AR061206A1 - Pirido[3,2-e]pirazinas, su uso como inhibidores de la fosfodiesterasa 10, y procesos para prepararlas - Google Patents
Pirido[3,2-e]pirazinas, su uso como inhibidores de la fosfodiesterasa 10, y procesos para prepararlasInfo
- Publication number
- AR061206A1 AR061206A1 ARP070102310A ARP070102310A AR061206A1 AR 061206 A1 AR061206 A1 AR 061206A1 AR P070102310 A ARP070102310 A AR P070102310A AR P070102310 A ARP070102310 A AR P070102310A AR 061206 A1 AR061206 A1 AR 061206A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cyclic radical
- halo
- optionally mono
- polysubstituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Pirido[3,2-e]pirazinas, procesos para prepararlas, preparaciones farmacéuticas que comprenden estos compuestos y al uso farmacéutico de estos compuestos, que son inhibidores de la fosfodiesterasa 10, como compuestos activos para tratar enfermedades de mamíferos, que incluyen a un ser humano, que pueden ser influidos por el uso de los compuesto para inhibir la actividad de la fosfodiesterasa 10 en el sistema nervioso central. Más particularmente, tratamiento de trastornos neurologicos y psiquiátricos, por ejemplo psicosis y trastornos que comprenden déficits cognitivos como síntomas. Reivindicacion 1: Compuestos caracterizados porque formula (1) donde el enlace entre A y N es un enlace simple o un doble enlace, A es C cuando el enlace es un doble enlace y CH cuando el enlace es un enlace simple, m es 0 o 1, n es 0 o 1, donde R1 es R2 se seleccionan independientemente de H, un radical cíclico, alquilo C1-8, opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, alquenilo C2-8, opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, alquilinilo C2-8, opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, un sistema anular carbocíclico saturado, monoinsaturado o poliinsaturado con 3 a 8 átomos o un sistema anular heterocíclico con 5 a 15 átomos anulares, cada uno opcionalmente mono- o poliinsaturado con halo, amino, alquilamino C1-3, di-alquilamino C1-3, nitro, alquilo C1-3, O-alquilo C1-3 y/o un radical cíclico y R3 se selecciona de H, un radical cíclico, N3, CN, R6, OR6, SR6, SOR6, SO2R6, NH(CO)OR6, N((CO)OR6)2, NR6 ((CO)OR6), NH-(C=O)-NH2, NR6-(C=O)-NH2, NR6-(C=O)-NH2, NH-(C=O)-NHR6, NR6-(C=O)-NHR6, NH- SO2R6, N(SO2R6)2 y NR6(SO2R6), donde R6 es en cada caso independientemente, un radical cíclico, alquilo C1-8 ciclo(hetero)alquilo C3-8, alquenilo C2-8, ciclo(hetero)alquenilo C3-8, o alquinilo C2-8, cada uno opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, R7, OR7, SR7, NHSO2R7, N(SO2R7) o N(R8)SO2R7, donde R7 es arilo, heteroarilo, arilalquilo C1-5, heteroarilalquilo C1-5, donde arilo es fenilo o naftilo, heteroarilo es un sistema anular heterocíclico aromático de 5 a 5 átomos en el anillo que contiene por lo menos un átomo seleccionado de N, que incluye N-oxido, s y O y donde arilo y heteroarilo están opcionalmente mono- o polisustituidos, con halo, amino, alquilamino C1-3, nitro, alquilo C1-3, O-alquilo C1-3 y/o un radical cíclico y R8 es alquilo C1-5, opcionalmente mono- o polisustituido con halo, OH, O-C1-3 alquilo y/o un radical cíclico, R4 se selecciona de H, halo, un radical cíclico, R9, OH u OR9, NH(C=O)-alquilo C1-3, opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 o/y un radical cíclico, NH2, NHR9 o NR9R10, donde R9 y R10 se seleccionan independientemente de - un radical cíclico, - alquilo C1-6 o ciclo(hetero)alquilo C3-6, opcionalmente mono- o polisustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, - arilalquilo-C1-5, donde arilo es fenilo, opcionalmente mono- o polisustituido con halo, amino, alquilamino C1-3, di-alquilamino C1-3, nitro, alquilo C1-3, O-alquilo C1-3 y/o radical cíclico o -NR9R10 juntos forman un anillo de cinco, seis o siete miembros saturado o insaturado que puede contener hasta 3 heteroátomos, con preferencia N, que incluye N-oxido, Sy/u O, opcionalmente mono- o polisustituido con halo, amino, alquilamino C1-3, di-alquilamino C1-3, nitro, alquilo C1-3, O-alquilo C1-3 y/o aril-alquilo C1-5, donde arilo es fenilo, opcionalmente mono- o polisustituido con halo, amino, alquilamino c1-3, di-alquilamino C1-3, nitro, alquilo C1-3, O-alquilo C1-3 y/o un radical cíclico, y R5 se selecciona de H, alquilo C1-5, cicloalquilo C3-6 o (CO)-alquilo C1-5, opcionalmente mono- o poli sustituido con halo, OH, O-alquilo C1-3 y/o un radical cíclico, o sales y derivados aceptables para uso farmacéutico de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80924206P | 2006-05-30 | 2006-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061206A1 true AR061206A1 (es) | 2008-08-13 |
Family
ID=38441604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102310A AR061206A1 (es) | 2006-05-30 | 2007-05-29 | Pirido[3,2-e]pirazinas, su uso como inhibidores de la fosfodiesterasa 10, y procesos para prepararlas |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7550465B2 (es) |
| EP (1) | EP2021342A1 (es) |
| JP (1) | JP2009538853A (es) |
| KR (1) | KR20090013834A (es) |
| CN (1) | CN101454324A (es) |
| AR (1) | AR061206A1 (es) |
| AU (1) | AU2007267392A1 (es) |
| BR (1) | BRPI0712132A2 (es) |
| CA (1) | CA2651849A1 (es) |
| CL (1) | CL2007001554A1 (es) |
| CR (1) | CR10358A (es) |
| GT (1) | GT200800265A (es) |
| IL (1) | IL193740A0 (es) |
| MX (1) | MX2008014569A (es) |
| NO (1) | NO20085326L (es) |
| PE (1) | PE20080711A1 (es) |
| RU (1) | RU2008152440A (es) |
| SV (1) | SV2009003048A (es) |
| TW (1) | TW200817400A (es) |
| WO (1) | WO2007137820A1 (es) |
| ZA (1) | ZA200807517B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200815436A (en) * | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| ES2536906T3 (es) * | 2006-12-13 | 2015-05-29 | Aska Pharmaceutical Co., Ltd. | Derivado de quinoxalina |
| WO2009070583A1 (en) * | 2007-11-30 | 2009-06-04 | Wyeth | Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10 |
| WO2009068246A2 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Methods of treating obesity and metabolic disorders |
| CA2706866A1 (en) * | 2007-11-30 | 2009-06-04 | Biotie Therapies Gmbh | Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10 |
| BRPI0912223A2 (pt) * | 2008-05-07 | 2015-10-06 | Lundbeck & Co As H | métodos para melhorar funcionamento cognitivo e para tratar uma doença, composto, uso do mesmo, e, composição farmacêutica. |
| WO2010054253A1 (en) * | 2008-11-07 | 2010-05-14 | Biotie Therapies Gmbh | Triazine derivatives as inhibitors of phosphodiesterases |
| HUE058736T2 (hu) * | 2010-07-20 | 2022-09-28 | Minerva Neurosciences Inc | Gyûrûs amidszármazékok alkalmazási módszerei szigma receptor közvetített rendellenességek kezelésére |
| FI3135286T3 (fi) * | 2010-07-20 | 2023-11-15 | Minerva Neurosciences Inc | Menetelmiä syklisten amidijohdannaisten käyttämiseksi skitsofrenian ja sen oireiden hoitamisessa |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| US8772316B2 (en) | 2011-02-18 | 2014-07-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A) |
| US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| JP2014526453A (ja) * | 2011-09-09 | 2014-10-06 | ハー・ルンドベック・アクチエゼルスカベット | ピリジン化合物およびそれらの使用 |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| CN104203919A (zh) | 2011-11-09 | 2014-12-10 | 艾伯维德国有限责任两合公司 | 可用作10a型磷酸二酯酶的抑制剂的杂环甲酰胺类 |
