AR073923A1 - Pirido( 4,3-b) indoles que contienen restos rigidos - Google Patents
Pirido( 4,3-b) indoles que contienen restos rigidosInfo
- Publication number
- AR073923A1 AR073923A1 ARP090104220A ARP090104220A AR073923A1 AR 073923 A1 AR073923 A1 AR 073923A1 AR P090104220 A ARP090104220 A AR P090104220A AR P090104220 A ARP090104220 A AR P090104220A AR 073923 A1 AR073923 A1 AR 073923A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- independently
- halo
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
También se proveen composiciones farmacéuticas que comprenden los compuestos, dado que son métodos de uso de compuestos en una variedad de aplicaciones terapéuticas, incluyendo el tratamiento de un trastorno cognitivo, trastorno psicotico, trastorno mediado por neurotrasmisores y/o un trastorno neuronal. Reivindicacion 1: Un compuesto de la formula (1) o una de sus sales o solvatos, en donde R1 es H, hidroxilo, nitro, ciano, halo, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, perhaloalquilo, acilo, aciloxi, carbonilalcoxi, heterociclilo sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, aralquilo sustituido o no sustituido, perhaloalcoxi C1-8, alcoxi, ariloxi, carboxilo, tiol, tioalquilo, amino sustituido o no sustituido, acilamino, aminoacilo, aminocarbonilamino, aminocarboniloxi, aminosulfonilo, sulfonilamino, sulfonilo o carbonilalquilenalcoxi; cada R2a y R2b es, de modo independiente, H, alquilo C1-8 sustituido no sustituido, halo, ciano, hidroxilo, alcoxi, nitro o R2a y R2b se toman junto con el carbono al que están unidos para formar un resto de carbonilo o un resto de cicloalquilo; cada R3a y R3b es, de modo independiente, H, alquilo C1-8 sustituido o no sustituido, halo, ciano, nitro, amino sustituido o no sustituido, hidroxilo, alcoxi, aciloxi, acilamino, arilo, heteroarilo, cicloalquilo, heterociclilo o R3a y R3b se toman junto con el carbono al que están unidos para formar un resto de carbonilo o un resto de cicloalquilo; cada X7, X8, X9 y X10 es, de modo independiente, N, CH o CR4; cada m y q es, de modo independiente, 0 o 1; cada R4 es, de modo independiente, hidroxilo, nitro, ciano, halo, perhaloalquilo C1-8, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, perhaloalcoxi C1-8, alcoxi C1-8, ariloxi, carboxilo, carbonilalcoxi, tiol, heterociclilo sustituido o no sustituido, aralquilo sustituido o no sustituido, tioalquilo, amino sustituido o no sustituido, acilamino, aminoacilo, aminocarbonilamino, aminocarboniloxi, aminosulfonilo, sulfonilamino, sulfonilo, carbonilalquilenalcoxi, alquilsulfoniIamino o acilo; cada R8a, R8b, R8c y R8d es, de modo independiente, H, hidroxilo, alcoxi, halo, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, alquilo C1-8 sustituido o no sustituido, cicloalquilo C3-8, sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, perhaloalquilo C1-8, carboxi, carbonilhalcoxi o se toma junto con un R8 geminal para formar un resto de la formula -OCH2CH2O- o se toma junto con el carbono al que está unido y un R8 geminal para formar un resto de cicloalquilo o un resto de carbonilo; cada R10a y R10b es, de modo independiente, H, alquilo C1-8 sustituido o no sustituido, halo, ciano, hidroxilo, alcoxi, nitro o R10a y R10b se toman junto con el carbono al que están unidos para formar un resto de carbonilo o un resto de cicloalquilo; cada R11 y R12 es de modo independiente, H, halo, alcoxi, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, cicloalquilo C3-8 sustituido o no sustituido, perhaloalquilo C1-8, carboxi o carbonilalcoxi y el enlace ondulado indica la presencia de una configuracion de enlace doble E o Z o R11 y R12 se toman juntos para formar un enlace; y Q es un arilo sustituido o sustituido, heteroarilo sustituido o no sustituido, cicloalquilo sustituido o no sustituido, cicloalquenilo sustituido o no sustituido, heterociclilo sustituido o no sustituido, alcoxi, aciloxi, amino sustituido o no sustituido, aminoacilo, aminocarbonilalcoxi., ciano, alquinilo, carboxi, carbonilalcoxi o acilamino; con la condicion de que, cuando X7, X8 y X10 son cada uno CH y cada R2a, R2b, R3a, R3b, R10a y R10b es hidrogeno, al menos uno de R11 y R12 es distinto de hidrogeno y R11 y R12 no se toman juntos para formar un enlace.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11051908P | 2008-10-31 | 2008-10-31 | |
| US17396009P | 2009-04-29 | 2009-04-29 | |
| US24515009P | 2009-09-23 | 2009-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073923A1 true AR073923A1 (es) | 2010-12-09 |
Family
ID=42129313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104220A AR073923A1 (es) | 2008-10-31 | 2009-10-30 | Pirido( 4,3-b) indoles que contienen restos rigidos |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8907097B2 (es) |
| EP (1) | EP2346332A4 (es) |
| JP (2) | JP5588991B2 (es) |
| CN (1) | CN102271508B (es) |
| AR (1) | AR073923A1 (es) |
| AU (1) | AU2009308706C1 (es) |
| BR (1) | BRPI0919948A2 (es) |
| CA (1) | CA2742320A1 (es) |
| HK (1) | HK1164057A1 (es) |
| TW (1) | TWI477503B (es) |
| WO (1) | WO2010051501A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| US8546381B2 (en) | 2008-03-24 | 2013-10-01 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| CA2719412A1 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies, Inc. | Pyrido[3,4-b]indoles and methods of use |
| CN102271508B (zh) | 2008-10-31 | 2015-04-29 | 梅迪维新技术公司 | 含有刚性部分的吡啶并[4，3-b]吲哚类化合物 |
| US8569287B2 (en) | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| JP5766614B2 (ja) | 2009-01-09 | 2015-08-19 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ | 神経新生促進化合物 |
| EP2396327A1 (en) | 2009-02-11 | 2011-12-21 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| AU2010242910B2 (en) * | 2009-04-29 | 2015-11-12 | Medivation Technologies, Inc. | Pyrido [4,3-b] indoles and methods of use |
| AU2010282990B2 (en) * | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
| US20120172350A1 (en) * | 2009-09-11 | 2012-07-05 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| CA2775216A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| CN102724875B (zh) | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
| AU2010298166B2 (en) * | 2009-09-23 | 2015-09-17 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
| WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
| US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103448A1 (en) * | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Methods and compositions for treating psychotic disorders using antipsychotic combination therapy |
| WO2011103430A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| JP6126528B2 (ja) | 2010-07-07 | 2017-05-10 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ | 神経新生促進化合物 |
| WO2012112965A1 (en) * | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
| CN103476417A (zh) | 2011-02-18 | 2013-12-25 | 梅迪维新技术公司 | 治疗糖尿病的化合物和方法 |
| WO2012112963A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
| WO2014031170A1 (en) * | 2012-08-22 | 2014-02-27 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| EP2887805A4 (en) * | 2012-08-22 | 2016-08-17 | Medivation Technologies Inc | COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE |
| EP2925129A4 (en) * | 2012-08-24 | 2016-06-08 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
| WO2015070234A2 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| JP6782227B2 (ja) | 2014-09-05 | 2020-11-11 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ＣａＭＫＩＩ阻害剤及びその使用 |
| EP4137208A1 (en) | 2020-03-19 | 2023-02-22 | Savchuk, Nikolay Filippovich | Noradrenergic and specific serotonergic anxiolytic and antidepressant, and method for producing same and using same |
| US20220296574A1 (en) | 2021-03-12 | 2022-09-22 | Bristol-Myers Squibb Company | Methods of treating prostate cancer |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH445511A (de) * | 1964-12-03 | 1967-10-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen Indolderivaten |
| US3525750A (en) * | 1966-05-31 | 1970-08-25 | Geigy Chem Corp | 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives |
