AR061472A1 - Elementos reguladores de acido nucleico - Google Patents

Elementos reguladores de acido nucleico

Info

Publication number
AR061472A1
AR061472A1 ARP070102632A ARP070102632A AR061472A1 AR 061472 A1 AR061472 A1 AR 061472A1 AR P070102632 A ARP070102632 A AR P070102632A AR P070102632 A ARP070102632 A AR P070102632A AR 061472 A1 AR061472 A1 AR 061472A1
Authority
AR
Argentina
Prior art keywords
elements
gene
expression
product
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP070102632A
Other languages
English (en)
Inventor
Barbara Enenkel
Kerstin Sautter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR061472A1 publication Critical patent/AR061472A1/es
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a secuencias de ADN, en especial a elementos que aumentan la transcripcion o bien la expresion (elementos TE), así como su uso en un vector de expresion en union con un potenciador, un promotor, un gen de producto y un marcador de seleccion. La presente describe un gen de producto N° 1 y los elementos TE TE-01, -02, -03, -04, -06, -07, - 08, -10, -11 o -12. Debido a su pequeno tamano, se prefieren en especial TE-06, TE-07 o TE-08. La secuencia N°1 proviene de una region de secuencias que está corriente arriba de la region codificadora del gen Ub/S27a de células CHO. Los elementos TE producen un aumento de la expresion del producto génico en especial con una integracion estable en el genoma eucarionte, con preferencia el genoma CHO-DG44. Los efectos de posicion cromosomicos se vencen, protegen o anulan. De esta manera, se aumenta hasta siete veces la proporcion de grandes productores de una preparacion de transfeccion, como también el nivel de expresion absoluto.
ARP070102632A 2006-07-26 2007-06-15 Elementos reguladores de acido nucleico Pending AR061472A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06117862 2006-07-26

Publications (1)

Publication Number Publication Date
AR061472A1 true AR061472A1 (es) 2008-08-27

Family

ID=37441548

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102632A Pending AR061472A1 (es) 2006-07-26 2007-06-15 Elementos reguladores de acido nucleico

Country Status (23)

Country Link
US (3) US20080124760A1 (es)
EP (1) EP2049671B1 (es)
JP (1) JP5270544B2 (es)
KR (1) KR101485853B1 (es)
CN (1) CN101517085B (es)
AR (1) AR061472A1 (es)
AU (1) AU2007278368B2 (es)
BR (1) BRPI0714594A2 (es)
CA (1) CA2658595C (es)
CY (1) CY1113711T1 (es)
DK (1) DK2049671T3 (es)
EA (1) EA016880B1 (es)
ES (1) ES2401654T3 (es)
HK (1) HK1134107A1 (es)
IL (1) IL196676A0 (es)
MX (1) MX2009000781A (es)
NO (1) NO20090057L (es)
NZ (1) NZ575115A (es)
PL (1) PL2049671T3 (es)
PT (1) PT2049671E (es)
SI (1) SI2049671T1 (es)
TW (1) TW200815591A (es)
WO (1) WO2008012142A1 (es)

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Also Published As

Publication number Publication date
HK1134107A1 (en) 2010-04-16
AU2007278368A1 (en) 2008-01-31
ES2401654T3 (es) 2013-04-23
JP5270544B2 (ja) 2013-08-21
CN101517085B (zh) 2013-08-07
SI2049671T1 (sl) 2013-04-30
PT2049671E (pt) 2013-01-24
US9045776B2 (en) 2015-06-02
EA200900212A1 (ru) 2009-10-30
US20150337333A1 (en) 2015-11-26
JP2009544293A (ja) 2009-12-17
EP2049671B1 (de) 2012-12-19
KR101485853B1 (ko) 2015-01-23
IL196676A0 (en) 2011-08-01
TW200815591A (en) 2008-04-01
CA2658595C (en) 2016-05-31
EP2049671A1 (de) 2009-04-22
KR20090046887A (ko) 2009-05-11
CN101517085A (zh) 2009-08-26
WO2008012142A1 (de) 2008-01-31
EA016880B1 (ru) 2012-08-30
CA2658595A1 (en) 2008-01-31
US20100311121A1 (en) 2010-12-09
BRPI0714594A2 (pt) 2013-02-19
US20080124760A1 (en) 2008-05-29
US9708626B2 (en) 2017-07-18
AU2007278368B2 (en) 2013-12-19
CY1113711T1 (el) 2016-06-22
NO20090057L (no) 2009-02-16
PL2049671T3 (pl) 2013-05-31
MX2009000781A (es) 2009-01-29
NZ575115A (en) 2011-10-28
DK2049671T3 (da) 2013-04-08

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