AR071756A1 - Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos. - Google Patents
Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos.Info
- Publication number
- AR071756A1 AR071756A1 ARP090101665A ARP090101665A AR071756A1 AR 071756 A1 AR071756 A1 AR 071756A1 AR P090101665 A ARP090101665 A AR P090101665A AR P090101665 A ARP090101665 A AR P090101665A AR 071756 A1 AR071756 A1 AR 071756A1
- Authority
- AR
- Argentina
- Prior art keywords
- hil
- prevention
- agent
- treatment
- autoimmune disease
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000001105 regulatory effect Effects 0.000 title 1
- 101100506090 Caenorhabditis elegans hil-2 gene Proteins 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- SJVJMFXCINSXFF-UHFFFAOYSA-N 5-(5-prop-1-ynylthiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C#CC)=CC=C1C1=CC=C(C(O)=O)S1 SJVJMFXCINSXFF-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
- 229960000310 isoleucine Drugs 0.000 abstract 2
- 210000003289 regulatory T cell Anatomy 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 102000055277 human IL2 Human genes 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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Abstract
Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune, un agente para la formacion de celulas T reguladoras (Treg) en un ser vivo, as¡ como diversos procedimientos, en los que se usan los agentes segun la invencion. Reivindicacion 1: Uso de una mute¡na de interleuquina-2 humana (mute¡na de hIL-2) o una de sus partes, que est numerada segun la hIL-2 de tipo salvaje y que presenta una sustitucion de amino cido en al menos una de las posiciones 20, 88 o 126, para preparar un medicamento para el tratamiento y/o la prevencion de una enfermedad autoinmune. Reivindicacion 2: Uso de acuerdo con la reivindicacion 1, caracterizado porque por sustitucion en la posicion 88 se intercambia una asparagina por arginina (hIL-2-N88R), o por una glicina (hIL-2-N88G) o por una isoleucina (hIL-2-N88I). Reivindicacion 3: Uso de acuerdo con la reivindicacion 1 o 2, caracterizado porque por sustitucion en la posicion 20 se intercambia un cido asp rtico por una histidina (hIL-2-D20H) o por una isoleucina (hIL-2-D20H) o por una tirosina (hIL-2-D20Y). Reivindicacion 4: Uso de acuerdo con una de las reivindicaciones precedentes, caracterizado porque por sustitucion en la posicion 126 se intercambia una glutamina por una leucina (hIL-2-Q126L). Reivindicacion 7: Uso de acuerdo con una de las reivindicaciones precedentes, caracterizado porque el medicamento presenta adicionalmente un inmunosupresor. Reivindicacion 11: Medicamento para el tratamiento y/o la prevencion de una enfermedad autoinmune, caracterizado porque presenta la mute¡na de hIL-2 o una parte de ella segun el uso de acuerdo con una de las reivindicaciones 1 a 10. Reivindicacion 21: Agente para la formacion de celulas T reguladoras (Treg) en un ser vivo, caracterizado porque presenta la mute¡na de hIL-2 o una parte de ella segun el uso de acuerdo con una de las reivindicaciones 12 a 20.
Applications Claiming Priority (1)
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