| FR1524830A (fr) | 1966-05-31 | 1968-05-10 | Geigy Ag J R | Nouveaux dérivés de l'indole et leur préparation |
| JPS63163347A (ja) * | 1986-12-25 | 1988-07-06 | Konica Corp | 有機着色物質の光褪色防止方法 |
| US4754038A (en) * | 1987-02-26 | 1988-06-28 | American Home Products Corporation | Carboline histamine H1 antagonists |
| FR2663935A1 (fr) | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| TW470745B (en) * | 1996-05-23 | 2002-01-01 | Janssen Pharmaceutica Nv | Hexahydro-pyrido[4,3-b]indole derivatives |
| US6140337A (en) | 1997-12-23 | 2000-10-31 | Schering Corporation | Methods for the treatment of mental disorders |
| AR034264A1 (es) * | 2000-09-20 | 2004-02-18 | Upjohn Co | Derivados azepino(4,5-b)indol sustituidos y composiciones farmaceuticas |
| US7736889B2 (en) | 2003-06-10 | 2010-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Fluidic force discrimination |
| BRPI0412262A (pt) * | 2003-07-23 | 2006-09-19 | X Ceptor Therapeutics Inc | derivados de azepina como agentes farmacêuticos |
| RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
| JP2008534496A (ja) | 2005-03-22 | 2008-08-28 | アストラゼネカ・アクチエボラーグ | ＣＢ１’受容体リガンドとしての新規なテトラヒドロ−１Ｈ−ピリド［４，３−ｂ］インドール誘導体 |
| BRPI0614485A2 (pt) | 2005-07-28 | 2011-03-29 | Bristol-Myers Squibb Company | tetrahidro-1h-pirido [4, 3, b] indóis substituìdos como agonistas e antagonistas receptores de serotonina |
| WO2007041697A2 (en) | 2005-10-04 | 2007-04-12 | Medivation, Inc. | Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease |
| RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| JP2010504338A (ja) * | 2006-09-20 | 2010-02-12 | メディベイション ニューロロジー， インコーポレイテッド | 筋萎縮性側索硬化症（ＡＬＳ）の治療のための水素化ピリド［４，３−ｂ］インドール |
| US20100152225A1 (en) | 2006-09-20 | 2010-06-17 | David Hung | Hydrogenated pyrido [4,3-b] indoles such as dimebon for treating canine cognitive dysfunction syndrome |
| BRPI0718437A2 (pt) * | 2006-10-27 | 2013-11-19 | Medivation Neurology Inc | Métodos e terapias de combinação para tratar a doença de alzheimer usando, entre outros, dimebon e dolepezil |
| RU2334514C1 (ru) | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| RU2340342C2 (ru) | 2006-12-07 | 2008-12-10 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ОСТРЫХ И ХРОНИЧЕСКИХ НАРУШЕНИЙ МОЗГОВОГО КРОВООБРАЩЕНИЯ, В ТОМ ЧИСЛЕ ИНСУЛЬТА, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО[4,3-b]ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| RU2334747C1 (ru) * | 2007-04-05 | 2008-09-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| RU2339637C1 (ru) * | 2007-04-05 | 2008-11-27 | Андрей Александрович Иващенко | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием |
| JP2010528016A (ja) | 2007-05-25 | 2010-08-19 | メディベーション ニューロロジー， インコーポレイテッド | 細胞を刺激するための方法および組成物 |
| RU2338533C1 (ru) * | 2007-06-28 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| WO2009017836A1 (en) | 2007-08-01 | 2009-02-05 | Medivation Neurology, Inc. | Methods and compositions for treating schizophrenia using antipsychotic combination therapy |
| WO2009036410A1 (en) | 2007-09-14 | 2009-03-19 | Services Petroliers Schlumberger | Particle acceleration devices and methods thereof |
| WO2009039420A1 (en) | 2007-09-21 | 2009-03-26 | Medivation Neurology, Inc. | Methods and compositions for treating neuronal death mediated ocular diseases |
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| WO2009082268A2 (ru) | 2007-12-21 | 2009-07-02 | Alla Chem, Llc | ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
| RU2544856C2 (ru) * | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2009111540A1 (en) | 2008-03-04 | 2009-09-11 | Medivation Neurology, Inc. | Methods for preparing pyridylethyl-substituted carbolines |
| US8546381B2 (en) | 2008-03-24 | 2013-10-01 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| CA2719412A1 (en) * | 2008-03-24 | 2009-10-01 | Medivation Technologies, Inc. | Pyrido[3,4-b]indoles and methods of use |
| WO2009135091A1 (en) | 2008-04-30 | 2009-11-05 | Medivation Technologies, Inc. | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions |
| US8569287B2 (en) | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
| CN102271508B (zh) * | 2008-10-31 | 2015-04-29 | 梅迪维新技术公司 | 含有刚性部分的吡啶并[4，3-b]吲哚类化合物 |
| AU2010242910B2 (en) | 2009-04-29 | 2015-11-12 | Medivation Technologies, Inc. | Pyrido [4,3-b] indoles and methods of use |
| AU2010282990B2 (en) * | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
| WO2011014695A1 (en) | 2009-07-29 | 2011-02-03 | Medivation Technologies, Inc. | New 2,3,4,5-tetrahydro-1h-pyrido[4,3-b] indoles and methods of use |
| US20130137705A1 (en) * | 2009-09-23 | 2013-05-30 | Sarvajit Chakravarty | Pyrido[3,4-b]indoles and methods of use |
| CN102724875B (zh) * | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
| CA2775216A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| AU2010298166B2 (en) | 2009-09-23 | 2015-09-17 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
| US20130172320A1 (en) * | 2010-02-18 | 2013-07-04 | Sarvajit Chakravarty | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
| WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
| US9040519B2 (en) * | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103448A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Methods and compositions for treating psychotic disorders using antipsychotic combination therapy |
| WO2011103430A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
| WO2012112965A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| WO2012112963A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
| CN103476417A (zh) | 2011-02-18 | 2013-12-25 | 梅迪维新技术公司 | 治疗糖尿病的化合物和方法 |
| TWI489247B (zh) * | 2012-01-19 | 2015-06-21 | Wistron Corp | 擴充鍵盤裝置 |
| EP2887805A4 (en) | 2012-08-22 | 2016-08-17 | Medivation Technologies Inc | COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE |
| WO2014031170A1 (en) | 2012-08-22 | 2014-02-27 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
-
2009
- 2009-10-30 CN CN200980153434.2A patent/CN102271508B/zh not_active Expired - Fee Related
- 2009-10-30 US US12/610,217 patent/US8907097B2/en not_active Expired - Fee Related
- 2009-10-30 JP JP2011534826A patent/JP5588991B2/ja not_active Expired - Fee Related
- 2009-10-30 CA CA2742320A patent/CA2742320A1/en not_active Abandoned
- 2009-10-30 AU AU2009308706A patent/AU2009308706C1/en not_active Ceased
- 2009-10-30 TW TW098137048A patent/TWI477503B/zh not_active IP Right Cessation
- 2009-10-30 EP EP09824199A patent/EP2346332A4/en not_active Withdrawn
- 2009-10-30 AR ARP090104220A patent/AR073923A1/es unknown
- 2009-10-30 WO PCT/US2009/062869 patent/WO2010051501A1/en active Application Filing
- 2009-10-30 BR BRPI0919948-9A patent/BRPI0919948A2/pt not_active IP Right Cessation
-
2012
- 2012-05-18 HK HK12104892.7A patent/HK1164057A1/xx not_active IP Right Cessation
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2013
- 2013-03-08 US US13/791,544 patent/US8906925B2/en not_active Expired - Fee Related
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2014
- 2014-04-21 JP JP2014087277A patent/JP2014133759A/ja not_active Withdrawn
- 2014-11-03 US US14/531,915 patent/US9458155B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012507566A (ja) | 2012-03-29 |
| AU2009308706C1 (en) | 2016-01-21 |
| US20100216814A1 (en) | 2010-08-26 |
| CN102271508B (zh) | 2015-04-29 |
| US8907097B2 (en) | 2014-12-09 |
| US8906925B2 (en) | 2014-12-09 |
| US9458155B2 (en) | 2016-10-04 |
| EP2346332A1 (en) | 2011-07-27 |
| HK1164057A1 (en) | 2012-09-21 |
| TW201022264A (en) | 2010-06-16 |
| JP5588991B2 (ja) | 2014-09-10 |
| US20150051218A1 (en) | 2015-02-19 |
| BRPI0919948A2 (pt) | 2015-08-25 |
| AU2009308706B2 (en) | 2015-09-03 |
| WO2010051501A1 (en) | 2010-05-06 |
| AU2009308706A1 (en) | 2010-05-06 |
| TWI477503B (zh) | 2015-03-21 |
| US20130190322A1 (en) | 2013-07-25 |
| EP2346332A4 (en) | 2012-08-08 |
| CN102271508A (zh) | 2011-12-07 |
| JP2014133759A (ja) | 2014-07-24 |
| CA2742320A1 (en) | 2010-05-06 |
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