AR240941A2 - Procedimiento para preparar compuestos de pirazolopirimidinas - Google Patents
Procedimiento para preparar compuestos de pirazolopirimidinasInfo
- Publication number
- AR240941A2 AR240941A2 AR30081585A AR30081585A AR240941A2 AR 240941 A2 AR240941 A2 AR 240941A2 AR 30081585 A AR30081585 A AR 30081585A AR 30081585 A AR30081585 A AR 30081585A AR 240941 A2 AR240941 A2 AR 240941A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- pyrazolo
- pyrimidines
- imidazo
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE PIRAZOLOPIRIRDINAS QUE TIENEN LA FORMULA I, DONDE R ES ALQUILO O TRIFLOURALQUILINO, R2 ES ALQUILO Y R3 ES HIDROGENO, ALQUILO O CICLOPROPILO; Y R4 Y R5 HIDROGENO O ALQUILO, PUDIENDO UNO DE R4 Y R5 SER ADEMAS DIALQUILO CUANDO EL OTRO H/H, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, PORQUE COMPRENDE TRATAR UN COMPUESTO QUE TIENE LA FORMULA II CON UN ORTOESTER QUE TIENE LA FORMULA R3 (OR)3 DONDE R1, R2, R3 Y R5 SON TAL COMO SE HAN DEFINIDO ANTERIORMENTE Y R ES ALQUILO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/381,484 US4469868A (en) | 1982-05-24 | 1982-05-24 | Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines |
Publications (2)
Publication Number | Publication Date |
---|---|
AR240941A2 true AR240941A2 (es) | 1991-03-27 |
AR240941A1 AR240941A1 (es) | 1991-03-27 |
Family
ID=23505215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR300815A AR240941A1 (es) | 1982-05-24 | 1985-06-26 | Procedimiento para preparar compuestos de pirazolopirimidinas |
Country Status (22)
Country | Link |
---|---|
US (1) | US4469868A (es) |
EP (1) | EP0095289B1 (es) |
JP (1) | JPS58210087A (es) |
KR (1) | KR870000931B1 (es) |
AR (1) | AR240941A1 (es) |
AT (1) | ATE24510T1 (es) |
AU (1) | AU553708B2 (es) |
CA (1) | CA1210393A (es) |
DE (1) | DE3368635D1 (es) |
DK (1) | DK161968C (es) |
ES (4) | ES8407051A1 (es) |
FI (1) | FI74012C (es) |
GR (1) | GR79262B (es) |
HK (1) | HK102989A (es) |
HU (1) | HU187913B (es) |
IE (1) | IE55111B1 (es) |
IL (1) | IL68360A (es) |
NO (1) | NO160444C (es) |
NZ (1) | NZ204321A (es) |
PH (1) | PH18454A (es) |
PT (1) | PT76745B (es) |
ZA (1) | ZA832637B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988000192A1 (en) * | 1986-06-26 | 1988-01-14 | Warner-Lambert Company | 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES |
CA2588627A1 (en) * | 2004-11-23 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them |
WO2006133261A2 (en) | 2005-06-06 | 2006-12-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
WO2010065148A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9763948B2 (en) | 2010-05-31 | 2017-09-19 | Intra-Cellular Therapies, Inc. | PDE1 inhibitory compounds and methods |
TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
JP6222776B2 (ja) * | 2011-04-21 | 2017-11-01 | オリゲニス ゲーエムベーハーOrigenis Gmbh | キナ−ゼ・インヒビタ−として有用なピラゾロ[4,3−d]ピリミジン |
WO2014060112A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
EP2956141A4 (en) | 2013-02-17 | 2016-10-26 | Intra Cellular Therapies Inc | NEW USES |
ES2836129T3 (es) | 2013-03-15 | 2021-06-24 | Intra Cellular Therapies Inc | Compuestos orgánicos |
US9545406B2 (en) | 2013-03-15 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Method of treating a CNS injury with a PDE1 inhibitor |
US9884872B2 (en) | 2014-06-20 | 2018-02-06 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
TWI686394B (zh) | 2014-08-07 | 2020-03-01 | 美商內胞醫療公司 | 有機化合物 |
BR112017005533B1 (pt) | 2014-09-17 | 2023-10-10 | Intra-Cellular Therapies, Inc | Compostos inibidores de fosfodiesterase 1 (pde1), composição farmacêutica que compreende os ditos compostos e usos dos mesmos no tratamento de uma doença, distúrbio, e/ou lesão do snc e no tratamento e/ou na profilaxia de uma doença, distúrbio e/ou lesão do snp |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
ES2906107T3 (es) | 2016-09-12 | 2022-04-13 | Intra Cellular Therapies Inc | Usos novedosos |
JP7401442B2 (ja) | 2018-01-31 | 2023-12-19 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH422807A (de) * | 1963-08-16 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung von Imidazo- und Pyrimidochinazolinen |
US3313815A (en) * | 1964-05-04 | 1967-04-11 | Sterling Drug Inc | 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same |
US3309369A (en) * | 1966-04-11 | 1967-03-14 | Wander Ag Dr A | Imidazo- and pyrimido-quinazolines |
US3594379A (en) * | 1968-09-16 | 1971-07-20 | Sandoz Ag | 2,3-dihydroimidazo(1,2-c)quinazolines |
DE2058501A1 (de) * | 1970-11-27 | 1972-05-31 | Bayer Ag | Verfahren zur Herstellung von neuen N-verbrueckten bicyclischen Heteroaromaten |
GB1347493A (en) * | 1971-02-11 | 1974-02-27 | Aspro Nicholas Ltd | Benzazine derivatives |
US3984556A (en) * | 1973-01-19 | 1976-10-05 | Sandoz, Inc. | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure |
JPS516993A (en) * | 1974-07-05 | 1976-01-20 | Dainippon Pharmaceutical Co | Adeninjudotaino seiho |
JPS5398997A (en) * | 1977-02-09 | 1978-08-29 | Sumitomo Chem Co Ltd | Fused pyridine derivertives and process for their preparation |
US4247553A (en) * | 1977-10-31 | 1981-01-27 | The Upjohn Company | Methods of treating psychosis |
US4206123A (en) * | 1977-10-31 | 1980-06-03 | Mccall John M | Isothiochroman |
US4250181A (en) * | 1977-10-31 | 1981-02-10 | The Upjohn Company | Methods of treating psychosis |
US4192803A (en) * | 1978-09-15 | 1980-03-11 | American Cyanamid Company | 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives |
EP0012208B1 (en) * | 1978-11-01 | 1983-01-26 | The Wellcome Foundation Limited | 9-(3-(3,5-cis-dimethylpiperazino)propyl)-carbazole, its preparation and pharmaceutical compositions containing it |
CH643263A5 (de) * | 1979-05-11 | 1984-05-30 | Sandoz Ag | Benzodiazepine, ihre herstellung und verwendung. |
HU178523B (en) * | 1979-05-18 | 1982-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing new pyrazolo-quinazoline derivatives |
US4230707A (en) * | 1979-08-27 | 1980-10-28 | Warner-Lambert Company | Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production |
US4358456A (en) * | 1980-05-03 | 1982-11-09 | John Wyeth & Brother Limited | Antipsychotic piperidinomethyl-indole derivatives |
US4396770A (en) * | 1982-04-09 | 1983-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
US4415581A (en) * | 1982-04-09 | 1983-11-15 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines to treat psychoses |
US4409230A (en) * | 1982-04-09 | 1983-10-11 | Hoechst-Roussel Pharmaceuticals Inc. | Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof |
US4374245A (en) * | 1982-04-09 | 1983-02-15 | Hoechst-Roussel Pharmaceuticals Inc. | 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
US4390544A (en) * | 1982-04-09 | 1983-06-28 | Hoechst-Roussel Pharmaceuticals Inc. | {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
-
1982
- 1982-05-24 US US06/381,484 patent/US4469868A/en not_active Expired - Fee Related
-
1983
- 1983-04-11 IE IE822/83A patent/IE55111B1/en unknown
- 1983-04-12 AU AU13427/83A patent/AU553708B2/en not_active Ceased
- 1983-04-12 IL IL68360A patent/IL68360A/xx unknown
- 1983-04-14 ZA ZA832637A patent/ZA832637B/xx unknown
- 1983-04-19 CA CA000426194A patent/CA1210393A/en not_active Expired
- 1983-05-13 EP EP83302715A patent/EP0095289B1/en not_active Expired
- 1983-05-13 DE DE8383302715T patent/DE3368635D1/de not_active Expired
- 1983-05-13 AT AT83302715T patent/ATE24510T1/de not_active IP Right Cessation
- 1983-05-18 PH PH28929A patent/PH18454A/en unknown
- 1983-05-18 FI FI831742A patent/FI74012C/fi not_active IP Right Cessation
- 1983-05-20 DK DK227183A patent/DK161968C/da not_active IP Right Cessation
- 1983-05-20 NO NO831792A patent/NO160444C/no unknown
- 1983-05-23 HU HU831811A patent/HU187913B/hu not_active IP Right Cessation
- 1983-05-23 GR GR71429A patent/GR79262B/el unknown
- 1983-05-23 KR KR1019830002255A patent/KR870000931B1/ko not_active IP Right Cessation
- 1983-05-23 NZ NZ204321A patent/NZ204321A/en unknown
- 1983-05-23 PT PT76745A patent/PT76745B/pt unknown
- 1983-05-23 ES ES522617A patent/ES8407051A1/es not_active Expired
- 1983-05-24 JP JP58090133A patent/JPS58210087A/ja active Granted
-
1984
- 1984-02-01 ES ES529373A patent/ES529373A0/es active Granted
- 1984-02-01 ES ES529371A patent/ES8506315A1/es not_active Expired
- 1984-02-01 ES ES529372A patent/ES8506019A1/es not_active Expired
-
1985
- 1985-06-26 AR AR300815A patent/AR240941A1/es active
-
1989
- 1989-12-28 HK HK1029/89A patent/HK102989A/xx unknown
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