AR108202A1 - Reducción de la carga tumoral minimal mediante la administración de antagonistas de ccr1 en combinación con inhibidores de pd-1 o inhibidores pd-l1 - Google Patents
Reducción de la carga tumoral minimal mediante la administración de antagonistas de ccr1 en combinación con inhibidores de pd-1 o inhibidores pd-l1Info
- Publication number
- AR108202A1 AR108202A1 ARP170100898A ARP170100898A AR108202A1 AR 108202 A1 AR108202 A1 AR 108202A1 AR P170100898 A ARP170100898 A AR P170100898A AR P170100898 A ARP170100898 A AR P170100898A AR 108202 A1 AR108202 A1 AR 108202A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitors
- inhibitor
- ccr1
- administration
- effective amount
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 title abstract 4
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 title abstract 4
- 239000012270 PD-1 inhibitor Substances 0.000 title abstract 3
- 239000012668 PD-1-inhibitor Substances 0.000 title abstract 3
- 229940121655 pd-1 inhibitor Drugs 0.000 title abstract 3
- 239000012271 PD-L1 inhibitor Substances 0.000 title abstract 2
- 229940121656 pd-l1 inhibitor Drugs 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 229940122444 Chemokine receptor antagonist Drugs 0.000 abstract 3
- 239000002559 chemokine receptor antagonist Substances 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010061309 Neoplasm progression Diseases 0.000 abstract 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000005751 tumor progression Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente solicitud proporciona métodos para reducir la carga tumoral minimal, el crecimiento tumoral, el avance tumoral y/o la metástasis en un sujeto que padece un cáncer de tumor sólido como por ejemplo el cáncer de mama triple negativo. Los métodos incluyen la administración a un sujeto que lo necesite de una cantidad eficaz terapéuticamente de un inhibidor de PD-L1 o un inhibidor de PD-1 en combinación con un antagonista del receptor de quimiocinas de molécula pequeña que bloquea CCR1. Reivindicación 4: El método de cualquiera de las reivindicaciones 1 a 3, en donde el antagonista del receptor de quimiocina CCR1 tiene la fórmula (1), en donde cada A es N o CH y como mínimo una A es N; R¹ es halógeno; R³ es seleccionado del grupo que consiste en C₁₋₈ alquilo, C₃₋₈ cicloalquilo y C₂₋₈ alquenilo; y R⁸ es C₁₋₈ alquilo; o una sal del mismo aceptable farmacéuticamente. Reivindicación 25: Un equipo para el tratamiento de un sujeto que tiene un cáncer de tumor sólido, dicho equipo comprende una cantidad eficaz terapéuticamente de un antagonista del receptor de quimiocina CCR1 y una cantidad eficaz terapéuticamente de un inhibidor de PD-1 o un inhibidor de PD-L1, con instrucciones para una administración eficaz.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319689P | 2016-04-07 | 2016-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108202A1 true AR108202A1 (es) | 2018-07-25 |
Family
ID=59999231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100898A AR108202A1 (es) | 2016-04-07 | 2017-04-07 | Reducción de la carga tumoral minimal mediante la administración de antagonistas de ccr1 en combinación con inhibidores de pd-1 o inhibidores pd-l1 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10568870B2 (es) |
| EP (1) | EP3439653B1 (es) |
| JP (1) | JP2022130424A (es) |
| KR (1) | KR102370704B1 (es) |
| CN (1) | CN109310677A (es) |
| AR (1) | AR108202A1 (es) |
| AU (1) | AU2017246460B2 (es) |
| BR (1) | BR112018070361A2 (es) |
| CA (1) | CA3019391A1 (es) |
| DK (1) | DK3439653T3 (es) |
| ES (1) | ES2864148T3 (es) |
| IL (1) | IL261998B2 (es) |
| MX (1) | MX2018012132A (es) |
| PL (1) | PL3439653T3 (es) |
| PT (1) | PT3439653T (es) |
| RU (1) | RU2745195C2 (es) |
| SG (1) | SG11201808626WA (es) |
| TW (1) | TWI808938B (es) |
| WO (1) | WO2017176965A1 (es) |
| ZA (1) | ZA201806633B (es) |
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| CA2978942A1 (en) | 2015-03-13 | 2016-09-22 | Cytomx Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| MX2018000621A (es) | 2015-07-13 | 2018-05-11 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos. |
| KR102370704B1 (ko) | 2016-04-07 | 2022-03-03 | 케모센트릭스, 인크. | Pd-1 억제제 또는 pd-l1 억제제와 조합하여 ccr1 길항제를 투여하여 종양 총량을 감소시키는 방법 |
| CN109803651B (zh) | 2016-06-27 | 2022-05-31 | 凯莫森特里克斯股份有限公司 | 免疫调节剂化合物 |
| EP3616720B1 (en) * | 2017-03-29 | 2021-02-17 | Shionogi&Co., Ltd. | Pharmaceutical composition for cancer treatment |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| US10919852B2 (en) | 2017-07-28 | 2021-02-16 | Chemocentryx, Inc. | Immunomodulator compounds |
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-
2017
- 2017-04-06 KR KR1020187032233A patent/KR102370704B1/ko active IP Right Grant
- 2017-04-06 US US15/480,992 patent/US10568870B2/en active Active
- 2017-04-06 BR BR112018070361A patent/BR112018070361A2/pt not_active Application Discontinuation
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- 2017-04-06 WO PCT/US2017/026290 patent/WO2017176965A1/en active Application Filing
- 2017-04-06 PL PL17779801T patent/PL3439653T3/pl unknown
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| EP3439653B1 (en) | 2021-01-20 |
| CN109310677A (zh) | 2019-02-05 |
| AU2017246460B2 (en) | 2021-04-22 |
| SG11201808626WA (en) | 2018-10-30 |
| US20170290808A1 (en) | 2017-10-12 |
| ZA201806633B (en) | 2021-04-28 |
| IL261998B (en) | 2022-11-01 |
| US11744822B2 (en) | 2023-09-05 |
| IL261998B2 (en) | 2023-03-01 |
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| EP3439653A4 (en) | 2019-12-04 |
| US20200289472A1 (en) | 2020-09-17 |
| RU2745195C2 (ru) | 2021-03-22 |
| ES2864148T3 (es) | 2021-10-13 |
| TW201801724A (zh) | 2018-01-16 |
| KR20190020291A (ko) | 2019-02-28 |
| TWI808938B (zh) | 2023-07-21 |
| DK3439653T3 (da) | 2021-03-29 |
| PL3439653T3 (pl) | 2021-07-05 |
| KR102370704B1 (ko) | 2022-03-03 |
| US10568870B2 (en) | 2020-02-25 |
| WO2017176965A1 (en) | 2017-10-12 |
| RU2018138828A (ru) | 2020-05-15 |
| IL261998A (en) | 2018-10-31 |
| CA3019391A1 (en) | 2017-10-12 |
| MX2018012132A (es) | 2019-03-28 |
| PT3439653T (pt) | 2021-03-25 |
| EP3439653A1 (en) | 2019-02-13 |
| RU2018138828A3 (es) | 2020-08-12 |
| BR112018070361A2 (pt) | 2019-01-29 |
| JP2019510832A (ja) | 2019-04-18 |
| AU2017246460A1 (en) | 2018-10-25 |
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