AR099698A1 - Anticuerpos contra el c5 que tienen farmacocinética mejorada - Google Patents

Anticuerpos contra el c5 que tienen farmacocinética mejorada

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Publication number
AR099698A1
AR099698A1 ARP150100697A ARP150100697A AR099698A1 AR 099698 A1 AR099698 A1 AR 099698A1 AR P150100697 A ARP150100697 A AR P150100697A AR P150100697 A ARP150100697 A AR P150100697A AR 099698 A1 AR099698 A1 AR 099698A1
Authority
AR
Argentina
Prior art keywords
amino acid
acid sequence
sequence depicted
sec
binding fragment
Prior art date
Application number
ARP150100697A
Other languages
English (en)
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of AR099698A1 publication Critical patent/AR099698A1/es

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Abstract

Reivindicación 1: Un anticuerpo aislado, o fragmento de unión al antígeno de este caracterizado porque: (a) se une a un C5 humano de componente de complemento; (b) inhibe la descomposición del C5 en los fragmentos C5a y C5b; y (c) comprende: (i) una cadena pesada CDR1 que comprende la secuencia de aminoácidos representada en la ID de SEC. nº 23, (ii) una cadena pesada CDR2 que comprende la secuencia de aminoácidos representada en la ID. de SEC. nº 19, (iii) una cadena pesada CDR3 que comprende la secuencia de aminoácidos representada en la ID. de SEC. nº 3, (iv) una cadena liviana CDR1 que comprende la secuencia de aminoácidos representada en la ID. de SEC. nº 4, (v) una cadena liviana CDR2 que comprende la secuencia de aminoácidos representada en la ID. de SEC. nº 5 y (vi) una cadena liviana CDR3 que comprende la secuencia de aminoácidos representada en la ID. de SEC. nº 6. Reivindicación 11: Un ácido nucleico caracterizado porque codifica polipéptido de cadena pesada del anticuerpo o un fragmento de unión al antígeno de este de acuerdo con la reivindicación 6. Reivindicación 18: Una composición farmacéutica caracterizada porque comprende un vehículo farmacéuticamente aceptable y el anticuerpo o un fragmento de unión al antígeno de este de acuerdo con cualquiera de las reivindicaciones 1 a 10. Reivindicación 21: Un artículo de fabricación que comprende: un recipiente que comprende una etiqueta; y una composición caracterizada porque que comprende: (i) anticuerpo aislado o un fragmento de unión al antígeno de este de acuerdo con cualquiera de las reivindicaciones 1 a 10, en donde la etiqueta indica que la composición debe administrarse a un humano que tenga, o se sospeche que tenga, o esté en riesgo de desarrollar, una condición asociada con el complemento. Reivindicación 22: Un método para el tratamiento de un paciente afectado con una condición asociada al complemento, caracterizado porque comprende la administración al sujeto del anticuerpo o un fragmento de unión al antígeno de este de acuerdo con cualquiera de las reivindicaciones 1 a 10 con una cantidad efectiva para tratar la condición asociada al complemento.
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