AR088403A1 - Anticuerpo de union a multiples antigenos estable - Google Patents
Anticuerpo de union a multiples antigenos estableInfo
- Publication number
- AR088403A1 AR088403A1 ARP120103914A ARP120103914A AR088403A1 AR 088403 A1 AR088403 A1 AR 088403A1 AR P120103914 A ARP120103914 A AR P120103914A AR P120103914 A ARP120103914 A AR P120103914A AR 088403 A1 AR088403 A1 AR 088403A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- chain variable
- antibodies
- multiple antigens
- domains
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 108700012920 TNF Proteins 0.000 abstract 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
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- C07K2317/626—Diabody or triabody
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
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Abstract
Proporciona anticuerpos que se unen a múltiples antígenos, teniendo dichos anticuerpos por lo menos dos dominios variables de cadena liviana de anticuerpo y dos dominios variables de cadena pesada de anticuerpo, donde cada dominio variable de cadena liviana está ligado a un dominio variable de cadena pesada para formar una construcción VH/VL, y donde por lo menos uno de los dominios VH comprende un aminoácido en particular en posición AHo 12, 103 y/o 144, y por lo menos uno de los dominios VL comprende un aminoácido en particular en posición AHo 47 y/o 50. También se describen moléculas de ácido nucleico, vectores y células huéspedes para la expresión de los anticuerpos recombinantes, métodos para su aislamiento, y el uso de dichos anticuerpos en medicina. Proporciona un anticuerpo bioespecífico que tiene especificidad para VEGF y TNFa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161549482P | 2011-10-20 | 2011-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR088403A1 true AR088403A1 (es) | 2014-05-28 |
Family
ID=47115743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103914A AR088403A1 (es) | 2011-10-20 | 2012-10-19 | Anticuerpo de union a multiples antigenos estable |
Country Status (15)
Country | Link |
---|---|
US (2) | US20130101586A1 (es) |
EP (2) | EP2768855B1 (es) |
JP (3) | JP2014533239A (es) |
KR (1) | KR20140082700A (es) |
CN (2) | CN103890005A (es) |
AR (1) | AR088403A1 (es) |
AU (1) | AU2012325232B2 (es) |
BR (1) | BR112014009030A2 (es) |
CA (1) | CA2850572A1 (es) |
ES (1) | ES2687245T3 (es) |
MX (1) | MX2014004521A (es) |
RU (2) | RU2652886C2 (es) |
TW (1) | TWI577696B (es) |
UY (1) | UY34404A (es) |
WO (1) | WO2013056851A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
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- 2012-10-19 KR KR1020147009866A patent/KR20140082700A/ko not_active Application Discontinuation
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- 2012-10-19 RU RU2014120154A patent/RU2652886C2/ru not_active IP Right Cessation
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RU2018112861A3 (es) | 2021-08-12 |
WO2013056851A2 (en) | 2013-04-25 |
UY34404A (es) | 2013-05-31 |
TWI577696B (zh) | 2017-04-11 |
BR112014009030A2 (pt) | 2017-09-12 |
AU2012325232B2 (en) | 2017-08-31 |
KR20140082700A (ko) | 2014-07-02 |
JP2019104759A (ja) | 2019-06-27 |
RU2014120154A (ru) | 2015-11-27 |
MX2014004521A (es) | 2014-05-28 |
JP2014533239A (ja) | 2014-12-11 |
CN109608543A (zh) | 2019-04-12 |
CN103890005A (zh) | 2014-06-25 |
JP2017125066A (ja) | 2017-07-20 |
TW201323445A (zh) | 2013-06-16 |
ES2687245T3 (es) | 2018-10-24 |
US20200048336A1 (en) | 2020-02-13 |
CA2850572A1 (en) | 2013-04-25 |
EP2768855A2 (en) | 2014-08-27 |
AU2012325232A8 (en) | 2014-06-26 |
RU2018112861A (ru) | 2019-03-04 |
EP2768855B1 (en) | 2018-06-13 |
EP3431495A1 (en) | 2019-01-23 |
WO2013056851A3 (en) | 2013-06-13 |
RU2652886C2 (ru) | 2018-05-03 |
AU2012325232A1 (en) | 2014-06-05 |
US20130101586A1 (en) | 2013-04-25 |
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