AR105327A1 - Derivados de imidazol - Google Patents
Derivados de imidazolInfo
- Publication number
- AR105327A1 AR105327A1 ARP160102101A ARP160102101A AR105327A1 AR 105327 A1 AR105327 A1 AR 105327A1 AR P160102101 A ARP160102101 A AR P160102101A AR P160102101 A ARP160102101 A AR P160102101A AR 105327 A1 AR105327 A1 AR 105327A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- cyclopropyl
- cyano
- isopropyl
- ethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente está relacionada con compuestos de fórmula (1) en el que R¹ es CH₃; R¹ es metilo, etilo, CF₃, CH₂OH, ciclopropilo o ciano, o R¹ y R¹ pueden formar juntos un anillo 1,1-dioxo-tetrahidro-tiofen-3-ilo; R² es hidrógeno, metilo, etilo, isopropilo, terc-butilo, ciclopropilo, hidroximetilo, o 2-propil-2-ol; R³ es Cl, F, CF₃, metilo, metoxi, isopropilo, ciano o ciclopropilo; R⁴ es hidrógeno, metilo, F o Cl; o una sal farmacéuticamente aceptable o sal de adición ácida, una mezcla racémica, o su correspondiente enantiómero y/o isómero óptico y/o estereoisómero de los mismos. Los compuestos de fórmula (1) pueden utilizarse en el tratamiento de trastornos psiquiátricos como esquizofrenia, trastorno bipolar, trastorno obsesivo compulsivo o trastorno del espectro autista.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15176652 | 2015-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR105327A1 true AR105327A1 (es) | 2017-09-27 |
Family
ID=53757994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160102101A AR105327A1 (es) | 2015-07-14 | 2016-07-12 | Derivados de imidazol |
Country Status (8)
Country | Link |
---|---|
US (1) | US10092546B2 (es) |
EP (1) | EP3322699B1 (es) |
JP (1) | JP6846363B2 (es) |
CN (1) | CN107709311B (es) |
AR (1) | AR105327A1 (es) |
HK (1) | HK1250028A1 (es) |
TW (1) | TW201713639A (es) |
WO (1) | WO2017009274A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6518789B2 (ja) | 2015-04-23 | 2019-05-22 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 精神障害の処置において使用するためのテトラゾール誘導体 |
EP3322699B1 (en) * | 2015-07-14 | 2019-05-15 | H. Hoffnabb-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
WO2017133990A1 (en) * | 2016-02-02 | 2017-08-10 | F. Hoffmann-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
JP7068277B2 (ja) | 2016-10-14 | 2022-05-16 | エフ.ホフマン-ラ ロシュ アーゲー | Eaat3阻害剤としてのイミダゾール化合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
CA2658362A1 (en) * | 2006-06-29 | 2008-01-03 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors |
JP2011530483A (ja) * | 2008-08-12 | 2011-12-22 | 武田薬品工業株式会社 | アミド化合物 |
WO2010033168A2 (en) * | 2008-09-18 | 2010-03-25 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
WO2010051188A1 (en) * | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
WO2014078377A1 (en) * | 2012-11-14 | 2014-05-22 | Agenebio, Inc. | Methods and compositions for treating schizophrenia |
EP3322699B1 (en) * | 2015-07-14 | 2019-05-15 | H. Hoffnabb-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
-
2016
- 2016-07-11 EP EP16736493.4A patent/EP3322699B1/en not_active Not-in-force
- 2016-07-11 JP JP2017566096A patent/JP6846363B2/ja active Active
- 2016-07-11 CN CN201680037743.3A patent/CN107709311B/zh not_active Expired - Fee Related
- 2016-07-11 WO PCT/EP2016/066388 patent/WO2017009274A1/en active Application Filing
- 2016-07-12 AR ARP160102101A patent/AR105327A1/es unknown
- 2016-07-13 TW TW105122106A patent/TW201713639A/zh unknown
-
2018
- 2018-01-09 US US15/866,444 patent/US10092546B2/en not_active Expired - Fee Related
- 2018-07-20 HK HK18109421.0A patent/HK1250028A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3322699A1 (en) | 2018-05-23 |
HK1250028A1 (zh) | 2018-11-23 |
EP3322699B1 (en) | 2019-05-15 |
JP2018520135A (ja) | 2018-07-26 |
US20180125823A1 (en) | 2018-05-10 |
CN107709311A (zh) | 2018-02-16 |
TW201713639A (zh) | 2017-04-16 |
WO2017009274A1 (en) | 2017-01-19 |
US10092546B2 (en) | 2018-10-09 |
JP6846363B2 (ja) | 2021-03-24 |
CN107709311B (zh) | 2020-09-25 |
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