AR066095A1 - Compuesto de oxadiazol su uso para preparar un medicamento composicion farmaceutica que lo comprende y procedimiento para prepararla - Google Patents

Compuesto de oxadiazol su uso para preparar un medicamento composicion farmaceutica que lo comprende y procedimiento para prepararla

Info

Publication number
AR066095A1
AR066095A1 ARP080101584A ARP080101584A AR066095A1 AR 066095 A1 AR066095 A1 AR 066095A1 AR P080101584 A ARP080101584 A AR P080101584A AR P080101584 A ARP080101584 A AR P080101584A AR 066095 A1 AR066095 A1 AR 066095A1
Authority
AR
Argentina
Prior art keywords
prepare
halogen
compound
procedure
pharmaceutical composition
Prior art date
Application number
ARP080101584A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0707617A external-priority patent/GB0707617D0/en
Priority claimed from GB0805993A external-priority patent/GB0805993D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR066095A1 publication Critical patent/AR066095A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Compuesto de oxadiazol de la formula (1) o sales del mismo: en la que uno de R5 y R6 es hidrogeno o R2 y el otro es formula (2), uno de R3 y R4 es formula (3); A es un fenilo o un anillo heteroarilo de 5 o 6 miembros; R1 es H o representa hasta tressustituyentes seleccionados independientemente entre halogeno, alquilo C1-4, alcoxi C1-4, cicloalquilo C5-7, cicloalcoxi C5-7, trifluorometoxi, difluorometoxi, trifluorometilo, ciano, fenilo, anillos heteroarilo de 5 o 6 miembros, piperidinilo ypirroIidiniIo; R2 es hidrogeno o representa hasta tres sustituyentes seleccionados independientemente entre halogeno, alquilo C1-4, alcoxi C1-4, trifluorometoxi, difluorometoxi, trifluorometilo, y ciano; R7 es H o halogeno; Z es alquilo C1-4 quepuede estar opcionalmente interrumpido una vez por N o O y que puede estar opcionalmente sustituido sobre C con hasta cuatro sustituyentes seleccionados independientemente entre halogeno, metilo e hidroxilo, con la condicion de que ningun átomo decarbono esté sustituido con dos grupos hidroxilo. Uso de dicho compuesto para preparar un medicamento par el tratamiento de enfermedades o trastornos mediados por los receptores S1P1, tal como esclerosis multiple. Composicion farmacéutica que locomprende y procedimiento para prepararla.
ARP080101584A 2007-04-19 2008-04-17 Compuesto de oxadiazol su uso para preparar un medicamento composicion farmaceutica que lo comprende y procedimiento para prepararla AR066095A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0707617A GB0707617D0 (en) 2007-04-19 2007-04-19 Compounds
GB0805993A GB0805993D0 (en) 2008-04-02 2008-04-02 Compounds

Publications (1)

Publication Number Publication Date
AR066095A1 true AR066095A1 (es) 2009-07-22

Family

ID=39604751

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101584A AR066095A1 (es) 2007-04-19 2008-04-17 Compuesto de oxadiazol su uso para preparar un medicamento composicion farmaceutica que lo comprende y procedimiento para prepararla

Country Status (25)

Country Link
US (1) US8324254B2 (es)
EP (1) EP2137181B1 (es)
JP (1) JP5313229B2 (es)
KR (1) KR20090130062A (es)
AR (1) AR066095A1 (es)
AT (1) ATE500252T1 (es)
AU (1) AU2008240773B2 (es)
BR (1) BRPI0809472A2 (es)
CA (1) CA2684385A1 (es)
CL (1) CL2008001099A1 (es)
CO (1) CO6321136A2 (es)
CR (1) CR11119A (es)
DE (1) DE602008005285D1 (es)
DO (1) DOP2009000237A (es)
EA (1) EA016443B1 (es)
HK (1) HK1138001A1 (es)
IL (1) IL200870A (es)
JO (1) JO2686B1 (es)
MA (1) MA31311B1 (es)
MX (1) MX2009011155A (es)
MY (1) MY146606A (es)
NZ (1) NZ579595A (es)
PE (1) PE20090150A1 (es)
TW (1) TWI408137B (es)
WO (1) WO2008128951A1 (es)

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Also Published As

Publication number Publication date
ATE500252T1 (de) 2011-03-15
PE20090150A1 (es) 2009-05-08
JP5313229B2 (ja) 2013-10-09
JP2010524886A (ja) 2010-07-22
EP2137181B1 (en) 2011-03-02
US8324254B2 (en) 2012-12-04
MY146606A (en) 2012-09-14
MA31311B1 (fr) 2010-04-01
HK1138001A1 (en) 2010-08-13
IL200870A0 (en) 2010-05-17
CO6321136A2 (es) 2011-09-20
US20100113528A1 (en) 2010-05-06
IL200870A (en) 2013-08-29
CR11119A (es) 2010-01-18
KR20090130062A (ko) 2009-12-17
EA200970967A1 (ru) 2010-02-26
EP2137181A1 (en) 2009-12-30
CL2008001099A1 (es) 2008-10-24
NZ579595A (en) 2012-06-29
DOP2009000237A (es) 2010-05-31
DE602008005285D1 (de) 2011-04-14
BRPI0809472A2 (pt) 2014-09-09
TWI408137B (zh) 2013-09-11
AU2008240773A1 (en) 2008-10-30
AU2008240773B2 (en) 2013-10-03
JO2686B1 (en) 2013-03-03
CA2684385A1 (en) 2008-10-30
TW200911794A (en) 2009-03-16
MX2009011155A (es) 2009-10-30
WO2008128951A1 (en) 2008-10-30
EA016443B1 (ru) 2012-05-30

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