ATE125570T1 - Biokatalytisches verfahren zur herstellung von l- (-)-carnitin aus crotonobetain und stämme von proteeae zur verwendung in diesem verfahren. - Google Patents

Biokatalytisches verfahren zur herstellung von l- (-)-carnitin aus crotonobetain und stämme von proteeae zur verwendung in diesem verfahren.

Info

Publication number
ATE125570T1
ATE125570T1 AT91830195T AT91830195T ATE125570T1 AT E125570 T1 ATE125570 T1 AT E125570T1 AT 91830195 T AT91830195 T AT 91830195T AT 91830195 T AT91830195 T AT 91830195T AT E125570 T1 ATE125570 T1 AT E125570T1
Authority
AT
Austria
Prior art keywords
carnitine
strains
crotonobetain
proteeae
producing
Prior art date
Application number
AT91830195T
Other languages
English (en)
Inventor
Stuart Shapiro
Manrico Bernardini
Charles J Sih
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE125570T1 publication Critical patent/ATE125570T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/873—Proteus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT91830195T 1990-05-14 1991-05-13 Biokatalytisches verfahren zur herstellung von l- (-)-carnitin aus crotonobetain und stämme von proteeae zur verwendung in diesem verfahren. ATE125570T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47953A IT1240833B (it) 1990-05-14 1990-05-14 Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento

Publications (1)

Publication Number Publication Date
ATE125570T1 true ATE125570T1 (de) 1995-08-15

Family

ID=11263576

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91830195T ATE125570T1 (de) 1990-05-14 1991-05-13 Biokatalytisches verfahren zur herstellung von l- (-)-carnitin aus crotonobetain und stämme von proteeae zur verwendung in diesem verfahren.

Country Status (14)

Country Link
US (1) US5300430A (de)
EP (1) EP0457735B1 (de)
JP (1) JP3167739B2 (de)
KR (1) KR0135116B1 (de)
AT (1) ATE125570T1 (de)
CA (1) CA2042425C (de)
DE (1) DE69111511T2 (de)
DK (1) DK0457735T3 (de)
ES (1) ES2075408T3 (de)
HK (1) HK1005888A1 (de)
IE (1) IE62149B1 (de)
IT (1) IT1240833B (de)
PT (1) PT97659B (de)
ZA (1) ZA913530B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
ATE257515T1 (de) * 1993-10-08 2004-01-15 Lonza Ag Gene für den butyrobetain/crotonobetain-l- carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
EP0735143B1 (de) * 1995-03-28 1998-11-18 Tanabe Seiyaku Co., Ltd. Verfahren zur Herstellung von D-Aminosäuren
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
JP2002528468A (ja) 1998-10-27 2002-09-03 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ Ｌ−カルニチンの合成に有用な補酵素
US6337197B2 (en) * 1998-10-27 2002-01-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Coenzymes useful for the synthesis of L-carnitine
US6746530B2 (en) 2001-08-02 2004-06-08 Chunghwa Pictures Tubes, Ltd. High contrast, moisture resistant antistatic/antireflective coating for CRT display screen
EP1869199B1 (de) * 2005-04-15 2010-01-06 Council Of Scientific And Industrial Research Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino-beta-hydroxybuttersäure ((r)-gabob) und (r)-carnitin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
EP0320460B1 (de) * 1987-10-26 1994-04-27 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Verfahren zur Isolierung des Enzyms Karnitin-Hydrolyase von zur Familie der Enterobakteriaceae gehörenden Stämmen und Verwendung des immobilisierten Enzyms zur Herstellung von L(-)Karnitin
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento

Also Published As

Publication number Publication date
IT9047953A0 (it) 1990-05-14
IE911637A1 (en) 1991-11-20
ZA913530B (en) 1992-02-26
IE62149B1 (en) 1994-12-14
CA2042425C (en) 2000-07-11
US5300430A (en) 1994-04-05
CA2042425A1 (en) 1991-11-15
HK1005888A1 (en) 1999-01-29
KR910020171A (ko) 1991-12-19
IT9047953A1 (it) 1991-11-14
PT97659B (pt) 1998-09-30
JPH04228065A (ja) 1992-08-18
PT97659A (pt) 1992-05-29
IT1240833B (it) 1993-12-17
JP3167739B2 (ja) 2001-05-21
KR0135116B1 (ko) 1998-04-15
DE69111511D1 (de) 1995-08-31
DE69111511T2 (de) 1996-01-04
EP0457735B1 (de) 1995-07-26
EP0457735A1 (de) 1991-11-21
ES2075408T3 (es) 1995-10-01
DK0457735T3 (da) 1995-09-11

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee