ATE111524T1 - Mutanter stamm von einem methylotrophen organismus und verfahren zur herstellung eines proteins in methylotrophen organismus. - Google Patents

Mutanter stamm von einem methylotrophen organismus und verfahren zur herstellung eines proteins in methylotrophen organismus.

Info

Publication number
ATE111524T1
ATE111524T1 AT88121327T AT88121327T ATE111524T1 AT E111524 T1 ATE111524 T1 AT E111524T1 AT 88121327 T AT88121327 T AT 88121327T AT 88121327 T AT88121327 T AT 88121327T AT E111524 T1 ATE111524 T1 AT E111524T1
Authority
AT
Austria
Prior art keywords
methylotrophic
expression
protein
organism
methanol
Prior art date
Application number
AT88121327T
Other languages
English (en)
Inventor
Rainer O Dr Roggenkampe
Zbigniew A Dr Janowicz
Cornelis P Prof Dr Hollenberg
Original Assignee
Rhein Biotech Ges Fuer Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhein Biotech Ges Fuer Biotech filed Critical Rhein Biotech Ges Fuer Biotech
Application granted granted Critical
Publication of ATE111524T1 publication Critical patent/ATE111524T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT88121327T 1988-12-20 1988-12-20 Mutanter stamm von einem methylotrophen organismus und verfahren zur herstellung eines proteins in methylotrophen organismus. ATE111524T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88121327A EP0374282B1 (de) 1988-12-20 1988-12-20 Mutanter Stamm von einem methylotrophen Organismus und Verfahren zur Herstellung eines Proteins in methylotrophen Organismus

Publications (1)

Publication Number Publication Date
ATE111524T1 true ATE111524T1 (de) 1994-09-15

Family

ID=8199690

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88121327T ATE111524T1 (de) 1988-12-20 1988-12-20 Mutanter stamm von einem methylotrophen organismus und verfahren zur herstellung eines proteins in methylotrophen organismus.

Country Status (5)

Country Link
EP (1) EP0374282B1 (de)
JP (1) JPH02276568A (de)
AT (1) ATE111524T1 (de)
DE (1) DE3851535T2 (de)
ES (1) ES2065331T3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204261A (en) * 1991-04-24 1993-04-20 Phillips Petroleum Company Catalase-negative pichia pastoris
CA2101610A1 (en) * 1992-08-07 1994-02-08 William D. Prevatt Production of bacillus entomotoxins in methylotrophic yeast
JPH06209763A (ja) * 1993-01-13 1994-08-02 Green Cross Corp:The 変異株

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173378B1 (de) * 1984-07-27 1991-06-12 Unilever N.V. Verfahren zur Herstellung von einem Polypeptid mittels eines transformierten Mikroorganismus, ein dazu geeigneter transformierter Mikroorganismus, und zur Herstellung dieser Mikroorganismen geeignete DNS Sequenzen
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
EP0242007B1 (de) * 1986-11-24 1990-11-07 Unilever N.V. Verfahren zur Herstellung einer catalasefreien, Oxidase enthaltenden Hefe und deren Verwendung

Also Published As

Publication number Publication date
JPH02276568A (ja) 1990-11-13
ES2065331T3 (es) 1995-02-16
DE3851535T2 (de) 1995-02-02
EP0374282B1 (de) 1994-09-14
DE3851535D1 (de) 1994-10-20
EP0374282A1 (de) 1990-06-27

Similar Documents

Publication Publication Date Title
DE69637054T2 (de) Aus Bacillus stammende Transglutaminase
Matsuda et al. Dissociation of tetanus neurotoxin into two polypeptide fragments
ATE203769T1 (de) Dna, die aspartokinase iii-mutanten kodiert und ihre verwendung zur herstellung von l-threonin durch fermentation
ATE280235T1 (de) Plasmid zur herstellung von crm-protein und diphtherie-toxin
DE3586304D1 (de) Verfahren zur herstellung von proteinen und transformierten zellen und dna-konstruktionen zur korrektur von mankos und wirtszellen sowie deren herstellung und verwendung.
DE3486179D1 (de) Verfahren zur herstellung vielkettige polypeptide oder proteine.
AU2443488A (en) Dna-molecules coding for fmdh control regions and structured gene for a protein having fmdh-activity and their uses
CA2113551A1 (fr) Levures recombinantes hautement stables pour la production de proteines recombinantes
US5041378A (en) Procaryotic xylose isomerase muteins
EP1761557B1 (de) Neue, polyaminosäuren bildende oder abbauende genprodukte von bacillus licheniformis und darauf aufbauende verbesserte biotechnologische produktionsverfahren
EP0332120B1 (de) Strukturgen für membrangebundene Aldehyd-Dehydrogenase, Plasmid, das es enthält, mit diesem Plasmid transformierte Essigsäurebakterien und Essigsäuregärung mittels dieser Transformanten
AU3307797A (en) A method for increasing hemoprotein production in filamentous fungi
ES2093717T3 (es) Mutante de hirudina, su produccion, anticoagulante, vector secretor, microorganismo transformado por el indicado vector y produccion de un producto a partir de dicho microorganismo.
ATE111524T1 (de) Mutanter stamm von einem methylotrophen organismus und verfahren zur herstellung eines proteins in methylotrophen organismus.
DE68926893D1 (de) Verfahren zur Herstellung von clavulanic Säure
US7329521B2 (en) Transglutaminase-producing strain
ATE480624T1 (de) Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit
EP0521948B1 (de) $g(g)-CGTase
DE69225050T2 (de) Uricase kodierende DNA und Verfahren zur Herstellung von Uricase
DE3850456T2 (de) Klonierung des isoamylaseenzym kodierenden Gens und seine Verwendung zur Herstellung dieses Enzyms.
EP0625576A2 (de) Gen, welches autonome Replikation eines Plasmids in Coryneform-Bakterien Kodiert
KR910004811A (ko) 이종 단백질을 이.콜라이 내에서 제조하기 위한 최적 발효방법
DE69941789D1 (de) In vivo-verfahren zur herstellung von proteinen, die nicht-konventionelle aminosäuren enthalten
US5217880A (en) L-fucose dehydrogenase gene, microorganism having said gene and production of l-fucose dehydrogenase by the use of said microorganism
DE69231145T2 (de) Für eine Esterase kodierendes Gen und dieses Gen enthaltender Mikroorganismus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee