AR108010A1 - Derivados de indolina y su uso como inhibidores de ews-fli1 - Google Patents

Derivados de indolina y su uso como inhibidores de ews-fli1

Info

Publication number
AR108010A1
AR108010A1 ARP170100787A ARP170100787A AR108010A1 AR 108010 A1 AR108010 A1 AR 108010A1 AR P170100787 A ARP170100787 A AR P170100787A AR P170100787 A ARP170100787 A AR P170100787A AR 108010 A1 AR108010 A1 AR 108010A1
Authority
AR
Argentina
Prior art keywords
alkyl
indolina
fli1
ews
inhibitors
Prior art date
Application number
ARP170100787A
Other languages
English (en)
Inventor
Stephen E Webber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of AR108010A1 publication Critical patent/AR108010A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicación 1: Un compuesto que tiene la fórmula (1), o un estereoisómero, una sal farmacéuticamente aceptable o un solvato del mismo, en la cual A se selecciona del grupo que consiste en -OH, D, H, F, y -NH₂; en la cual R¹, R², R³, y R⁴ se seleccionan independientemente del grupo que consiste en H, Cl, -CN,-CF₃, alquilo C₁₋₆, alcoxi C₁₋₆, -C(=O)NH₂, -NO₂, -NH₂, -OH; y en la cual R⁷, R⁸, R⁹, R¹⁰ y R¹¹ se seleccionan independientemente del grupo que consiste en H, D, F, Cl, halógeno, CN, CF₃, alquilo C₁₋₆, arilo, heteroarilo, -O(arilo), -O(heteroarilo), -CO₂H, -CO₂(alquilo C₁₋₆), -NHSO₂(alquilo C₁₋₆), -NHSO₂(arilo), -NHCONH(alquilo C₁₋₆), -NHCON(alquilo C₁₋₆)₂, -N(alquilo C₁₋₆)CONH₂, -N(alquilo C₁₋₆)CONH(alquilo C₁₋₆), -N(alquilo C₁₋₆)CON(alquilo C₁₋₆)₂, -SO₂(alquilo C₁₋₆), -SO₂NH₂, -SO₂NH(C₁₋₆ alquil), -SO₂N(C₁₋₆ alquil)₂, cicloalquilo C₃₋₈ y heterocicloalquilo C₃₋₈.
ARP170100787A 2016-03-31 2017-03-30 Derivados de indolina y su uso como inhibidores de ews-fli1 AR108010A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662316156P 2016-03-31 2016-03-31
US201662417621P 2016-11-04 2016-11-04

Publications (1)

Publication Number Publication Date
AR108010A1 true AR108010A1 (es) 2018-07-04

Family

ID=59960688

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170100787A AR108010A1 (es) 2016-03-31 2017-03-30 Derivados de indolina y su uso como inhibidores de ews-fli1

Country Status (10)

Country Link
US (3) US9822122B2 (es)
EP (2) EP3436434B1 (es)
JP (2) JP6864379B2 (es)
KR (2) KR102514814B1 (es)
CN (1) CN109219594B (es)
AR (1) AR108010A1 (es)
DK (1) DK3436434T3 (es)
ES (1) ES2823190T3 (es)
TW (2) TWI786723B (es)
WO (1) WO2017172368A1 (es)

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TR202002324A2 (tr) * 2020-02-17 2021-08-23 Bahcesehir Ueniversitesi Yeni̇ mouse double minute 2 (mdm2) i̇nhi̇bi̇törü olarak kullanmak i̇çi̇n drg-mdm2-3
CN111518086B (zh) * 2020-05-22 2021-08-06 广州医科大学 氧化吲哚-萘并呋喃衍生物及其制备方法、用途以及包含其的药物组合物、制剂
WO2023178040A2 (en) * 2022-03-13 2023-09-21 University Of Virginia Patent Foundation Inhibitors of ews-fli1
CN115993455A (zh) * 2022-12-29 2023-04-21 南京医科大学康达学院 Rna结合蛋白nova2作为非小细胞肺癌转移标志物的应用

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CN109219594B (zh) 2022-10-11
US20170349600A1 (en) 2017-12-07
ES2823190T3 (es) 2021-05-06
TWI793070B (zh) 2023-02-21
US10711008B2 (en) 2020-07-14
JP2021102643A (ja) 2021-07-15
US9822122B2 (en) 2017-11-21
EP3436434A1 (en) 2019-02-06
KR20220038529A (ko) 2022-03-28
US10351569B2 (en) 2019-07-16
EP3436434B1 (en) 2020-07-08
KR20180123569A (ko) 2018-11-16
US20170283420A1 (en) 2017-10-05
JP2019510069A (ja) 2019-04-11
KR102514814B1 (ko) 2023-03-27
TW202140492A (zh) 2021-11-01
JP7269668B2 (ja) 2023-05-09
EP3436434A4 (en) 2019-08-28
TW201738209A (zh) 2017-11-01
TWI786723B (zh) 2022-12-11
US20190337951A1 (en) 2019-11-07
WO2017172368A1 (en) 2017-10-05
JP6864379B2 (ja) 2021-04-28
CN109219594A (zh) 2019-01-15
EP3795563A1 (en) 2021-03-24
DK3436434T3 (da) 2020-09-21
KR102375929B1 (ko) 2022-03-16

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