AR067904A1 - Derivados de piperazina-amida - Google Patents
Derivados de piperazina-amidaInfo
- Publication number
- AR067904A1 AR067904A1 ARP080103496A ARP080103496A AR067904A1 AR 067904 A1 AR067904 A1 AR 067904A1 AR P080103496 A ARP080103496 A AR P080103496A AR P080103496 A ARP080103496 A AR P080103496A AR 067904 A1 AR067904 A1 AR 067904A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- heteroaryl
- aryl
- heterocyclyl
- fluor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
Estos compuestos se fijan sobre LXR alfa y LXR beta y pueden utilizarse como medicamentos para usar para enfermedades como diabetes mellitus, alzheimer, de la piel, cáncer, HIV, antilipídico. Procesos y composiciones farmacéuticas. Reivindicacion 1: Compuestos de la formula (1) en la que X es N o CH; Y es N o CH; R1 es alquilo inferior, (alcoxi inferior)-alquilo inferior, halogeno-alquilo inferior, alquenilo inferior, cicloalquilo, cicloalquil-alquilo inferior, arilo, aril-alquilo inferior, heterociclilo, heterociclil-alquilo inferior, heteroarilo o heteroaril-alquilo inferior, en los que un cicloalquilo, arilo, heterociclilo o heteroarilo puede estar opcionalmente sustituido por 1-5 sustituyentes elegidos con independencia entre el grupo formado por halogeno, alquilo inferior, alcoxi inferior, fluoralquilo inferior y fluor-alcoxi inferior; R2 es alquilo inferior, fluor-alquilo inferior, (alcoxi inferior)-alquilo inferior, cicloalquilo, cicloalquilalquilo inferior, arilo, aril-alquilo inferior, heterociclilo, heterociclil-alquilo inferior, heteroarilo o heteroaril-alquilo inferior, en los que un cicloalquilo, arilo, heterociclilo o heteroarilo puede estar opcionalmente sustituido por 1-5 sustituyentes elegidos con independencia entre el grupo formado por halogeno, alquilo inferior, alcoxi inferior, fluor-alquilo inferior, fluor-alcoxi inferior, alcoxi inferior-carbonilo y fenilo; R3 es arilo o heteroarilo, dicho arilo o heteroarilo puede estar opcionalmente sustituido por 1-5 sustituyentes elegidos con independencia entre el grupo formado por halogeno, CN, alquilo inferior, fluor-alquilo inferior, alcoxi inferior y fluor-alcoxi inferior; R4, R5, R6, R7, R8, R9, R10 y R11 con independencia entre sí son hidrogeno o alquilo inferior, o R4 y R5 están unidos entre sí, o R6 y R7 están unidos entre sí, o R8 y R9 están unidos entre sí, o R10 y R11 están unidos entre sí, para formar un anillo junto con el átomo de carbono al que están unidos, y -R4-R5-, -R6-R7-, -R8-R9- y/o -R10-R11- es -(CH2)2-6-; y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07114219 | 2007-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067904A1 true AR067904A1 (es) | 2009-10-28 |
Family
ID=40298643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103496A AR067904A1 (es) | 2007-08-13 | 2008-08-11 | Derivados de piperazina-amida |
Country Status (17)
Country | Link |
---|---|
US (1) | US8288541B2 (es) |
EP (1) | EP2188266B1 (es) |
JP (1) | JP5220858B2 (es) |
KR (1) | KR101171507B1 (es) |
CN (2) | CN103772299A (es) |
AR (1) | AR067904A1 (es) |
AU (1) | AU2008288537B2 (es) |
BR (1) | BRPI0815479A2 (es) |
CA (1) | CA2695088C (es) |
CL (1) | CL2008002356A1 (es) |
ES (1) | ES2393822T3 (es) |
MX (1) | MX2010001742A (es) |
PE (1) | PE20090592A1 (es) |
RU (1) | RU2454412C2 (es) |
TW (1) | TWI364420B (es) |
WO (1) | WO2009021868A2 (es) |
ZA (1) | ZA201001061B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012033353A2 (ko) | 2010-09-07 | 2012-03-15 | 서울대학교 산학협력단 | 세스터터핀 화합물 및 이들 물질의 용도 |
CN103172635B (zh) * | 2011-12-21 | 2016-04-27 | 上海医药工业研究院 | 哌嗪或哌啶类化合物、其盐、中间体、制备方法及应用 |
SG11201405378VA (en) | 2012-03-02 | 2014-09-26 | Anayaderm Inc | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
EP2882496B1 (en) | 2012-08-13 | 2019-10-09 | The Rockefeller University | Treatment and diagnosis of melanoma |
EP3041834A4 (en) | 2013-09-04 | 2017-01-18 | Ralexar Therapeutics, Inc. | Liver x receptor (lxr) modulators |
EP3626712A3 (en) | 2013-09-04 | 2020-04-15 | Ellora Therapeutics, Inc. | Liver x receptor (lxr) modulators |
EP3091970B1 (en) | 2014-01-10 | 2020-10-28 | Rgenix, Inc. | Lxr agonists and uses thereof |
AU2017207291B2 (en) | 2016-01-11 | 2023-06-15 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
