AR106729A1 - 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación - Google Patents

4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Info

Publication number
AR106729A1
AR106729A1 ARP160103515A ARP160103515A AR106729A1 AR 106729 A1 AR106729 A1 AR 106729A1 AR P160103515 A ARP160103515 A AR P160103515A AR P160103515 A ARP160103515 A AR P160103515A AR 106729 A1 AR106729 A1 AR 106729A1
Authority
AR
Argentina
Prior art keywords
oxoetil
difluorofenil
piridin
oxi
benzonitrile
Prior art date
Application number
ARP160103515A
Other languages
English (en)
Inventor
Whiteker Gregory
Ryan Sarah
Hao Yan
Yang Qiang
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of AR106729A1 publication Critical patent/AR106729A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un método para preparar un compuesto de fórmula (1) que comprende el paso de poner en contacto un compuesto de fórmula (2) con una mezcla formada combinando 1-bromo-2,4-difluorobenceno con un reactivo metálico u organometálico, y un ácido.
ARP160103515A 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación AR106729A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562256399P 2015-11-17 2015-11-17

Publications (1)

Publication Number Publication Date
AR106729A1 true AR106729A1 (es) 2018-02-14

Family

ID=58717794

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103515A AR106729A1 (es) 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Country Status (12)

Country Link
US (1) US20180327359A1 (es)
EP (1) EP3376866A4 (es)
JP (1) JP6987070B2 (es)
KR (1) KR20180101343A (es)
CN (1) CN108882709A (es)
AR (1) AR106729A1 (es)
BR (1) BR112018009924A2 (es)
CA (1) CA3005744A1 (es)
IL (1) IL259400B (es)
TW (1) TWI636045B (es)
WO (1) WO2017087597A1 (es)
ZA (1) ZA201803748B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX371291B (es) 2014-03-19 2020-01-24 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion.
CA2942932A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10000465B2 (en) 2014-03-19 2018-06-19 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942982C (en) 2014-03-19 2023-09-19 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
CA2942976C (en) 2014-03-19 2022-05-10 Viamet Pharmaceuticals, Inc. Antifungal compound process
CN109970629B (zh) 2014-03-19 2023-04-11 迈科维亚医药公司 抗真菌化合物的制备方法
AU2015231208B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EA037521B1 (ru) 2015-09-18 2021-04-07 ВиПиЭс-3, ИНК. Противогрибковые соединения и способы их получения
SG11201810655QA (en) 2016-06-20 2019-01-30 Shionogi & Co Method for producing substituted polycyclic pyridone derivative and crystal of same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030029878A (ko) * 2000-08-30 2003-04-16 다우 아그로사이언시즈 엘엘씨 살충제로서 유용한 화합물, 살비제로서 유용한 화합물 및,이들의 사용방법 및 제조방법
CN101094847B (zh) * 2004-11-02 2011-06-15 Msdk.K.公司 芳氧基取代的苯并咪唑衍生物
AU2006267338B2 (en) * 2005-07-13 2012-08-16 Msd K.K. Heterocycle-substituted benzimidazole derivative
US7799820B2 (en) * 2005-09-30 2010-09-21 Banyu Pharmaceutical Co., Ltd. 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions
WO2012177635A1 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2012177603A2 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CA2838916C (en) * 2011-06-23 2020-08-11 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2014043376A1 (en) * 2012-09-12 2014-03-20 Dow Agrosciences Llc Metalloenzyme inhibitor compounds
CA2913914C (en) * 2013-05-28 2018-03-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
CA2942982C (en) * 2014-03-19 2023-09-19 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
CA2942976C (en) * 2014-03-19 2022-05-10 Viamet Pharmaceuticals, Inc. Antifungal compound process
MX2017014848A (es) * 2015-05-18 2018-04-20 Viamet Pharmaceuticals Nc Inc Compuestos antifungicos.

Also Published As

Publication number Publication date
EP3376866A4 (en) 2019-04-10
JP2018535262A (ja) 2018-11-29
IL259400B (en) 2021-06-30
KR20180101343A (ko) 2018-09-12
WO2017087597A1 (en) 2017-05-26
CA3005744A1 (en) 2017-05-26
JP6987070B2 (ja) 2021-12-22
BR112018009924A2 (pt) 2018-11-13
TWI636045B (zh) 2018-09-21
IL259400A (en) 2018-07-31
CN108882709A (zh) 2018-11-23
EP3376866A1 (en) 2018-09-26
ZA201803748B (en) 2019-03-27
TW201726620A (zh) 2017-08-01
US20180327359A1 (en) 2018-11-15

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