih tumora
IL148782A0 (en) Drugs for the treatment of malignant tumours
ATE262515T1 (de) Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
TR200402454T4 (tr) C-4 karbonat taksanlar.
IL172538A0 (en) Depsipeptide compounds, pharmaceutical compositions containing the same and processes for the preparation thereof
MXPA03008018A (es) Metodos para preparar taxoides novedosos y composiciones farmaceuticas que los contienen.
MX9702671A (es) Derivados metalocenicos de diariletileno, metodos de preparacion y composiciones farmaceuticas que contienen estos derivados.
MXPA02010813A (es) Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor.
WO1992015601A3 (en) Heteroanthracycline antitumor analogs
TH14976EX (th) วิธีใช้สารต้านเนื้องอก 7-เฮโล-และ 78-เมธาโน-แทกซอลล์ และสารผสมทางเภสัชศาสตร์ที่ประกอบด้วยสารเหล่านั้น
DE60203740D1 (de) Luminacine analoge und deren verwendung
TH14976A (th) วิธีใช้สารต้านเนื้องอก 7-เฮโล-และ 78-เมธาโน-แทกซอลล์ และสารผสมทางเภสัชศาสตร์ที่ประกอบด้วยสารเหล่านั้น
NO924781L (no) Heterocykliske antracyklion- og antracyklin-analoger

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee