ATA582080A - Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-propionyl)-pyrrolidin-(2s)-carbons[ure - Google Patents

Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-propionyl)-pyrrolidin-(2s)-carbons[ure

Info

Publication number
ATA582080A
ATA582080A AT0582080A AT582080A ATA582080A AT A582080 A ATA582080 A AT A582080A AT 0582080 A AT0582080 A AT 0582080A AT 582080 A AT582080 A AT 582080A AT A582080 A ATA582080 A AT A582080A
Authority
AT
Austria
Prior art keywords
ure
pyrrolidin
propionyl
mercapto
carbons
Prior art date
Application number
AT0582080A
Other languages
English (en)
Other versions
AT375340B (de
Inventor
Janos Dr Fischer
Laszlo Chem Ing Rozsa
Anna Bakonyi
Gabor Dr Fazekas
Pal Dr Chem Ing Vago
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA582080A publication Critical patent/ATA582080A/de
Application granted granted Critical
Publication of AT375340B publication Critical patent/AT375340B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/38—Acyl halides
    • C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
    • C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0582080A 1979-12-29 1980-11-28 Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-propionyl)-pyrrolidin-(2s)-carbons[ure AT375340B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79EE2720A HU184082B (en) 1979-12-29 1979-12-29 Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid

Publications (2)

Publication Number Publication Date
ATA582080A true ATA582080A (de) 1983-12-15
AT375340B AT375340B (de) 1984-07-25

Family

ID=10995884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0582080A AT375340B (de) 1979-12-29 1980-11-28 Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-propionyl)-pyrrolidin-(2s)-carbons[ure

Country Status (21)

Country Link
US (1) US4332725A (de)
JP (1) JPS6058230B2 (de)
AT (1) AT375340B (de)
CA (1) CA1137499A (de)
CH (1) CH646423A5 (de)
CS (1) CS219935B2 (de)
DD (1) DD155898A5 (de)
DE (1) DE3049273C2 (de)
DK (1) DK157009C (de)
ES (1) ES497458A0 (de)
FI (1) FI67693C (de)
GB (1) GB2066252B (de)
GR (1) GR72303B (de)
HU (1) HU184082B (de)
NL (1) NL186960C (de)
NO (1) NO154307C (de)
PL (1) PL130249B1 (de)
PT (1) PT72222B (de)
SE (1) SE440350B (de)
SU (1) SU1139374A3 (de)
YU (1) YU43485B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4385062A (en) * 1980-01-09 1983-05-24 Gruppo Lepetit S.P.A. 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
DE3124091C2 (de) * 1981-06-19 1983-06-01 Degussa Ag, 6000 Frankfurt N-(3-Cyanopropanoyl)-aminocarbonsäureester und deren Verwendung
JPS58124764A (ja) * 1982-01-20 1983-07-25 Kanegafuchi Chem Ind Co Ltd 光学活性チオ−ル化合物の製造法
KR860001391B1 (ko) * 1984-07-23 1986-09-22 보령제약 주식회사 피롤리딘 유도체의 제조방법
KR870001570B1 (ko) * 1984-12-19 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
KR870001569B1 (ko) * 1985-02-11 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
HU196368B (en) * 1986-07-04 1988-11-28 Egyt Gyogyszervegyeszeti Gyar Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid
JPH026833A (ja) * 1988-06-24 1990-01-11 Nippon Alum Mfg Co Ltd 粉粒体混合装置
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
KR940005014B1 (ko) * 1991-11-07 1994-06-09 보령제약 주식회사 피롤리딘카르복실산 유도체의 제조방법
HUT64965A (en) * 1992-03-13 1994-03-28 Egyt Gyogyszervegyeszeti Gyar Process for the production of 2-imino-selenazolydes and medical preparations containing them
CN102452970A (zh) * 2010-10-16 2012-05-16 华中药业股份有限公司 D-3-溴-2-甲基丙酰-l-脯氨酸的制备方法
CN103086940B (zh) * 2011-10-28 2014-07-09 华中药业股份有限公司 一种1-(3-巯基-2-d-甲基丙酰基)-l-脯氨酸的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
US4181663A (en) * 1979-01-29 1980-01-01 E. R. Squibb & Sons, Inc. Selenium containing derivatives of proline and pipecolic acid
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4284561A (en) * 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids

Also Published As

Publication number Publication date
AT375340B (de) 1984-07-25
SE8008942L (sv) 1981-06-30
NO803939L (no) 1981-06-30
DE3049273A1 (de) 1981-12-24
YU43485B (en) 1989-08-31
CA1137499A (en) 1982-12-14
US4332725A (en) 1982-06-01
FI67693B (fi) 1985-01-31
YU325980A (en) 1983-01-21
HU184082B (en) 1984-06-28
ES8200340A1 (es) 1981-11-16
CH646423A5 (de) 1984-11-30
NL8006613A (nl) 1981-08-03
PL228689A1 (de) 1981-08-07
NO154307C (no) 1986-08-27
PT72222B (en) 1981-11-02
CS219935B2 (en) 1983-03-25
JPS6058230B2 (ja) 1985-12-19
GB2066252B (en) 1983-11-23
DE3049273C2 (de) 1985-06-05
GR72303B (de) 1983-10-18
PL130249B1 (en) 1984-07-31
DD155898A5 (de) 1982-07-14
NL186960B (nl) 1990-11-16
NL186960C (nl) 1991-04-16
DK553680A (da) 1981-06-30
FI67693C (fi) 1986-06-10
SE440350B (sv) 1985-07-29
FI804016L (fi) 1981-06-24
GB2066252A (en) 1981-07-08
PT72222A (en) 1981-01-01
ES497458A0 (es) 1981-11-16
DK157009C (da) 1990-03-26
NO154307B (no) 1986-05-20
DK157009B (da) 1989-10-30
SU1139374A3 (ru) 1985-02-07
JPS56100760A (en) 1981-08-12

Similar Documents

Publication Publication Date Title
AT373146B (de) Verfahren zur herstellung von tabletten
AT375340B (de) Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-propionyl)-pyrrolidin-(2s)-carbons[ure
ATA316578A (de) Verfahren zur herstellung von verklebungen
AT376674B (de) Verfahren zur herstellung von trans-8-fluor-5-
ATA18380A (de) Verfahren zur herstellung von hexahydronaphthacen-derivaten
AT363958B (de) Verfahren zur selektiven herstellung von isosorbid-5-nitrat
AT378003B (de) Verfahren zur herstellung von desactylcephalosporin c
AT362850B (de) Verfahren zur herstellung von holzleim
AT368497B (de) Verfahren zur herstellung von imidazolinen
ATA286983A (de) Verfahren zur herstellung von 7-benzoylindolin-2-onen
AT367387B (de) Verfahren zur herstellung von hexahydronaphthacen-derivaten
AT379161B (de) Verfahren zur herstellung von elastomer-duromer-verbundteilen
AT371800B (de) Verfahren zur herstellung von bromhexin
AT356080B (de) Verfahren zur herstellung von 1-(4-isopropyl- mercaptophenyl)-2-n-octylaminopropanol
AT375073B (de) Verfahren zur herstellung von 2-isopropylaminopyrimidin
AT375072B (de) Verfahren zur herstellung von 2-isopropylaminopyrimidin
AT374181B (de) Verfahren zur herstellung von 4-benzyl-alpha-(p
AT361226B (de) Verfahren zur herstellung von spanplatten
AT375942B (de) Verfahren zur herstellung von imidazobenzodiazepinderivaten
AT370716B (de) Verfahren zur herstellung von naphthacendionderivaten
ATA621080A (de) Verfahren zur herstellung von cephalosporans[urederivaten
AT374169B (de) Verfahren zur herstellung von alfa-6-desoxy-5 -hydroxytetracyclin
AT376963B (de) Verfahren zur herstellung von 5-halogenpyrimidinen
ATA332883A (de) Verfahren zur herstellung von humaninsulin
ATA486080A (de) Verfahren zur herstellung von nitrosobenzol

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee