CO2018005315A2 - Moduladores de la interacción de sestrina-gator2 y sus usos - Google Patents

Moduladores de la interacción de sestrina-gator2 y sus usos

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Publication number
CO2018005315A2
CO2018005315A2 CONC2018/0005315A CO2018005315A CO2018005315A2 CO 2018005315 A2 CO2018005315 A2 CO 2018005315A2 CO 2018005315 A CO2018005315 A CO 2018005315A CO 2018005315 A2 CO2018005315 A2 CO 2018005315A2
Authority
CO
Colombia
Prior art keywords
sestrina
gator2
interaction
compounds
modulators
Prior art date
Application number
CONC2018/0005315A
Other languages
English (en)
Inventor
Eddine Saiah
Kristina Michelle Fetalvero
Sridhar Narayan
David John O'neill
Shomit Sengupta
Original Assignee
Navitor Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Navitor Pharm Inc filed Critical Navitor Pharm Inc
Publication of CO2018005315A2 publication Critical patent/CO2018005315A2/es

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    • C07F7/02—Silicon compounds
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
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Abstract

La presente invención se relaciona con compuestos y métodos útiles para modular la interacción de Sestrina-GATOR2 modulando selectivamente de forma indirecta la actividad de mTORC1. Los compuestos tienen la formula general I. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden compuestos de la presentes invención y métodos para utilizar dichas composiciones en el tratamiento de diversos trastornos.
CONC2018/0005315A 2015-10-23 2018-05-21 Moduladores de la interacción de sestrina-gator2 y sus usos CO2018005315A2 (es)

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