AR067076A1 - Inhibidores nucleosidos de la transcriptasa inversa - Google Patents

Inhibidores nucleosidos de la transcriptasa inversa

Info

Publication number
AR067076A1
AR067076A1 ARP080102629A ARP080102629A AR067076A1 AR 067076 A1 AR067076 A1 AR 067076A1 AR P080102629 A ARP080102629 A AR P080102629A AR P080102629 A ARP080102629 A AR P080102629A AR 067076 A1 AR067076 A1 AR 067076A1
Authority
AR
Argentina
Prior art keywords
alkyl
treatment
haloalkyl
halogen
hiv
Prior art date
Application number
ARP080102629A
Other languages
English (en)
Inventor
Todd Richard Elworthy
Joan Heather Hogg
Joshua Kennedy-Smith
Counde O Yang
Mark Smith
Zachary Kevin Sweeney
Jeffrey Wu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR067076A1 publication Critical patent/AR067076A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inhiben la transcriptasa inversa del VIH-1 y consiguen un método para la prevencion y tratamiento de las infecciones por VIH-1 y el tratamiento del SIDA y/o CRS. La presente también está relacionada con las composiciones que contienen compuestos de formula 1 utiles para la prevencion y tratamiento de las infecciones por VIH-1 y el tratamiento del SIDA y/o CRS. Reivindicacion 1: Un compuesto de acuerdo con la formula 1 en el que X es O o NR2; R1 es halogeno, alquilo C1-6, cicloalquilo C3-7, haloalquilo C1-6 o alcoxi C1-6; R2 y R3 independientemente son (i) hidrogeno o alquilo C1-6, (ii) R2 y R3 juntos son (CH2)n, orto-fenileno, piridinileno, 3,4-piridazileno o CH=N, en el que n es un numero entero de 2 a 4 y un átomo de nitrogeno en dicho anillo piridinileno o 3,4-piridazileno puede estar opcionalmente sustituido con un oxígeno; o, (iii) R2 es hidrogeno y R3 es fenilo opcionalmente sustituido con entre uno y tres sustituyentes opcionalmente seleccionados de entre el grupo que consiste en alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, halogeno, ciano y nitro; Ar es fenilo sustituido con de 1-3 grupos independientemente seleccionados del grupo que consiste en halogeno, ciano, haloalquilo C1-6, alquilo C1-6; o las sales farmacéuticamente aceptable de los mismos.
ARP080102629A 2007-06-22 2008-06-20 Inhibidores nucleosidos de la transcriptasa inversa AR067076A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93695607P 2007-06-22 2007-06-22

Publications (1)

Publication Number Publication Date
AR067076A1 true AR067076A1 (es) 2009-09-30

Family

ID=39811644

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102629A AR067076A1 (es) 2007-06-22 2008-06-20 Inhibidores nucleosidos de la transcriptasa inversa

Country Status (15)

Country Link
US (1) US7947709B2 (es)
EP (1) EP2170836A1 (es)
JP (1) JP2010530863A (es)
KR (1) KR20100039348A (es)
CN (1) CN101784529A (es)
AR (1) AR067076A1 (es)
AU (1) AU2008267895A1 (es)
BR (1) BRPI0813404A2 (es)
CA (1) CA2692182A1 (es)
CL (1) CL2008001819A1 (es)
IL (1) IL202737A0 (es)
MX (1) MX2009013865A (es)
PE (1) PE20090419A1 (es)
TW (1) TW200911804A (es)
WO (1) WO2009000663A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145562A1 (en) * 2007-05-30 2008-12-04 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
EP1377556B1 (en) 2001-04-10 2007-04-04 Pfizer Limited Pyrazole derivatives for treating hiv
GB0113524D0 (en) 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
JP2006504803A (ja) 2002-09-26 2006-02-09 ファイザー・インク ピラゾール誘導体
BR0314759A (pt) 2002-09-26 2005-07-26 Pfizer Derivados de pirazol
GB0223232D0 (en) 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
CN100469769C (zh) 2003-03-24 2009-03-18 弗·哈夫曼-拉罗切有限公司 作为逆转录酶抑制剂的苄基-哒嗪酮
TW200505441A (en) 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
CA2559552A1 (en) 2004-03-23 2005-09-29 F. Hoffmann-La Roche Ag Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
JP4675959B2 (ja) 2004-07-27 2011-04-27 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としてのベンジルトリアゾロン化合物
SE0401971D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
WO2006034583A1 (en) 2004-09-30 2006-04-06 Boehringer Ingelheim International Gmbh & Co Kg Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors
EP1831157A2 (en) 2004-12-22 2007-09-12 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
CA2600759A1 (en) 2005-03-24 2006-09-28 F. Hoffmann-La Roche Ag 1,2,4-triazole-5-one compounds as heterocyclic reverse transcriptase inhibitors
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
JP2009510013A (ja) 2005-09-30 2009-03-12 エフ．ホフマン−ラ ロシュ アーゲー Ｎｎｒｔ阻害剤
ES2320042T3 (es) 2005-10-19 2009-05-18 F. Hoffmann-La Roche Ag Inhibidores de transcriptasa reversa con nucleosidos de n-fenil fenilacetamida.
EP1940781A1 (en) 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u

Also Published As

Publication number Publication date
IL202737A0 (en) 2010-06-30
US20090012034A1 (en) 2009-01-08
TW200911804A (en) 2009-03-16
CN101784529A (zh) 2010-07-21
EP2170836A1 (en) 2010-04-07
JP2010530863A (ja) 2010-09-16
CL2008001819A1 (es) 2009-05-22
CA2692182A1 (en) 2008-12-31
US7947709B2 (en) 2011-05-24
BRPI0813404A2 (pt) 2014-12-30
MX2009013865A (es) 2010-01-27
PE20090419A1 (es) 2009-04-18
AU2008267895A1 (en) 2008-12-31
KR20100039348A (ko) 2010-04-15
WO2009000663A1 (en) 2008-12-31

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