ATE131812T1 - Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie - Google Patents

Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie

Info

Publication number
ATE131812T1
ATE131812T1 AT89830055T AT89830055T ATE131812T1 AT E131812 T1 ATE131812 T1 AT E131812T1 AT 89830055 T AT89830055 T AT 89830055T AT 89830055 T AT89830055 T AT 89830055T AT E131812 T1 ATE131812 T1 AT E131812T1
Authority
AT
Austria
Prior art keywords
acetyl
melatonine
methoxytriptamine
order
total synthesis
Prior art date
Application number
AT89830055T
Other languages
English (en)
Inventor
Franco Fraschini
Bella Luigi Di
Ermanno Duranti
Original Assignee
I F L O S A S Di Giorgio E Ald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT19549/88A external-priority patent/IT1217344B/it
Priority claimed from IT8821872A external-priority patent/IT1230493B/it
Application filed by I F L O S A S Di Giorgio E Ald filed Critical I F L O S A S Di Giorgio E Ald
Application granted granted Critical
Publication of ATE131812T1 publication Critical patent/ATE131812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT89830055T 1988-02-25 1989-02-16 Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie ATE131812T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19549/88A IT1217344B (it) 1988-02-25 1988-02-25 Farmaco per la cura delle sindrome di immunodeficienza acquisita
IT8821872A IT1230493B (it) 1988-09-08 1988-09-08 Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da

Publications (1)

Publication Number Publication Date
ATE131812T1 true ATE131812T1 (de) 1996-01-15

Family

ID=26327207

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89830055T ATE131812T1 (de) 1988-02-25 1989-02-16 Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie

Country Status (7)

Country Link
US (2) US5122535A (de)
EP (1) EP0330625B1 (de)
JP (1) JP2724493B2 (de)
AT (1) ATE131812T1 (de)
DE (1) DE68925135T2 (de)
ES (1) ES2083390T3 (de)
GR (1) GR3019365T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2830010A1 (fr) * 2001-09-27 2003-03-28 Atofina Procede de preparation de n-(omega-bromoalkyl)phtalimides
FR2830011A1 (fr) * 2001-09-27 2003-03-28 Atofina Procede de preparation de n-(omega-bromoalkyl)phtalimides
KR100411599B1 (ko) * 2001-10-23 2003-12-18 동방에프티엘 주식회사 5-치환된 인돌 유도체의 제조방법
US20050020666A1 (en) * 2003-07-25 2005-01-27 Dabur Research Foundation Cardioprotective agents
JP5868980B2 (ja) * 2010-09-14 2016-02-24 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ トリプタミン誘導体、その製造方法および胃疾患についての使用
CN110818610B (zh) * 2019-12-06 2021-03-23 杭州志源生物科技有限公司 褪黑素的制备方法
CN115010645B (zh) * 2022-06-21 2023-08-29 广西师范大学 一种褪黑素的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2248155A (en) * 1938-06-28 1941-07-08 Merck & Co Inc Process for the production of indole acids
US2416258A (en) * 1944-03-17 1947-02-18 Purdue Research Foundation 3-(5-ethoxy-3-indolyl)-propyl compounds
CH585199A5 (de) * 1972-09-15 1977-02-28 Siegfried Ag
DE3105850A1 (de) * 1981-02-18 1982-08-19 Horst, Hans Jörg, Priv.Doz.Dr., 2057 Reinbek Mittel zum behandeln von tumoren

Also Published As

Publication number Publication date
DE68925135D1 (de) 1996-02-01
JP2724493B2 (ja) 1998-03-09
JPH023680A (ja) 1990-01-09
ES2083390T3 (es) 1996-04-16
EP0330625A3 (de) 1991-09-18
GR3019365T3 (en) 1996-06-30
US5122535A (en) 1992-06-16
USRE35631E (en) 1997-10-14
EP0330625B1 (de) 1995-12-20
EP0330625A2 (de) 1989-08-30
DE68925135T2 (de) 1996-08-01

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee