AT355026B - Verfahren zur herstellung des (+)-(s)- enantiomeren von 3-(2-(4-(8-fluor-10,11- -dihydro-2-methyl-dibenzo(b,f)-thiepin- 10-yl)-1-piperazinyl)-aethyl)-2-oxazolidinon und dessen salzen - Google Patents

Verfahren zur herstellung des (+)-(s)- enantiomeren von 3-(2-(4-(8-fluor-10,11- -dihydro-2-methyl-dibenzo(b,f)-thiepin- 10-yl)-1-piperazinyl)-aethyl)-2-oxazolidinon und dessen salzen

Info

Publication number: AT355026B
Authority: AT; Austria
Prior art keywords: thiepin; oxazolidinone; dibenzo; fluor; enantiomer
Prior art date: 1975-06-06

Application number

AT409376A

Other languages

English (en)

Other versions

ATA409376A (de

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-06

Filing date

1976-06-03

Publication date

1980-02-11

1976-06-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1979-07-15 Publication of ATA409376A publication Critical patent/ATA409376A/de

1980-02-11 Application granted granted Critical

1980-02-11 Publication of AT355026B publication Critical patent/AT355026B/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT409376A 1975-06-06 1976-06-03 Verfahren zur herstellung des (+)-(s)- enantiomeren von 3-(2-(4-(8-fluor-10,11- -dihydro-2-methyl-dibenzo(b,f)-thiepin- 10-yl)-1-piperazinyl)-aethyl)-2-oxazolidinon und dessen salzen AT355026B (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH735375A CH611898A5 (de)	1975-06-06	1975-06-06
CH350676		1976-03-19

Publications (2)

Publication Number	Publication Date
ATA409376A ATA409376A (de)	1979-07-15
AT355026B true AT355026B (de)	1980-02-11

Family

ID=25693196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT409376A AT355026B (de)	1975-06-06	1976-06-03	Verfahren zur herstellung des (+)-(s)- enantiomeren von 3-(2-(4-(8-fluor-10,11- -dihydro-2-methyl-dibenzo(b,f)-thiepin- 10-yl)-1-piperazinyl)-aethyl)-2-oxazolidinon und dessen salzen

Country Status (21)

Country	Link
US (1)	US4089861A (de)
JP (1)	JPS51146487A (de)
AR (1)	AR211168A1 (de)
AT (1)	AT355026B (de)
AU (1)	AU499937B2 (de)
BE (1)	BE842593R (de)
CA (1)	CA1069506A (de)
CH (2)	CH613205A5 (de)
DD (1)	DD125779A6 (de)
DK (1)	DK244876A (de)
FI (1)	FI761411A (de)
FR (1)	FR2313062A2 (de)
GB (1)	GB1546241A (de)
HU (1)	HU173216B (de)
IE (1)	IE44228B1 (de)
LU (1)	LU75091A1 (de)
MC (1)	MC1105A1 (de)
NO (1)	NO761896L (de)
PL (1)	PL103423B1 (de)
SE (1)	SE7606387L (de)
SU (1)	SU637085A3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01149775A (ja) *	1987-12-07	1989-06-12	Kawaken Fine Chem Co Ltd	光学活性２−メチルピペラジンの製造方法
DE69527683T2 (de) *	1994-04-22	2003-04-10	Koei Chemical Co., Ltd.	Verfahren zur herstellung von optisch aktivem n-tert-butyl-2-piperazincarboxamidamid
US6159990A (en) *	1997-06-18	2000-12-12	Synaptic Pharmaceutical Corporation	Oxazolidinones as α1A receptor antagonists
WO1998057940A1 (en) *	1997-06-18	1998-12-23	Synaptic Pharmaceutical Corporation	Heterocyclic substituted piperidines and uses thereof
US6319932B1 (en)	1998-11-10	2001-11-20	Merck & Co., Inc.	Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en)	1998-11-10	2001-05-08	Merck & Co., Inc.	Oxazolidinones useful as alpha 1a adrenoceptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3954769A (en) *	1973-03-30	1976-05-04	Hoffman-La Roche Inc.	Dibenzo[b,f]thiepins
US3954764A (en) *	1973-03-30	1976-05-04	Hoffmann-La Roche Inc.	Dibenzo [b,f]thiepins bearing piperazinyl substitution
DD113545A5 (de) *	1973-03-30	1975-06-12
DE2412520C2 (de) *	1973-03-30	1982-09-16	F. Hoffmann-La Roche & Co. AG, 4002 Basel	Tricyclische Verbindungen, Verfahren zu deren Herstellung und diese enthaltende Präparate

1975
- 1975-06-06 CH CH44079A patent/CH613205A5/xx not_active IP Right Cessation
- 1975-06-06 CH CH735375A patent/CH611898A5/xx not_active IP Right Cessation
1976
- 1976-04-28 AU AU13423/76A patent/AU499937B2/en not_active Expired
- 1976-05-19 FI FI761411A patent/FI761411A/fi not_active Application Discontinuation
- 1976-05-20 HU HU76HO1906A patent/HU173216B/hu unknown
- 1976-05-26 US US05/690,325 patent/US4089861A/en not_active Expired - Lifetime
- 1976-05-31 IE IE1155/76A patent/IE44228B1/en unknown
- 1976-05-31 MC MC761198A patent/MC1105A1/xx unknown
- 1976-06-03 JP JP51064173A patent/JPS51146487A/ja active Pending
- 1976-06-03 DK DK244876A patent/DK244876A/da unknown
- 1976-06-03 AT AT409376A patent/AT355026B/de not_active IP Right Cessation
- 1976-06-04 BE BE167620A patent/BE842593R/xx active
- 1976-06-04 LU LU75091A patent/LU75091A1/xx unknown
- 1976-06-04 DD DD193199A patent/DD125779A6/xx unknown
- 1976-06-04 NO NO761896A patent/NO761896L/no unknown
- 1976-06-04 GB GB23182/76A patent/GB1546241A/en not_active Expired
- 1976-06-04 SE SE7606387A patent/SE7606387L/xx not_active Application Discontinuation
- 1976-06-04 CA CA254,151A patent/CA1069506A/en not_active Expired
- 1976-06-04 PL PL1976190139A patent/PL103423B1/pl unknown
- 1976-06-04 SU SU762365997A patent/SU637085A3/ru active
- 1976-06-04 FR FR7617013A patent/FR2313062A2/fr active Granted
1977
- 1977-03-09 AR AR266794A patent/AR211168A1/es active

Also Published As

Publication number	Publication date
US4089861A (en)	1978-05-16
IE44228B1 (en)	1981-09-23
NO761896L (de)	1976-12-07
HU173216B (hu)	1979-03-28
LU75091A1 (de)	1978-01-18
MC1105A1 (fr)	1977-02-04
SU637085A3 (ru)	1978-12-05
FI761411A (de)	1976-12-07
GB1546241A (en)	1979-05-23
PL103423B1 (pl)	1979-06-30
CA1069506A (en)	1980-01-08
ATA409376A (de)	1979-07-15
AR211168A1 (es)	1977-10-31
DD125779A6 (de)	1977-05-18
SE7606387L (sv)	1976-12-07
IE44228L (en)	1976-12-06
FR2313062A2 (fr)	1976-12-31
AU1342376A (en)	1977-11-03
AU499937B2 (en)	1979-05-03
BE842593R (fr)	1976-12-06
CH611898A5 (de)	1979-06-29
FR2313062B2 (de)	1978-12-15
CH613205A5 (de)	1979-09-14
JPS51146487A (en)	1976-12-16
DK244876A (da)	1976-12-07

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Legal Events

Date	Code	Title	Description
1983-08-15	ELJ	Ceased due to non-payment of the annual fee