AR124019A1 - Construcciones polipeptídicas que se unen a cd3 - Google Patents

Construcciones polipeptídicas que se unen a cd3

Info

Publication number
AR124019A1
AR124019A1 ARP210103091A ARP210103091A AR124019A1 AR 124019 A1 AR124019 A1 AR 124019A1 AR P210103091 A ARP210103091 A AR P210103091A AR P210103091 A ARP210103091 A AR P210103091A AR 124019 A1 AR124019 A1 AR 124019A1
Authority
AR
Argentina
Prior art keywords
polypeptide
cdr
sequence
region
polypeptide construct
Prior art date
Application number
ARP210103091A
Other languages
English (en)
Inventor
Doris Rau
Tobias Raum
Patrick Hoffmann
Markus Muenz
Matthias Klinger
Virginie Naegele
Lisa Winkel
Pavan Ghattyvenkatakrishna
Joon Hoi Huh
Arnold Mauley
Sekhar Kanapuram
Original Assignee
Amgen Res Munich Gmbh
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh, Amgen Inc filed Critical Amgen Res Munich Gmbh
Publication of AR124019A1 publication Critical patent/AR124019A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a un polipéptido o construcción polipeptídica que comprende: un dominio de unión que se une a un epítopo extracelular de la cadena CD3e humana que comprende o que consiste en una región VH y una región VL, donde i) la región VH comprende: una secuencia de CDR-H1 de X¹YAX²N, donde X¹ es K, V, S, G, R, T o I; y X² es M o I; una secuencia de CDR-H2 de RIRSKYNNYATYYADX¹VKX², donde X¹ es S o Q; y X² es D, G, K, S o E; y una secuencia de CDR-H3 de HX¹NFGNSYX²SX³X⁴AY, donde X¹ es G, R o A; X² es I, L, V o T; X³ es Y, W o F; y X⁴ es W, F o Y; y ii) donde la región VL comprende: una secuencia CDR-L1 de X¹SSTGAVTX²X³X⁴YX⁵N, donde X¹ es G, R o A; X² es S o T; X³ es G o S; X⁴ es N o Y; y X⁵ es P o A; la secuencia CDR-L2 de X¹TX²X³X⁴X⁵X⁶; donde X¹ es G o A; X² es K, D o N; X³ es F, M o K; X⁴ es L o R; X⁵ es A, P o V; y X⁶ es P o S; y una secuencia CDR-L3 de X¹LWYSNX²WV, donde X¹ es V, A o T; y X² es R o L; y iii) donde una o más de las secuencias de CDR de la región VH de i) y/o de la región VL de ii) comprenden una sustitución de aminoácidos o una combinación de los mismos seleccionada de X²4V y X²4F en CDR-H1; D15 y X¹16A en CDR-H2; H1, X¹2E, F4 y N6 en CDR-H3; y X¹1L y W3 en CDRL3. La invención también se refiere a un polinucleótido que codifica el polipéptido o construcción polipeptídica de la invención, un vector que comprende dicho polinucleótido y una célula huésped transformada o transfectada con dicho polinucleótido o con dicho vector. Además, la invención también proporciona un procedimiento para la producción de dicho polipéptido o construcción polipeptídica y una composición farmacéutica que comprende dicho polipéptido o construcción polipeptídica de la invención. Además, la invención se refiere a usos médicos de dicho polipéptido o construcción polipeptídica y kits que comprenden dicho polipéptido o construcción polipeptídica.
ARP210103091A 2020-11-06 2021-11-08 Construcciones polipeptídicas que se unen a cd3 AR124019A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063110545P 2020-11-06 2020-11-06

Publications (1)

Publication Number Publication Date
AR124019A1 true AR124019A1 (es) 2023-02-01

Family

ID=78819446

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103091A AR124019A1 (es) 2020-11-06 2021-11-08 Construcciones polipeptídicas que se unen a cd3

Country Status (14)

Country Link
US (1) US20230406929A1 (es)
EP (1) EP4240767A1 (es)
JP (1) JP2023547661A (es)
KR (1) KR20230104229A (es)
CN (1) CN116635421A (es)
AR (1) AR124019A1 (es)
AU (1) AU2021375733A1 (es)
BR (1) BR112023008670A2 (es)
CA (1) CA3199931A1 (es)
CL (1) CL2023001269A1 (es)
IL (1) IL302597A (es)
MX (1) MX2023005323A (es)
TW (1) TW202225188A (es)
WO (1) WO2022096698A1 (es)

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