AR241315A1 - Procedimiento para la obtencion de al menos uno de dos antigenos que respectivamente comportan una secuencia polipeptidica en comun con la glicoproteina de cubierta del virus lav. - Google Patents

Procedimiento para la obtencion de al menos uno de dos antigenos que respectivamente comportan una secuencia polipeptidica en comun con la glicoproteina de cubierta del virus lav.

Info

Publication number
AR241315A1
AR241315A1 AR86303661A AR30366186A AR241315A1 AR 241315 A1 AR241315 A1 AR 241315A1 AR 86303661 A AR86303661 A AR 86303661A AR 30366186 A AR30366186 A AR 30366186A AR 241315 A1 AR241315 A1 AR 241315A1
Authority
AR
Argentina
Prior art keywords
lav
ability
order
antigens
infectel
Prior art date
Application number
AR86303661A
Other languages
English (en)
Original Assignee
Inst Pasteur Ct Nat De La Rech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Pasteur Ct Nat De La Rech filed Critical Inst Pasteur Ct Nat De La Rech
Application granted granted Critical
Publication of AR241315A1 publication Critical patent/AR241315A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION, DE UNO DE LOS ANTIGENOS QUE RESPECTIVAMENTE COMPORTAN UNA SECUENCIA POLIPEPTIDICA EN COMUN CON LA GLICOPROTEINA DE CUBIERTA DEL VIRUS LAV Y QUE POSEEN PESOS MOLECULARES DEL ORDEN DE 135.000 Y 150.000, QUE COMPRENDE:-INFECTAR UNA LINEA DE CELULAS HIBRIDAS SENSIBLE A LA INFECCION POR EL VIRUS LAV Y QUE EXPRESAN EN SU SUPERFICIE LA MOLECULA T4, TAL COMO LA LINEA N° I-435 O UNA DERIVADA DE LA MISMA, HABIENDO SIDO ESTAS CELULAS HIBRIDAS PREVIAMENTE FORMADAS POR FUSION DE LINFOCITOS HUMANOS T4 Y CELULAS LINFOIDES TUMORALES, ESPECIFICAMENTE DEL TIPO MOLT-4;-CULTIVAR CELULAS HIBRIDAS INFECTADAS, RECUPERAR Y SOMETER A LISIS; SEPARAR Y RECUPERAR LOS ANTIGENOS DE PESOS MOLECULARES DEL ORDEN DE 150.000 O DEL ORDEN DE 135.000, O DE AMBOS A LA VEZ, QUE SON RECONOCIDOS POR SUEROS DE PACIENTES AFECTADOS POR UN SIDA O UN LAS DEBIDO AL VIRUS LAV O POR SUEROS DE PORTADORES ASINTOMATICOS DEL VIRUS LAV; LOS CUALES TIENEN LA CAPACIDAD DE FORMAR COMPLEJOS CON LA CONCANAV ALINA A, PUDIENDO ESTOS COMPLEJOS A CONTINUACION SER DISOCIADOS EN PRESENCIA 0-METIL-ALFA-D-MANNOPIRANOSIDA; TENIENDO LA CAPACIDAD DE FORMAR COMPLEJOS CON OTRAS LECTINAS, TALCOMO LAS CONOCIDAS BAJO LA DESIGNACION DE "LENTYL-LECTINAS"; SIENDO SENSIBLES A LA ACCION DE ENDOGLICOSIDASAS, PARTICULARMENTE DE LA ENDO-BETA-N-METILGLICOSAMINIDASA-H, SIENDO ESTA ACCION ACOMPANADA POR UNA FORMACION DE PROTEINAS CON UN PESO MOLECULAR DE ALREDEDOR DE 95.000; Y QUE TIENEN LA CAPACIDAD DE SER MARCADOS POR LA ¡C14¿ GLUCOSAMINA.
AR86303661A 1985-04-15 1986-04-15 Procedimiento para la obtencion de al menos uno de dos antigenos que respectivamente comportan una secuencia polipeptidica en comun con la glicoproteina de cubierta del virus lav. AR241315A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR858505676A FR2580177B2 (fr) 1985-04-15 1985-04-15 Antigenes apparentes a la glycoproteine d'enveloppe du virus du sida, notamment precurseurs de cette glycoproteine, procedes d'obtention de ces antigenes et moyens mis en oeuvre dans ces procedes, applications de ces antigenes a la preparation de compositions immunogenes ou pour le diagnostic du sida ou des affections qui lui sont apparentees

Publications (1)

Publication Number Publication Date
AR241315A1 true AR241315A1 (es) 1992-05-29

Family

ID=9318255

Family Applications (1)

Application Number Title Priority Date Filing Date
AR86303661A AR241315A1 (es) 1985-04-15 1986-04-15 Procedimiento para la obtencion de al menos uno de dos antigenos que respectivamente comportan una secuencia polipeptidica en comun con la glicoproteina de cubierta del virus lav.

Country Status (14)

Country Link
US (1) US5550052A (es)
EP (1) EP0206842A1 (es)
JP (1) JPS61286756A (es)
KR (1) KR860008275A (es)
AR (1) AR241315A1 (es)
AU (1) AU5612686A (es)
CA (1) CA1280072C (es)
DK (1) DK169986A (es)
FR (1) FR2580177B2 (es)
GR (1) GR860987B (es)
NZ (1) NZ215841A (es)
OA (1) OA08278A (es)
PT (1) PT82396B (es)
ZA (1) ZA862812B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725669A (en) * 1984-11-09 1988-02-16 President And Fellows Of Harvard College Assay for detecting infection by human T-cell lymphotropic virus-III
IE64785B1 (en) * 1985-04-08 1995-09-06 Genetic Systems Corp Expression of immunologically reactive viral proteins
JP2702911B2 (ja) * 1985-09-11 1998-01-26 ユナイテツド・バイオメデイカル・インコ−ポレ−テツド 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
JPS62182662A (ja) * 1986-02-06 1987-08-11 Fujirebio Inc ウイルス抗体検出用試薬
DK155886D0 (da) * 1986-04-04 1986-04-04 Bo Arne Hofmann Vaccine og fremgangsmaade til fremstilling af denne
IE63109B1 (en) * 1986-06-23 1995-03-22 Genetic Systems Corp Human monoclonal antibody to lymphadenopathy-associated virus
AU609447B2 (en) * 1987-02-19 1991-05-02 Nissin Shokuhin Kabushiki Kaisha Methods and materials for hiv detection and therapy
US5217895A (en) * 1987-02-19 1993-06-08 Nissin Shokuhin Kabushiki Kaisha Monoclonal anti-idiotypic antibodies specific for anti-T4 antibodies and cross-reactive with HIV
WO1988007058A1 (en) * 1987-03-16 1988-09-22 Biosolutions Pty. Ltd. Anti-paratopic antibody as an immunogen
IL95738A (en) * 1989-09-23 1996-11-14 Hoechst Ag Antibodies against the well-preserved amino acid sequences of insulin, a process for their preparation and use in immunoassay
FR2782168B1 (fr) * 1998-08-10 2000-11-03 Ass Pour Le Dev De La Biothera Nouvelles applications des sarcolectines et de leurs derives en diagnostic et therapeutique
US8405379B1 (en) 2008-09-18 2013-03-26 Luc Montagnier System and method for the analysis of DNA sequences in biological fluids
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
LT2691530T (lt) 2011-06-10 2018-08-10 Oregon Health & Science University Cmv glikoproteinai ir rekombinantiniai vektoriai
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675295A (en) * 1981-10-28 1987-06-23 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing subculturable lymphokine-producing human T cell hybridomas
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
AU583473B2 (en) * 1983-04-27 1989-05-04 President And Fellows Of Harvard College Method and products for detection of human t cell leukemia virus
EP0136798A3 (en) * 1983-08-25 1986-02-19 Biotech Research Laboratories Inc. Titre plate and assay kit for detection of antibodies in human serum and their production and use
US4665032A (en) * 1984-06-28 1987-05-12 Cornell Research Foundation, Inc. Human T cell hybridomas which produce immunosuppressive factors
US4725669A (en) * 1984-11-09 1988-02-16 President And Fellows Of Harvard College Assay for detecting infection by human T-cell lymphotropic virus-III
US4629783A (en) * 1985-04-29 1986-12-16 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease

Also Published As

Publication number Publication date
US5550052A (en) 1996-08-27
KR860008275A (ko) 1986-11-14
GR860987B (en) 1986-08-11
AU5612686A (en) 1986-10-23
ZA862812B (en) 1986-12-30
JPS61286756A (ja) 1986-12-17
DK169986D0 (da) 1986-04-15
PT82396A (fr) 1986-05-01
FR2580177B2 (fr) 1989-06-02
DK169986A (da) 1986-10-16
NZ215841A (en) 1991-04-26
OA08278A (fr) 1987-10-30
PT82396B (pt) 1988-08-17
EP0206842A1 (fr) 1986-12-30
FR2580177A2 (fr) 1986-10-17
CA1280072C (fr) 1991-02-12

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