AR065785A1 - Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro - Google Patents

Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro

Info

Publication number
AR065785A1
AR065785A1 ARP080101125A ARP080101125A AR065785A1 AR 065785 A1 AR065785 A1 AR 065785A1 AR P080101125 A ARP080101125 A AR P080101125A AR P080101125 A ARP080101125 A AR P080101125A AR 065785 A1 AR065785 A1 AR 065785A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
independently
alkyl
hydrogen
heteroaryl
Prior art date
Application number
ARP080101125A
Other languages
English (en)
Inventor
Rajender Kamboj
Vishnumurthy Kodumuru
Jianyu Sun
Shifeng Liu
Mikhail Chafeev
Johnathan Langille
Jianmin Fu
Serguei Sviridov
Nagasree Chakka
Jean-Jacques Cadieux
Zaihui Zhang
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of AR065785A1 publication Critical patent/AR065785A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Reivindicacion 1: Un compuesto de la formula (1), caracterizado porque n y m son cada uno, de modo independiente, 1, 2, 3, 4, 5, 6 o 7; el anillo A y B son cada uno, de modo independiente, arilo o heteroarilo; R1 es un enlace directo, -O-, -S(O)p- (donde p es 0, 1 o 2), -C(R4)2-, C(O)- o -N(R4)-; al menos un R2 y al menos un R3 está seleccionado, de modo independiente, del grupo que consiste en -R6-S-C(=NR4)N(R4)R5, -R6-S-C(=NR4)N(R4)N(R4)R5, -R6-O-C(=NR4)N(R4)R5, -R6-C(O)-N=C[N(R4)(R5)]N(R4)R5, -R6-C(=NR4)N(R4)R5, -R6-C(=NCN)N(R4)R5 y -R6-N(R7)C(=NR4)N(R4)R5; y los otros R2 y R3, de estar presentes, están seleccionados cada uno, de modo independiente, del grupo que consiste en alquilo, halo, haloalquilo, -R6-OR7, -R6-CN, -R6-NO2, -R6-N(R8)2, -R-C(O)OR8, -R6-C(O)N(R8)2, -N(R8)S(O)tR9, -S(O)tOR9, -S(O)pR8, -S(O)tN(R8)2, -R6-S-C(=NR4)N(R4)R5, -R6-O-C(=NR4)N(R4)R5, -R6-C(=NR4)N(R4)R5, y -R6-N(R7)-C(=NR4)N(R4)R5, en donde cada t es, de modo independiente 1 o 2 y cada p es 0, 1 o 2; cada R4 y R5 es, de modo independiente, hidrogeno, alquilo, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclilo opcionalmente sustituido, heteroarilo opcionalmente sustituido o heteroaralquilo opcionalmente sustituido; cada R6 es, de modo independiente, un enlace directo o una cadena de alquileno lineal o ramificada; cada R7 es hidrogeno, alquilo, alquenilo, alquinilo, haloalquilo, alcoxialquilo, cicloalquilo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heterociclilo opcionalmente sustituido, heterociclilalquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido o heteroarilalquilo opcionalmente sustituido; cada R8 es, de modo independiente, hidrogeno o alquilo; y cada R9 es alquilo; en forma de uno de sus estereoisomeros, enantiomeros, tautomeros o sus mezclas; o una de sus sales solvatos o profármacos farmacéuticamente aceptables.
ARP080101125A 2007-03-19 2008-03-18 Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro AR065785A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89566207P 2007-03-19 2007-03-19

Publications (1)

Publication Number Publication Date
AR065785A1 true AR065785A1 (es) 2009-07-01

Family

ID=39551662

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101125A AR065785A1 (es) 2007-03-19 2008-03-18 Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro

Country Status (13)

Country Link
US (1) US20080234384A1 (es)
EP (1) EP2061754A1 (es)
JP (1) JP2010522197A (es)
CN (1) CN101622227A (es)
AR (1) AR065785A1 (es)
AU (1) AU2008228898A1 (es)
BR (1) BRPI0809272A2 (es)
CA (1) CA2678949A1 (es)
CL (1) CL2008000794A1 (es)
MX (1) MX2009010083A (es)
RU (1) RU2009138351A (es)
TW (1) TW200843733A (es)
WO (1) WO2008115999A1 (es)

Families Citing this family (16)

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WO2010005851A1 (en) * 2008-07-08 2010-01-14 Xenon Pharmaceuticals Inc. Combination therapy for treating iron disorders
US20100222381A1 (en) 2009-02-27 2010-09-02 Hariprasad Vankayalapati Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
GB0903482D0 (en) * 2009-02-27 2009-04-08 Ucl Business Plc New compounds
CN102574805A (zh) 2009-08-20 2012-07-11 维福（国际）股份公司 新型喹啉铁调素拮抗剂
AR077958A1 (es) 2009-08-27 2011-10-05 Vifor Int Ag Quinoxalinonas antagonistas de la hepcidina
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
TW201113274A (en) 2009-09-07 2011-04-16 Vifor Int Ag Novel ethanediamine hepcidine antagonists
WO2011029832A1 (de) 2009-09-09 2011-03-17 Vifor (International) Ag Neue thiazol- und oxazol-hepcidin-antagonisten
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
CN103073528A (zh) * 2012-12-21 2013-05-01 北京万全德众医药生物技术有限公司 草酸艾司西酞普兰杂质a的制备方法
CN104370784B (zh) * 2014-12-11 2017-02-22 北京彤程创展科技有限公司 一种环烷基硫化锌化合物及其制备方法
SG11201802480YA (en) 2015-10-23 2018-05-30 Vifor Int Ag Novel ferroportin inhibitors
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
TW202102478A (zh) 2019-04-01 2021-01-16 瑞士商威佛（國際）股份有限公司 新穎的鐵螯合物
WO2024035268A2 (en) * 2022-08-10 2024-02-15 Qatar Foundation For Education, Science And Community Development Tau pathway modulators

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US3247035A (en) * 1962-09-28 1966-04-19 Standard Oil Co Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst
NL134627C (es) * 1966-10-27
FR1541946A (fr) * 1966-10-27 1968-10-11 Geigy Ag J R Amines et produits d'entretien des surfaces contenant ces amines
US3636109A (en) * 1969-02-05 1972-01-18 Dow Chemical Co 2 2'-isopropylidenebis((6 - lower alkoxy-m-phenylene)methylene)bis(2 - thiopseudourea) dihydrochlori
JPH0791260B2 (ja) * 1986-12-27 1995-10-04 第一製薬株式会社 グアニジン誘導体及びその塩
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
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DK1311499T3 (da) * 2000-08-08 2006-08-07 Ortho Mcneil Pharm Inc Bicycliske forbindelser som H3-receptorligander
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Also Published As

Publication number Publication date
CN101622227A (zh) 2010-01-06
WO2008115999A8 (en) 2008-12-24
AU2008228898A1 (en) 2008-09-25
CL2008000794A1 (es) 2008-05-30
RU2009138351A (ru) 2011-04-27
JP2010522197A (ja) 2010-07-01
TW200843733A (en) 2008-11-16
EP2061754A1 (en) 2009-05-27
WO2008115999A1 (en) 2008-09-25
US20080234384A1 (en) 2008-09-25
BRPI0809272A2 (pt) 2014-10-14
MX2009010083A (es) 2009-10-12
CA2678949A1 (en) 2008-09-25

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