ATE102256T1 - Sonden aus nukleinsaeuren. - Google Patents
Sonden aus nukleinsaeuren.Info
- Publication number
- ATE102256T1 ATE102256T1 AT90900184T AT90900184T ATE102256T1 AT E102256 T1 ATE102256 T1 AT E102256T1 AT 90900184 T AT90900184 T AT 90900184T AT 90900184 T AT90900184 T AT 90900184T AT E102256 T1 ATE102256 T1 AT E102256T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- particles
- probes
- disclosed
- monodisperse
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888827167A GB8827167D0 (en) | 1988-11-21 | 1988-11-21 | In vitro mutagenesis |
GB888827157A GB8827157D0 (en) | 1988-11-21 | 1988-11-21 | Sequencing nucleic acids |
GB888827160A GB8827160D0 (en) | 1988-11-21 | 1988-11-21 | Detection & quantitative determination of rna & dna |
GB888827158A GB8827158D0 (en) | 1988-11-21 | 1988-11-21 | Process for producing cdna |
GB888827166A GB8827166D0 (en) | 1988-11-21 | 1988-11-21 | Obtention & purification of rna |
GB888827159A GB8827159D0 (en) | 1988-11-21 | 1988-11-21 | Subtraction cdna library construction |
GB898906643A GB8906643D0 (en) | 1989-03-22 | 1989-03-22 | Sequencing nucleic acids |
PCT/EP1989/001419 WO1990006045A2 (en) | 1988-11-21 | 1989-11-21 | Nucleic acid probes |
EP90900184A EP0446260B1 (de) | 1988-11-21 | 1989-11-21 | Sonden aus nukleinsäuren |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE102256T1 true ATE102256T1 (de) | 1994-03-15 |
Family
ID=27562808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90900184T ATE102256T1 (de) | 1988-11-21 | 1989-11-21 | Sonden aus nukleinsaeuren. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0446260B1 (de) |
JP (1) | JP3020271B2 (de) |
AT (1) | ATE102256T1 (de) |
AU (1) | AU640626B2 (de) |
CA (1) | CA2003508C (de) |
DE (1) | DE68913555T2 (de) |
WO (1) | WO1990006045A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015768A1 (en) * | 1990-04-06 | 1991-10-17 | Syngene, Inc. | Process and composition for performing dna assays |
US5660985A (en) * | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
WO1992005443A1 (en) * | 1990-09-15 | 1992-04-02 | Medical Research Council | Reagent separation |
US5665582A (en) * | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
JPH06510363A (ja) * | 1990-10-29 | 1994-11-17 | ディカルブ プラント ジェネティクス | 磁気性粒子を使用する生物学的材料の単離 |
US5734020A (en) * | 1991-11-20 | 1998-03-31 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
JPH08500722A (ja) * | 1992-01-29 | 1996-01-30 | 日立化成工業株式会社 | ポリヌクレオチド固定化担体 |
US6300058B1 (en) | 1992-01-29 | 2001-10-09 | Hitachi Chemical Research Center, Inc. | Method for measuring messenger RNA |
GB9212164D0 (en) * | 1992-06-09 | 1992-07-22 | Medical Res Council | Preparation of nucleic acids |
WO1994002636A1 (en) * | 1992-07-28 | 1994-02-03 | Hitachi Chemical Company Ltd. | Gene detection system |
US5580971A (en) * | 1992-07-28 | 1996-12-03 | Hitachi Chemical Company, Ltd. | Fungal detection system based on rRNA probes |
US5591841A (en) * | 1993-01-14 | 1997-01-07 | Ji; Huamin | Rapid purification of circular DNA by triplex-mediated affinity capture |
ES2055661B1 (es) * | 1993-01-20 | 1995-03-01 | Univ Malaga | Determinacion de la expresion genica por captura especifica de arn y su cuantificacion directa por electroforesis capilar en zona libre. |
GB9314394D0 (en) * | 1993-07-12 | 1993-08-25 | Slater James H | A security device using an ultrasensitive microtrace for protecting materials,articles and items |
US5683875A (en) * | 1995-05-04 | 1997-11-04 | Hewlett-Packard Company | Method for detecting a target nucleic acid analyte in a sample |
JP2965131B2 (ja) * | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
EP1260595B1 (de) * | 1995-07-07 | 2006-09-13 | Toyo Boseki Kabushiki Kaisha | Nukleinsäuren bindender magnetischer Träger und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung |
AU1811197A (en) * | 1996-02-25 | 1997-09-10 | Precision System Science Co., Ltd. | Method for treating biopolymers, microorganisms or materials by using more than one type of magnetic particles |
DE19610354C1 (de) * | 1996-03-15 | 1997-11-20 | Innova Gmbh | Vorrichtung, Verfahren und Einrichtung zur Isolierung von Nukleinsäuren |
FR2749082B1 (fr) * | 1996-05-24 | 1998-06-26 | Bio Merieux | Particules superparamagnetiques et monodispersees |
DE19622885A1 (de) * | 1996-06-07 | 1997-12-11 | Boehringer Mannheim Gmbh | Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette |
DE69836587T2 (de) * | 1997-04-16 | 2007-10-11 | Applera Corp., Foster City | Nukleinsäuresammlung |
DE69836012T2 (de) | 1997-05-02 | 2007-04-05 | Gen-Probe Inc., San Diego | Zwei-schritt hybridisierung und einfang von einem polynukleotid |
US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
EP0937497B9 (de) | 1997-12-25 | 2003-10-29 | Tosoh Corporation | Magnetischer Träger, seine Herstellung, und Verfahren zum Extrahieren von Nukleinsäuren |
FR2773416B1 (fr) | 1998-01-06 | 2000-02-11 | Bio Merieux | Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules |
US6297010B1 (en) * | 1998-01-30 | 2001-10-02 | Genzyme Corporation | Method for detecting and identifying mutations |
EP1121469A2 (de) * | 1998-10-12 | 2001-08-08 | Attomol GmbH Molekulare Diagnostika | Verfahren und kit zum direkten nachweis von nukleotidsequenzen, aminosäuresequenzen oder antigenen |
US5973138A (en) | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
DE19938372A1 (de) * | 1999-08-09 | 2001-03-08 | Diagnostikforschung Inst | Verfahren und Vorrichtung zur Trennung magnetischer Teilchen |
FR2803913B1 (fr) | 2000-01-13 | 2002-08-16 | Pasteur Sanofi Diagnostics | Procede d'immobilisation de reactif(s) affin(s) sur phase solide hydrophobe |
DE60138195D1 (de) * | 2000-08-21 | 2009-05-14 | Nat Inst Of Advanced Ind Scien | Magnetische partikel mit kritischer lösungstemperatur am unteren bereich |
US20030092029A1 (en) | 2001-06-06 | 2003-05-15 | Lee Josephson | Magneitc-nanoparticle conjugates and methods of use |
US9394332B2 (en) | 2002-08-29 | 2016-07-19 | Epigenomics Ag | Method for bisulfite treatment |
US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
CA2547743C (en) | 2003-12-02 | 2011-06-28 | F. Hoffmann-La Roche Ag | Improved method for bisulfite treatment |
TW201037080A (en) | 2003-12-25 | 2010-10-16 | Danform Kk | Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same |
CA2502549C (en) | 2004-04-23 | 2016-02-16 | Becton, Dickinson And Company | Use of an extraction control in a method of extracting nucleic acids |
JP4735926B2 (ja) * | 2004-05-27 | 2011-07-27 | アイシン精機株式会社 | 核酸の高効率回収方法 |
JP4710283B2 (ja) * | 2004-09-08 | 2011-06-29 | 富士レビオ株式会社 | 核酸配列の増幅法および検出法 |
US20090264635A1 (en) | 2005-03-25 | 2009-10-22 | Applera Corporation | Methods and compositions for depleting abundant rna transcripts |
JP5021629B2 (ja) | 2005-05-09 | 2012-09-12 | ザ ジェネラル ホスピタル コーポレイション | 水の緩和に基づくセンサ |
US7564245B2 (en) | 2005-08-31 | 2009-07-21 | T2 Biosystems, Inc. | NMR device for detection of analytes |
CA2622712A1 (en) * | 2005-09-16 | 2007-03-29 | Primera Biosystems, Inc. | Compositions and methods for purifying nucleic acids |
AU2007317787B2 (en) | 2006-11-08 | 2012-07-12 | T2 Biosystems, Inc. | NMR systems for in vivo detection of analytes |
US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
WO2009026164A1 (en) | 2007-08-17 | 2009-02-26 | The General Hospital Corporation | Magnetic resonance-based viscometers and methods |
US8421458B2 (en) | 2007-09-28 | 2013-04-16 | T2 Biosystems, Inc. | NMR diagnostics by means of a plastic sample container |
WO2009061481A1 (en) | 2007-11-06 | 2009-05-14 | T2 Biosystems, Inc. | Small magnet and rf coil for magnetic resonance relaxometry |
JP4545200B2 (ja) * | 2008-02-04 | 2010-09-15 | 積水メディカル株式会社 | 核酸固定用磁性粒子 |
EP2143496A1 (de) | 2008-07-09 | 2010-01-13 | F. Hoffmann-Roche AG | Lysereagenzformulierung mit magnetischen Partikeln in Tablettenform |
EP2348976B1 (de) | 2008-10-29 | 2020-12-02 | T2 Biosystems, Inc. | Nmr-nachweis der gerinnungszeit |
EP2189218A1 (de) | 2008-11-12 | 2010-05-26 | F. Hoffmann-Roche AG | Trennung in einer Mikrowell platte unter Zuhilfenahme des Deckels |
EP2371951A4 (de) | 2008-11-27 | 2012-07-18 | Riken | NEUARTIGES MutS-PROTEIN UND SEINE VERWENDUNG ZUR BESTIMMUNG VON MUTATIONEN |
CN103052713A (zh) * | 2010-07-07 | 2013-04-17 | 陶氏益农公司 | 官能化线性dna盒的生成及植物中量子点/纳米颗粒介导的投递 |
EP3974831A1 (de) | 2010-10-22 | 2022-03-30 | T2 Biosystems, Inc. | Verfahren zum nachweis eines bakteriums in einer vollblutprobe |
US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
EP2732046B1 (de) | 2011-07-13 | 2017-09-06 | T2 Biosystems, Inc. | Kernspinresonanzverfahren zur überwachung der bildung von blutgerinnseln |
WO2013035875A1 (ja) | 2011-09-08 | 2013-03-14 | 独立行政法人理化学研究所 | プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法 |
EP2748651B1 (de) | 2011-09-21 | 2017-08-30 | T2 Biosystems, Inc. | Nmr-verfahren für endotoxinanalyse |
WO2013158281A1 (en) | 2012-04-20 | 2013-10-24 | T2 Biosystems, Inc. | Compositions and methods for detection of candida species |
US9739733B2 (en) | 2012-12-07 | 2017-08-22 | T2 Biosystems, Inc. | Methods for monitoring tight clot formation |
CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU530410B2 (en) * | 1978-02-21 | 1983-07-14 | Sintef | Preparing aqueous emulsions |
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4775619A (en) * | 1984-10-16 | 1988-10-04 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
GB8507706D0 (en) * | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
DK171161B1 (da) * | 1985-03-28 | 1996-07-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve |
EP0224126A3 (de) * | 1985-11-25 | 1989-02-01 | The University of Calgary | Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren |
CA1304006C (en) * | 1985-12-20 | 1992-06-23 | Edwin F. Ullman | Particle separation method |
ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
ATE107654T1 (de) * | 1987-03-02 | 1994-07-15 | Gen Probe Inc | Polykationische träger zur reinigung, trennung und hybridisierung von nukleinsäure. |
JP2736467B2 (ja) * | 1987-10-26 | 1998-04-02 | デイド、インターナショナル、インコーポレイテッド | 磁気応答ポリマー粒子の製造法およびその応用 |
SE8704158L (sv) * | 1987-10-26 | 1989-04-27 | Carbomatrix Ab C O Ulf Schroed | Mikrosfaerer, foerfarande foer framstaellning daerav och anvaendning daerav |
AU620838B2 (en) * | 1987-10-26 | 1992-02-27 | Dade International Inc. | Process for producing magnetically responsive polymer particles and application thereof |
SE8801070D0 (sv) * | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
NO165894C (no) * | 1988-05-24 | 1991-04-24 | Gunnar Paulsen | Analysemetode for gener. |
-
1989
- 1989-11-21 DE DE68913555T patent/DE68913555T2/de not_active Expired - Lifetime
- 1989-11-21 JP JP2501005A patent/JP3020271B2/ja not_active Expired - Lifetime
- 1989-11-21 EP EP90900184A patent/EP0446260B1/de not_active Expired - Lifetime
- 1989-11-21 AU AU47586/90A patent/AU640626B2/en not_active Expired
- 1989-11-21 AT AT90900184T patent/ATE102256T1/de not_active IP Right Cessation
- 1989-11-21 CA CA002003508A patent/CA2003508C/en not_active Expired - Lifetime
- 1989-11-21 WO PCT/EP1989/001419 patent/WO1990006045A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE68913555D1 (de) | 1994-04-07 |
AU4758690A (en) | 1990-06-26 |
EP0446260A1 (de) | 1991-09-18 |
EP0446260B1 (de) | 1994-03-02 |
CA2003508A1 (en) | 1990-05-21 |
WO1990006045A2 (en) | 1990-06-14 |
CA2003508C (en) | 2000-01-25 |
WO1990006045A3 (en) | 1991-03-21 |
DE68913555T2 (de) | 1994-07-07 |
JP3020271B2 (ja) | 2000-03-15 |
AU640626B2 (en) | 1993-09-02 |
JPH04501959A (ja) | 1992-04-09 |
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