BR112019005297A2 (pt) * | 2016-09-21 | 2019-06-04 | Vectus Biosystems Ltd | composto, composição farmacêutica, e, métodos para tratamento de hipertensão ou pré-hipertensão e de fibrose. |
CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
MX2022007164A (es) | 2019-12-13 | 2022-09-12 | Inspirna Inc | Sales metálicas y usos de estas. |
KR20220152159A (ko) * | 2021-05-07 | 2022-11-15 | 엠비디 주식회사 | 신규한 헤테로사이클 화합물 및 이의 용도 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US530238A (en) * | 1894-12-04 | Guard for lathes | ||
DK350383A (da) | 1982-08-27 | 1984-02-28 | Hoffmann La Roche | Phosphorforbindelser |
EP0398132B1 (de) | 1989-05-18 | 1995-09-20 | F. Hoffmann-La Roche Ag | Phosphorverbindungen |
WO1992016535A1 (de) | 1991-03-15 | 1992-10-01 | F.Hoffmann-La Roche Ag | Diphosphonsaure derivate als zwischenprodukte in der herstellung von diphosphinliganden |
US5256321A (en) | 1992-07-10 | 1993-10-26 | The Lubrizol Corporation | Grease compositions |
CN1164232A (zh) * | 1994-09-26 | 1997-11-05 | 曾尼卡有限公司 | 作为抗血栓形成剂或抗凝血剂的氨基杂环衍生物 |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
MXPA04011691A (es) | 2002-05-24 | 2005-09-12 | Pharmacia Corp | Moduladores del receptor x anilino hepaticos. |
PL375527A1 (en) * | 2002-06-29 | 2005-11-28 | Zentaris Gmbh | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases |
WO2004076418A1 (en) * | 2003-02-28 | 2004-09-10 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
FR2869904B1 (fr) * | 2004-05-07 | 2006-07-28 | Fournier S A Sa Lab | Modulateurs des recepteurs lxr |
AU2005267331A1 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
DE102005000666B3 (de) * | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2142533B1 (en) * | 2007-03-30 | 2011-11-16 | F. Hoffmann-La Roche AG | Imidazolidinone derivatives |
-
2008
- 2008-08-04 CN CN201410037876.3A patent/CN103772299A/zh active Pending
- 2008-08-04 RU RU2010108943/04A patent/RU2454412C2/ru not_active IP Right Cessation
- 2008-08-04 CN CN200880103083.XA patent/CN101778831B/zh not_active Expired - Fee Related
- 2008-08-04 BR BRPI0815479-1A2A patent/BRPI0815479A2/pt not_active IP Right Cessation
- 2008-08-04 AU AU2008288537A patent/AU2008288537B2/en not_active Ceased
- 2008-08-04 MX MX2010001742A patent/MX2010001742A/es active IP Right Grant
- 2008-08-04 EP EP08786826A patent/EP2188266B1/en not_active Not-in-force
- 2008-08-04 ES ES08786826T patent/ES2393822T3/es active Active
- 2008-08-04 KR KR1020107005485A patent/KR101171507B1/ko not_active IP Right Cessation
- 2008-08-04 CA CA2695088A patent/CA2695088C/en not_active Expired - Fee Related
- 2008-08-04 WO PCT/EP2008/060213 patent/WO2009021868A2/en active Application Filing
- 2008-08-04 JP JP2010520529A patent/JP5220858B2/ja not_active Expired - Fee Related
- 2008-08-06 US US12/186,555 patent/US8288541B2/en not_active Expired - Fee Related
- 2008-08-11 CL CL2008002356A patent/CL2008002356A1/es unknown
- 2008-08-11 AR ARP080103496A patent/AR067904A1/es not_active Application Discontinuation
- 2008-08-11 PE PE2008001361A patent/PE20090592A1/es not_active Application Discontinuation
- 2008-08-12 TW TW097130742A patent/TWI364420B/zh active
-
2010
- 2010-02-12 ZA ZA2010/01061A patent/ZA201001061B/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2010108943A (ru) | 2011-09-20 |
TW200916463A (en) | 2009-04-16 |
CN101778831B (zh) | 2014-08-20 |
US20090048264A1 (en) | 2009-02-19 |
CA2695088C (en) | 2013-03-12 |
PE20090592A1 (es) | 2009-05-03 |
ZA201001061B (en) | 2010-11-24 |
ES2393822T3 (es) | 2012-12-28 |
BRPI0815479A2 (pt) | 2015-02-10 |
AU2008288537B2 (en) | 2011-03-24 |
RU2454412C2 (ru) | 2012-06-27 |
MX2010001742A (es) | 2010-03-10 |
EP2188266A2 (en) | 2010-05-26 |
CN103772299A (zh) | 2014-05-07 |
US8288541B2 (en) | 2012-10-16 |
AU2008288537A1 (en) | 2009-02-19 |
CL2008002356A1 (es) | 2009-05-29 |
WO2009021868A3 (en) | 2009-04-09 |
EP2188266B1 (en) | 2012-10-17 |
CN101778831A (zh) | 2010-07-14 |
TWI364420B (en) | 2012-05-21 |
JP5220858B2 (ja) | 2013-06-26 |
WO2009021868A2 (en) | 2009-02-19 |
CA2695088A1 (en) | 2009-02-19 |
KR20100043096A (ko) | 2010-04-27 |
JP2010535834A (ja) | 2010-11-25 |
KR101171507B1 (ko) | 2012-08-07 |
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