ATE127851T1 - Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz. - Google Patents

Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.

Info

Publication number
ATE127851T1
ATE127851T1 AT90123922T AT90123922T ATE127851T1 AT E127851 T1 ATE127851 T1 AT E127851T1 AT 90123922 T AT90123922 T AT 90123922T AT 90123922 T AT90123922 T AT 90123922T AT E127851 T1 ATE127851 T1 AT E127851T1
Authority
AT
Austria
Prior art keywords
active substance
indicator
peroxidatively active
assay
improved
Prior art date
Application number
AT90123922T
Other languages
English (en)
Inventor
Michael J Pugia
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE127851T1 publication Critical patent/ATE127851T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/10—Benzidines
    • C12Q2326/12—3,3',5,5'-Tetramethylbenzidine, i.e. TMB
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
AT90123922T 1990-01-30 1990-12-12 Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz. ATE127851T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/472,295 US5318894A (en) 1990-01-30 1990-01-30 Composition, device and method of assaying for peroxidatively active substances

Publications (1)

Publication Number Publication Date
ATE127851T1 true ATE127851T1 (de) 1995-09-15

Family

ID=23874919

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90123922T ATE127851T1 (de) 1990-01-30 1990-12-12 Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.

Country Status (11)

Country Link
US (2) US5318894A (de)
EP (1) EP0444263B1 (de)
JP (1) JP2922003B2 (de)
KR (1) KR0163793B1 (de)
AT (1) ATE127851T1 (de)
AU (1) AU623038B2 (de)
CA (1) CA2025803A1 (de)
DE (1) DE69022393T2 (de)
DK (1) DK0444263T3 (de)
ES (1) ES2078934T3 (de)
GR (1) GR3017415T3 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830765A (en) * 1993-09-22 1998-11-03 Ranpak Corp. Feline urinary tract disease-detecting paper cat litter and method
US5567621A (en) * 1993-07-14 1996-10-22 Shimadzu Corporation Method of and apparatus for analyzing nitrogen compound and phosphorus compound contained in water
US5702955A (en) * 1995-05-22 1997-12-30 Bayer Corporation Ascorbate resistant detection of hydrogen peroxide
CA2168625A1 (en) * 1996-02-01 1997-08-02 Francois Rousseau Method and device for specifically detecting myoglobin using a non-discriminating peroxidase-sensitive assay
US5885789A (en) * 1997-03-20 1999-03-23 Stc Technologies Incorporated Solution-based assay for peroxidatively-active substances in bodily fluids
SE9602818D0 (sv) * 1996-07-19 1996-07-19 Pharmacia & Upjohn Ab Colored composition
AU8334698A (en) 1997-07-15 1999-02-10 Kem-En-Tec A/S Pre-stained 3,3',5,5'-tetramethylbenzidine substrates for the detection of enzyme activity
US6121050A (en) * 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
CA2249778A1 (en) * 1997-12-15 1999-06-15 Bayer Corporation Competitive apo-peroxidase assay
ES2143434B1 (es) * 1998-09-16 2000-12-16 Cerrato Paula Jimenez Pañal con indicadores sensibles al estado de la orina que lo impregna visualiazables desde el exterior.
US6001656A (en) * 1998-09-28 1999-12-14 Bayer Corporation Method for the detection of creatinine
US6689618B1 (en) 2000-04-03 2004-02-10 Shuenn Tzong Chen Method and test strip of detecting oxidizing adulterant in urine
US6743597B1 (en) * 2000-06-13 2004-06-01 Lifescan, Inc. Compositions containing a urea derivative dye for detecting an analyte and methods for using the same
US7381797B2 (en) * 2001-05-09 2008-06-03 Surmodics, Inc. Stabilization of H2O2 under alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays
JP4618932B2 (ja) * 2001-05-28 2011-01-26 株式会社同仁化学研究所 塩素濃度の測定用組成物
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US20030170905A1 (en) * 2002-03-05 2003-09-11 Alexander Kamyshny Diagnostic beads for the detection of blood in animal excreta and a method for production thereof
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US8124367B2 (en) * 2005-02-28 2012-02-28 Miraculins, Inc. Device for applying a detector reagent to the skin for measuring cholesterol
WO2008137213A1 (en) * 2007-05-02 2008-11-13 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid onto a reagent surface
JP5422108B2 (ja) 2007-10-16 2014-02-19 栄研化学株式会社 ヘムタンパク質の安定化方法及び保存溶液
CA2623328A1 (en) * 2008-02-28 2009-08-28 Francois Mestrallet Mammalian disease detection system
US20130202499A1 (en) * 2012-01-31 2013-08-08 Kimberly-Clark Worldwide, Inc. Composition and Sensor for Detecting Occult Blood
WO2015027176A1 (en) 2013-08-22 2015-02-26 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
JP6288570B2 (ja) 2014-01-16 2018-03-07 ソニー株式会社 水溶性の蛍光色素または有色色素およびそれらの使用のための方法
US9091682B1 (en) 2014-05-01 2015-07-28 Steven M Hacker Tissue specimen bottle with color indicator in lid verifying and confirming presence of human tissue or blood contained in specimen bottle
WO2016138457A1 (en) 2015-02-26 2016-09-01 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
WO2016138461A1 (en) * 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
JP6849599B2 (ja) 2015-05-11 2021-03-24 ソニー株式会社 超明色ダイマーまたはポリマー染料
DE102016203335A1 (de) * 2016-03-01 2017-09-07 Axagarius Gmbh & Co. Kg Test zur Bestimmung einer Basen-Konzentration
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
CA3018564C (en) 2016-04-01 2024-04-23 Sony Corporation Ultra bright dimeric or polymeric fluorescent and colored dyes
RU2021124058A (ru) 2016-04-06 2021-09-10 Сони Корпорейшн Ультраяркие димерные или полимерные красители со спейсерными линкерными группами
EP3455238A1 (de) 2016-05-10 2019-03-20 Sony Corporation Ultrahelle polymere farbstoffe mit peptidgerüst
JP7068192B2 (ja) 2016-05-10 2022-05-16 ソニーグループ株式会社 ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用
JP7071286B2 (ja) 2016-05-11 2022-05-18 ソニーグループ株式会社 超明色ダイマーまたはポリマー染料
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
EP3491071A1 (de) 2016-07-29 2019-06-05 Sony Corporation Ultrahelle dimer- oder polymerfarbstoffe und verfahren zur herstellung davon
JP2020536847A (ja) 2017-10-05 2020-12-17 ソニー株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
EP4137818A1 (de) 2018-03-19 2023-02-22 Sony Group Corporation Verwendung von zweiwertigen metallen zur verstärkung von fluoreszenten signalen
EP3768689A1 (de) 2018-03-21 2021-01-27 Sony Corporation Polymere tandemfarbstoffe mit linkergruppen
JP2021529194A (ja) 2018-06-27 2021-10-28 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
WO2020139767A1 (en) * 2018-12-28 2020-07-02 Beckman Coulter, Inc. Methods for enhanced detection of hemoglobin
KR20230012097A (ko) 2019-09-26 2023-01-25 소니그룹주식회사 링커 그룹을 갖는 중합체성 탠덤 염료
CN111239124A (zh) * 2020-03-06 2020-06-05 中国药科大学 一种利用二硫化铂的过氧化氢比色检测法
CN113533704A (zh) * 2021-06-21 2021-10-22 南京市第一医院 一种呕吐物隐血检测装置及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE220142C (de) * 1908-11-27 1910-03-16
DE2235127C2 (de) * 1972-07-18 1974-08-08 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten
JPS6010261B2 (ja) * 1975-07-31 1985-03-15 和光純薬工業株式会社 潜血検出用組成物
NL7610608A (nl) * 1976-09-24 1978-03-29 Akzo Nv Werkwijze voor het stabiliseren van peroxidase- -bevattende composities.
US4288541A (en) * 1979-10-15 1981-09-08 Miles Laboratories, Inc. Ascorbate resistant composition, test device and method for detecting a component in a liquid test sample
US4251223A (en) * 1979-12-17 1981-02-17 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4310626A (en) * 1980-06-02 1982-01-12 Miles Laboratories, Inc. Interference-resistant composition, device and method for determining a peroxidatively active substance in a test sample
US4587220A (en) * 1983-03-28 1986-05-06 Miles Laboratories, Inc. Ascorbate interference-resistant composition, device and method for the determination of peroxidatively active substances
JPS6066994A (ja) * 1983-09-19 1985-04-17 Wako Pure Chem Ind Ltd 発色試液の安定化方法
US4615982A (en) * 1984-12-11 1986-10-07 Lawrence Paul J Fecal occult blood test

