ATE159524T1 - Substituierte indole als angiotensin ii antagonisten - Google Patents

Substituierte indole als angiotensin ii antagonisten

Info

Publication number
ATE159524T1
ATE159524T1 AT93906123T AT93906123T ATE159524T1 AT E159524 T1 ATE159524 T1 AT E159524T1 AT 93906123 T AT93906123 T AT 93906123T AT 93906123 T AT93906123 T AT 93906123T AT E159524 T1 ATE159524 T1 AT E159524T1
Authority
AT
Austria
Prior art keywords
lower alkyl
hydrogen
angiotensin
antagonists
halogen
Prior art date
Application number
AT93906123T
Other languages
English (en)
Inventor
Lawrence E Fisher
David E Clarke
Alam Jahangir
Robin D Clark
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/882,390 external-priority patent/US5212195A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE159524T1 publication Critical patent/ATE159524T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
AT93906123T 1992-05-13 1993-02-26 Substituierte indole als angiotensin ii antagonisten ATE159524T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/882,390 US5212195A (en) 1992-05-13 1992-05-13 Substituted indole antagonists derivatives which are angiotensin II
US08/004,869 US5380739A (en) 1992-05-13 1993-02-04 Substituted indole derivatives

Publications (1)

Publication Number Publication Date
ATE159524T1 true ATE159524T1 (de) 1997-11-15

Family

ID=26673598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906123T ATE159524T1 (de) 1992-05-13 1993-02-26 Substituierte indole als angiotensin ii antagonisten

Country Status (17)

Country Link
EP (1) EP0640080B1 (de)
JP (1) JP3332234B2 (de)
CN (1) CN1039714C (de)
AT (1) ATE159524T1 (de)
AU (1) AU672599B2 (de)
CA (1) CA2135605A1 (de)
DE (1) DE69314786T2 (de)
DK (1) DK0640080T3 (de)
ES (1) ES2110086T3 (de)
FI (1) FI110512B (de)
GR (1) GR3025118T3 (de)
HU (2) HU221616B1 (de)
IL (1) IL104869A (de)
MX (1) MX9301088A (de)
NO (1) NO308535B1 (de)
NZ (2) NZ299146A (de)
WO (1) WO1993023391A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569539B2 (en) 1996-10-30 2003-05-27 Tetra Level Holdings & Finance S.A. Gas barrier packaging laminate method for production thereof and packaging containers
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
CN1299347A (zh) * 1998-02-25 2001-06-13 遗传研究所有限公司 磷脂酶抑制剂
AU1887401A (en) * 1999-12-14 2001-06-25 Nippon Shinyaku Co. Ltd. Medicinal composition
WO2002048155A1 (de) * 2000-12-14 2002-06-20 Clariant Gmbh Verfahren zur herstellung von formylphenylboronsäuren
HUP0401920A3 (en) * 2001-09-28 2005-10-28 Kumiai Chemical Industry Co Process for producing (2-nitrophenyl)acetonitrile derivatives and intermediates thereof
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6797708B2 (en) 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
GT200600228A (es) 2005-05-27 2006-12-26 Inhibidores de la fosfolipasa a2 citosolica
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
CN101981006B (zh) * 2008-01-31 2013-08-28 赛诺菲-安万特 环状吲哚-3-甲酰胺、其制备和其作为药物的用途
PT2240482E (pt) * 2008-01-31 2013-09-06 Sanofi Sa Azaindole-3-carboxamidas cíclicas, sua preparação e sua utilização como fármacos
CN101940568B (zh) * 2010-08-17 2012-11-14 合肥博太医药生物技术发展有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用
CN107056781A (zh) * 2017-05-18 2017-08-18 康化（上海）新药研发有限公司 一种(E)‑5‑甲基‑1H‑吡咯并[2,3‑b]吡啶‑3‑甲醛肟的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5124335A (en) * 1991-01-30 1992-06-23 Merck & Co., Inc. Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists

Also Published As

Publication number Publication date
FI945319A (fi) 1994-11-11
CN1039714C (zh) 1998-09-09
HUT68056A (en) 1995-05-29
DE69314786D1 (de) 1997-11-27
WO1993023391A1 (en) 1993-11-25
CA2135605A1 (en) 1993-11-25
EP0640080B1 (de) 1997-10-22
EP0640080A1 (de) 1995-03-01
FI110512B (fi) 2003-02-14
HU210709A9 (en) 1995-06-28
MX9301088A (es) 1993-11-01
AU3727493A (en) 1993-12-13
FI945319A0 (fi) 1994-11-11
NZ299146A (en) 2000-06-23
NO944311L (no) 1994-11-14
IL104869A0 (en) 1993-06-10
NO308535B1 (no) 2000-09-25
DE69314786T2 (de) 1998-02-19
IL104869A (en) 1997-11-20
JP3332234B2 (ja) 2002-10-07
ES2110086T3 (es) 1998-02-01
NO944311D0 (no) 1994-11-11
HU221616B1 (hu) 2002-12-28
CN1078469A (zh) 1993-11-17
JPH07506826A (ja) 1995-07-27
DK0640080T3 (da) 1998-05-25
GR3025118T3 (en) 1998-01-30
AU672599B2 (en) 1996-10-10
NZ249729A (en) 1996-12-20

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee