AR090822A1 - Composiciones de cultivo de celulas y metodos para la produccion de polipeptidos - Google Patents
Composiciones de cultivo de celulas y metodos para la produccion de polipeptidosInfo
- Publication number
- AR090822A1 AR090822A1 ARP130101367A AR090822A1 AR 090822 A1 AR090822 A1 AR 090822A1 AR P130101367 A ARP130101367 A AR P130101367A AR 090822 A1 AR090822 A1 AR 090822A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptides
- compositions
- production
- methods
- cell culture
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000006143 cell culture medium Substances 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- 229930003471 Vitamin B2 Natural products 0.000 abstract 1
- 229930003761 Vitamin B9 Natural products 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 229960002477 riboflavin Drugs 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 235000019164 vitamin B2 Nutrition 0.000 abstract 1
- 239000011716 vitamin B2 Substances 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 235000019159 vitamin B9 Nutrition 0.000 abstract 1
- 239000011727 vitamin B9 Substances 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proveen medios de cultivo de células, tal como medios de cultivo de células definidos químicamente, así como métodos de uso de los medios para el crecimiento celular (es decir, cultivo de células) y producción de polipéptidos (por ejemplo, anticuerpos). También se proveen composiciones que comprenden los polipéptidos producidos. Polipéptido. Kit. Reivindicación 1: Un método de cultivo de células, que comprende la etapa de poner en contacto las células con un medio de cultivo celular que comprende: de aproximadamente 200 mg/L a aproximadamente 1200 mg/L de cisteina; de aproximadamente 0,05 mg/L a aproximadamente 1,0 mg/L de vitamina B2; de aproximadamente 0,05 mg/L a aproximadamente 10,0 mg/L de vitamina B6; de aproximadamente 0,05 mg/L a aproximadamente 12,0 mg/L de vitamina B9; y de aproximadamente 0,05 mg/L a aproximadamente 2,5 mg/L de vitamina B12.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261637778P | 2012-04-24 | 2012-04-24 | |
US201261637780P | 2012-04-24 | 2012-04-24 | |
US13/841,864 US20130281355A1 (en) | 2012-04-24 | 2013-03-15 | Cell culture compositions and methods for polypeptide production |
Publications (1)
Publication Number | Publication Date |
---|---|
AR090822A1 true AR090822A1 (es) | 2014-12-10 |
Family
ID=49380652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130101367 AR090822A1 (es) | 2012-04-24 | 2013-04-24 | Composiciones de cultivo de celulas y metodos para la produccion de polipeptidos |
Country Status (22)
Country | Link |
---|---|
US (2) | US20130281355A1 (es) |
EP (2) | EP2841561B1 (es) |
JP (4) | JP6367792B2 (es) |
KR (2) | KR102339106B1 (es) |
CN (2) | CN111440758A (es) |
AR (1) | AR090822A1 (es) |
AU (2) | AU2013251647B2 (es) |
BR (1) | BR112014026308A8 (es) |
CA (1) | CA2871006C (es) |
ES (1) | ES2716301T3 (es) |
HK (1) | HK1208496A1 (es) |
HR (1) | HRP20190484T1 (es) |
IL (1) | IL235235A0 (es) |
MX (2) | MX363493B (es) |
MY (1) | MY181513A (es) |
NZ (1) | NZ701791A (es) |
PL (1) | PL2841561T3 (es) |
RU (2) | RU2678142C2 (es) |
SG (2) | SG10201810830UA (es) |
SI (1) | SI2841561T1 (es) |
WO (1) | WO2013163294A1 (es) |
ZA (2) | ZA201408092B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
BR112015022529A2 (pt) * | 2013-03-15 | 2017-07-18 | Genentech Inc | meios de cultura de células e processos de produção de anticorpo |
PL2970875T3 (pl) * | 2013-03-15 | 2020-08-10 | F.Hoffmann-La Roche Ag | Kompozycje do hodowli komórkowych z przeciwutleniaczami i sposoby wytwarzania polipeptydów |
EP3052640A2 (en) * | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
CN110945593A (zh) * | 2017-06-16 | 2020-03-31 | 通用电气健康护理生物科学股份公司 | 用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法 |
EP3492582A1 (en) | 2017-12-01 | 2019-06-05 | UCB Biopharma SPRL | Cell culture methods |
CN108823267B (zh) * | 2018-06-25 | 2020-05-08 | 深圳市菲鹏生物制药股份有限公司 | 调节cho-k1表达***所分泌抗体的酸性峰含量的方法 |
US20220411795A1 (en) * | 2019-10-31 | 2022-12-29 | William Marsh Rice University | Engineered cells for controlled production |
PE20221790A1 (es) | 2019-12-06 | 2022-11-25 | Regeneron Pharma | Composiciones de proteina anti-vegf y metodos para producir la misma |
MX2022008339A (es) * | 2020-01-31 | 2022-08-04 | Chugai Pharmaceutical Co Ltd | Metodo para producir una composicion que contiene un polipeptido con coloracion suprimida. |
JP7404929B2 (ja) | 2020-02-26 | 2023-12-26 | 富士フイルムビジネスイノベーション株式会社 | 発光装置、光学装置及び計測装置 |
JP7404930B2 (ja) | 2020-02-26 | 2023-12-26 | 富士フイルムビジネスイノベーション株式会社 | 発光装置、光学装置及び計測装置 |
GB202012991D0 (en) | 2020-08-20 | 2020-10-07 | Ucb Biopharma Sprl | Cell culture processes |
US20220251502A1 (en) * | 2020-12-22 | 2022-08-11 | Novartis Ag | Methods for reducing the oxidation level of cysteine residues in a secreted recombinantly-expressed protein during cell culture |
GB202105424D0 (en) | 2021-04-16 | 2021-06-02 | UCB Biopharma SRL | Cell culture processes |
EP4396563A1 (en) | 2021-09-02 | 2024-07-10 | Boehringer Ingelheim International GmbH | Method of determining a future color value or corresponding property and arrangement therefor |
KR102682066B1 (ko) * | 2021-10-12 | 2024-07-05 | 프레스티지바이오로직스 주식회사 | 항체 집단의 제조 방법 |
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2013
- 2013-03-15 US US13/841,864 patent/US20130281355A1/en not_active Abandoned
- 2013-04-24 SG SG10201810830UA patent/SG10201810830UA/en unknown
- 2013-04-24 SI SI201331376T patent/SI2841561T1/sl unknown
- 2013-04-24 KR KR1020207014171A patent/KR102339106B1/ko active IP Right Grant
- 2013-04-24 AU AU2013251647A patent/AU2013251647B2/en active Active
- 2013-04-24 MX MX2014012838A patent/MX363493B/es unknown
- 2013-04-24 JP JP2015509107A patent/JP6367792B2/ja active Active
- 2013-04-24 BR BR112014026308A patent/BR112014026308A8/pt not_active Application Discontinuation
- 2013-04-24 EP EP13720203.2A patent/EP2841561B1/en not_active Revoked
- 2013-04-24 KR KR1020147032389A patent/KR102115052B1/ko active IP Right Grant
- 2013-04-24 WO PCT/US2013/037992 patent/WO2013163294A1/en active Application Filing
- 2013-04-24 CA CA2871006A patent/CA2871006C/en active Active
- 2013-04-24 PL PL13720203T patent/PL2841561T3/pl unknown
- 2013-04-24 NZ NZ701791A patent/NZ701791A/en unknown
- 2013-04-24 EP EP18213796.8A patent/EP3533864A1/en active Pending
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