Also Published As

Publication number Publication date
CA2025803A1 (en) 1991-07-31
AU623038B2 (en) 1992-04-30
DK0444263T3 (da) 1995-12-04
EP0444263B1 (de) 1995-09-13
KR0163793B1 (ko) 1999-03-30
EP0444263A1 (de) 1991-09-04
US5362633A (en) 1994-11-08
JP2922003B2 (ja) 1999-07-19
ES2078934T3 (es) 1996-01-01
JPH04213063A (ja) 1992-08-04
DE69022393T2 (de) 1996-03-28
KR910014703A (ko) 1991-08-31
DE69022393D1 (de) 1995-10-19
US5318894A (en) 1994-06-07
AU6366190A (en) 1991-08-01
GR3017415T3 (en) 1995-12-31

Similar Documents

Publication Publication Date Title
ATE127851T1 (de) Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.
ATE113664T1 (de) Zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.
FI832756A0 (fi) Askorbatresistant, pao brett omraode verkande glukostestkomposition, testapparat och -metod
IE840741L (en) Composition for detecting peroxidatively active substance
DE69117588D1 (de) Zusammensetzung und Verfahren zur Bestimmung von Ketonkörpern
FI831688A0 (fi) Test foer esterasaktivitet i ett flytande specimen
FI850717L (fi) Iontesthjaelpmedel med poroes baermatris.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee