AR083487A1 - Derivados de carbonato de quinuclidina para el tratamiento de tos - Google Patents
Derivados de carbonato de quinuclidina para el tratamiento de tosInfo
- Publication number
- AR083487A1 AR083487A1 ARP110103875A ARP110103875A AR083487A1 AR 083487 A1 AR083487 A1 AR 083487A1 AR P110103875 A ARP110103875 A AR P110103875A AR P110103875 A ARP110103875 A AR P110103875A AR 083487 A1 AR083487 A1 AR 083487A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- heteroaryl
- alkyl
- aryl
- treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Uso de determinados derivados carbonato de quinuclidina como supresores de la tos, en particular para el tratamiento de pacientes con infecciones del tracto respiratorio superior o asma. Composiciones farmacéuticas.Reivindicación 1: Un compuesto, caracterizado porque es de la fórmula general (1) para su uso en el tratamiento de la tos, en donde R1 y R2 son iguales o diferentes y se seleccionan de manera independiente del grupo que consiste de H, cicloalquilo C3-8, arilo y heteroarilo, en donde dicho arilo o heteroarilo puede estar opcionalmente sustituido con un átomo de halógeno o con uno o más sustituyentes seleccionados de manera independiente del grupo que consiste de OH, O-alquilo C1-10, oxo (=O), SH, S-alquilo C1-10, NO2, CN, CONH2, COOH, alcoxicarbonilo C1-10, alquilsulfanilo C1-10, alquilsulfinilo C1-10, alquilsulfonilo C1-10, alquilo C1-10 y alcoxilo C1-10 o cuando ambos R1 y R2 son de manera independiente arilo o heteroarilo pueden estar unidos a través de un grupo Y que puede ser un grupo (CH2)n (donde n = 0, 1 ó 2), en donde cuando n = 0, Y es un enlace simple, que forma un sistema de anillos tricíclico en donde cualquiera de los átomos de carbono de (CH2)n se puede sustituir con un heteroátomo seleccionado entre O, S, N y con la salvedad que R1 y R2 nunca sean ambos H; y X- es un anión farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10188152 | 2010-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083487A1 true AR083487A1 (es) | 2013-02-27 |
Family
ID=43216448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103875A AR083487A1 (es) | 2010-10-20 | 2011-10-19 | Derivados de carbonato de quinuclidina para el tratamiento de tos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120101076A1 (es) |
| EP (1) | EP2630145A1 (es) |
| KR (1) | KR20130140672A (es) |
| CN (1) | CN103168038A (es) |
| AR (1) | AR083487A1 (es) |
| BR (1) | BR112013009138A2 (es) |
| CA (1) | CA2815035A1 (es) |
| RU (1) | RU2013118026A (es) |
| WO (1) | WO2012052297A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2154136A1 (en) | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
| EP2206712A1 (en) | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
| EP2797910B1 (en) | 2011-12-30 | 2015-09-16 | Chiesi Farmaceutici S.p.A. | Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73543C2 (uk) * | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| AU2003222786A1 (en) * | 2002-04-18 | 2003-10-27 | Ucb, S.A. | Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions |
| DE102008005219A1 (de) | 2008-01-18 | 2009-07-23 | Limo Patentverwaltung Gmbh & Co. Kg | Vorrichtung zur Formung eines Lichtstrahls sowie Verfahren zur Herstellung einer derartigen Vorrichtung |
| JP2011527558A (ja) * | 2008-07-07 | 2011-10-27 | パワーバイプロキシ リミテッド | 非接触受電装置およびその動作方法 |
| EP2154136A1 (en) * | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
-
2011
- 2011-10-06 BR BR112013009138A patent/BR112013009138A2/pt not_active IP Right Cessation
- 2011-10-06 WO PCT/EP2011/067431 patent/WO2012052297A1/en active Application Filing
- 2011-10-06 KR KR1020137009476A patent/KR20130140672A/ko not_active Application Discontinuation
- 2011-10-06 RU RU2013118026/04A patent/RU2013118026A/ru not_active Application Discontinuation
- 2011-10-06 EP EP11776386.2A patent/EP2630145A1/en not_active Withdrawn
- 2011-10-06 CA CA2815035A patent/CA2815035A1/en not_active Abandoned
- 2011-10-06 CN CN2011800504012A patent/CN103168038A/zh active Pending
- 2011-10-11 US US13/270,467 patent/US20120101076A1/en not_active Abandoned
- 2011-10-19 AR ARP110103875A patent/AR083487A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012052297A1 (en) | 2012-04-26 |
| EP2630145A1 (en) | 2013-08-28 |
| CA2815035A1 (en) | 2012-04-26 |
| KR20130140672A (ko) | 2013-12-24 |
| US20120101076A1 (en) | 2012-04-26 |
| RU2013118026A (ru) | 2014-10-27 |
| CN103168038A (zh) | 2013-06-19 |
| BR112013009138A2 (pt) | 2016-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |