AR108034A1 - Moléculas de unión a ror1, y métodos de uso de las mismas - Google Patents
Moléculas de unión a ror1, y métodos de uso de las mismasInfo
- Publication number
- AR108034A1 AR108034A1 ARP170100381A ARP170100381A AR108034A1 AR 108034 A1 AR108034 A1 AR 108034A1 AR P170100381 A ARP170100381 A AR P170100381A AR P170100381 A ARP170100381 A AR P170100381A AR 108034 A1 AR108034 A1 AR 108034A1
- Authority
- AR
- Argentina
- Prior art keywords
- ror1
- absent
- binding
- molecule
- binding molecules
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente se relaciona con moléculas de unión a ROR1 optimizadas que comprenden Dominios Variables de Cadena Ligera y/o Variables de Cadena Pesada (VH) que se han optimizado para unirse a un epítopo presente en el polipéptido ROR1 de humano a modo de mostrar una afinidad de unión intensificada para ROR1 de humano y/o una inmunogenicidad reducida después de su administración a sujetos receptores. La presente pertenece en particular a moléculas biespecíficas, triespecíficas o multiespecíficas de unión a ROR1, incluyendo diacuerpos biespecíficos, BiTE, anticuerpos biespecíficos, moléculas de unión trivalente, etc., que comprenden: (i) tales Dominios Variables de unión a ROR1 optimizados y (ii) un Dominio capaz de unir un epítopo de una molécula presente en la superficie de una célula efectora. También se dirige a composiciones farmacéuticas que contienen cualquiera de tales moléculas de unión a ROR1, y a métodos que implican el uso de cualquiera de tales moléculas de unión a ROR1 en el tratamiento de cáncer y otras enfermedades y padecimientos. Reivindicación 1: Una molécula de unión a ROR1, caracterizada porque comprende un Dominio Variable de Cadena ligera (VL) y un Dominio Variable de Cadena Pesada (VH), en donde el Dominio VL tiene la secuencia de aminoácidos de SEQ ID Nº 8: en donde X⁶ es W, y en donde: QLVLTQSPSASASLGX¹SVX²LTCTLSSGHKTDTIDWYQQQPGKAPRʸLMX³LEGSGSYNKGSGVPDRFX⁴SGX⁵SSGADX⁶YLTISSLQSEDEADYYCGT DX7PGNYLFGGGTQLTVLG (a) X¹ es S o G, X² es K, I o N, X³ es K o N, X⁴ es G o se encuentra ausente, X⁵ es S o I, X⁷ es Y o N; (b) X¹ es S, X² es K, X³ es K, X⁴ es G o se encuentra ausente, X⁵ es S, y X⁷ es N; (c) X¹ es S, X² es K, X³ es K, X⁴ es G o se encuentra ausente, X⁵ es I, y X⁷ es Y; (d) X¹ es S, X² es K, X³ es K, X⁴ es G o se encuentra ausente, X⁵ es I, y X⁷ es N; o (e) X¹ es S, X² es K, X³ es K, X⁴ es G o se encuentra ausente, X⁵ es S, y X⁷ es Y. Reivindicación 5: La molécula de unión a ROR1 de conformidad con cualquiera de las reivindicaciones 1 - 3, caracterizada porque la molécula es: (a) un anticuerpo biespecífico; o (b) un diacuerpo, el diacuerpo siendo un complejo enlazado de forma covalente que comprende dos, tres, cuatro o cinco cadenas de polipéptidos; o (c) una molécula de unión trivalente, la molécula de unión trivalente siendo un complejo enlazado de forma covalente que comprende tres, cuatro, cinco o más cadenas de polipéptidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296267P | 2016-02-17 | 2016-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108034A1 true AR108034A1 (es) | 2018-07-11 |
Family
ID=58191624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100381A AR108034A1 (es) | 2016-02-17 | 2017-02-15 | Moléculas de unión a ror1, y métodos de uso de las mismas |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170233472A1 (es) |
| AR (1) | AR108034A1 (es) |
| TW (1) | TW201730212A (es) |
| UY (1) | UY37127A (es) |
| WO (1) | WO2017142928A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017072361A1 (en) | 2015-10-30 | 2017-05-04 | Nbe-Therapeutics Ag | Anti-ror1 antibodies |
| EP3405496B1 (en) | 2016-01-20 | 2023-10-25 | University of Florida Research Foundation, Incorporated | Ror1 antibody compositions and related methods |
| AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| KR20190120782A (ko) | 2017-02-20 | 2019-10-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
| EP3630183A4 (en) * | 2017-05-23 | 2021-03-03 | Dragonfly Therapeutics, Inc. | PROTEIN THAT BINDING NKG2D, CD16 AND ROR1 OR ROR2 |
| GB201710838D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | Bispecific antibodies |
| GB201710835D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| GB201710836D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| EP3655435A1 (en) * | 2017-07-20 | 2020-05-27 | NBE-Therapeutics AG | Multispecific antibody product that binds to different ror1 epitopes |
| SG11202000846WA (en) | 2017-08-07 | 2020-02-27 | Nbe Therapeutics Ag | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| CN117756946A (zh) * | 2017-11-03 | 2024-03-26 | 莱蒂恩技术公司 | 用于用抗ror1免疫治疗来治疗癌症的组合物和方法 |
| US20200362054A1 (en) * | 2017-11-21 | 2020-11-19 | Brian Granda | Trispecific binding molecules against tumor-associated antigents and use thereof |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| AU2019218136A1 (en) | 2018-02-08 | 2020-08-13 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| AU2018414456A1 (en) * | 2018-03-22 | 2020-10-15 | Universität Stuttgart | Multivalent binding molecules |
| WO2019225777A1 (ko) * | 2018-05-23 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-ror1 항체 및 그 용도 |
| KR20230146098A (ko) | 2018-05-23 | 2023-10-18 | 화이자 인코포레이티드 | GUCY2c에 특이적인 항체 및 이의 용도 |
| WO2020237173A1 (en) | 2019-05-23 | 2020-11-26 | VelosBio Inc. | Anti-ror1/anti-cd3 bispecific binding molecules |
| US20240010721A1 (en) * | 2020-09-03 | 2024-01-11 | Harbour Biomed (Shanghai) Co., Ltd | Ror1-targeting antibody or antigen-binding fragment thereof, preparation method therefor, and application thereof |
| EP3988568A1 (en) | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
| EP4288451A1 (en) | 2021-02-02 | 2023-12-13 | Numab Therapeutics AG | Multispecific antibodies having specificity for ror1 and cd3 |
| CN114539411B (zh) * | 2022-04-29 | 2022-11-11 | 山东博安生物技术股份有限公司 | 一种ror1抗体或其抗原结合片段 |
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| CA2863944A1 (en) | 2012-02-10 | 2013-08-15 | Research Corporation Technologies, Inc. | Fusion proteins comprising immunoglobulin constant domain-derived scaffolds |
| WO2013163427A1 (en) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
| KR20150013188A (ko) | 2012-05-24 | 2015-02-04 | 에프. 호프만-라 로슈 아게 | 다중특이적 항체 |
| WO2014022540A1 (en) | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Multivalent antigen-binding proteins |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| EP2789630A1 (en) * | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| UA116479C2 (uk) * | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
| EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
| TWI707872B (zh) | 2014-05-29 | 2020-10-21 | 美商宏觀基因股份有限公司 | 特異性結合多種癌症抗原的三特異性結合分子和其使用方法 |
| AU2015295349B2 (en) * | 2014-07-29 | 2020-09-24 | Cellectis | ROR1(NTRKR1)specific chimeric antigen receptors for cancer immunotherapy |
| WO2016094873A2 (en) * | 2014-12-12 | 2016-06-16 | Emergent Product Development Seattle, Llc | Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods |
-
2017
- 2017-02-15 WO PCT/US2017/017939 patent/WO2017142928A1/en active Application Filing
- 2017-02-15 TW TW106104961A patent/TW201730212A/zh unknown
- 2017-02-15 UY UY0001037127A patent/UY37127A/es unknown
- 2017-02-15 US US15/433,534 patent/US20170233472A1/en not_active Abandoned
- 2017-02-15 AR ARP170100381A patent/AR108034A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017142928A1 (en) | 2017-08-24 |
| TW201730212A (zh) | 2017-09-01 |
| US20170233472A1 (en) | 2017-08-17 |
| UY37127A (es) | 2017-08-31 |
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