| KR20150005936A (ko) | 2012-04-25 | 2015-01-15 | 다케다 야쿠힌 고교 가부시키가이샤 | 질소화 헤테로시클릭 화합물 |
| EP2873669A4 (en) * | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND |
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| US9464085B2 (en) | 2012-08-17 | 2016-10-11 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| AU2013314244A1 (en) | 2012-09-17 | 2015-03-12 | AbbVie Deutschland GmbH & Co. KG | Novel inhibitor compounds of phosphodiesterase type 10A |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9790203B2 (en) | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| US9200005B2 (en) | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9163019B2 (en) | 2013-03-14 | 2015-10-20 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| JP6427491B2 (ja) | 2013-07-03 | 2018-11-21 | 武田薬品工業株式会社 | 複素環化合物 |
| ES2950424T3 (es) | 2013-07-03 | 2023-10-09 | Takeda Pharmaceuticals Co | Compuesto de amida |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| EP3856185A1 (en) | 2018-09-28 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| CN114524808B (zh) * | 2022-02-21 | 2023-10-24 | 深圳市儿童医院 | 一种吡唑衍生物及其作为pde10抑制剂的用途 |
| CN114524806A (zh) * | 2022-02-22 | 2022-05-24 | 深圳市儿童医院 | 一种三氮唑衍生物及其作为pde10抑制剂的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
| EP0590022A1 (en) * | 1991-06-14 | 1994-04-06 | PHARMACIA & UPJOHN COMPANY | IMIDAZO 1,5-a]QUINOXALINES |
| DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
-
2007
- 2007-05-18 TW TW096117906A patent/TW200817400A/zh unknown
- 2007-05-24 US US11/753,207 patent/US7550465B2/en not_active Expired - Fee Related
- 2007-05-29 JP JP2009512482A patent/JP2009538853A/ja active Pending
- 2007-05-29 MX MX2008014569A patent/MX2008014569A/es active IP Right Grant
- 2007-05-29 AU AU2007267392A patent/AU2007267392A1/en not_active Abandoned
- 2007-05-29 RU RU2008152440/04A patent/RU2008152440A/ru not_active Application Discontinuation
- 2007-05-29 CN CNA2007800193040A patent/CN101454324A/zh active Pending
- 2007-05-29 EP EP07725639A patent/EP2021342A1/en not_active Withdrawn
- 2007-05-29 BR BRPI0712132-6A patent/BRPI0712132A2/pt not_active IP Right Cessation
- 2007-05-29 AR ARP070102310A patent/AR061206A1/es unknown
- 2007-05-29 CA CA002651849A patent/CA2651849A1/en not_active Abandoned
- 2007-05-29 KR KR1020087031860A patent/KR20090013834A/ko not_active Application Discontinuation
- 2007-05-29 WO PCT/EP2007/004748 patent/WO2007137820A1/en active Application Filing
- 2007-05-30 PE PE2007000674A patent/PE20080711A1/es not_active Application Discontinuation
- 2007-05-30 CL CL2007001554A patent/CL2007001554A1/es unknown
-
2008
- 2008-08-28 IL IL193740A patent/IL193740A0/en unknown
- 2008-08-29 ZA ZA200807517A patent/ZA200807517B/xx unknown
- 2008-10-02 SV SV2008003048A patent/SV2009003048A/es active IP Right Grant
- 2008-10-10 CR CR10358A patent/CR10358A/es not_active Application Discontinuation
- 2008-11-27 GT GT200800265A patent/GT200800265A/es unknown
- 2008-12-19 NO NO20085326A patent/NO20085326L/no not_active Application Discontinuation
-
2009
- 2009-05-19 US US12/454,537 patent/US20090239874A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20085326L (no) | 2008-12-19 |
| SV2009003048A (es) | 2009-02-11 |
| CL2007001554A1 (es) | 2008-01-18 |
| TW200817400A (en) | 2008-04-16 |
| US20080027064A1 (en) | 2008-01-31 |
| GT200800265A (es) | 2010-07-22 |
| EP2021342A1 (en) | 2009-02-11 |
| ZA200807517B (en) | 2009-06-24 |
| CN101454324A (zh) | 2009-06-10 |
| US7550465B2 (en) | 2009-06-23 |
| RU2008152440A (ru) | 2010-07-10 |
| CR10358A (es) | 2009-01-07 |
| IL193740A0 (en) | 2009-05-04 |
| WO2007137820A1 (en) | 2007-12-06 |
| US20090239874A1 (en) | 2009-09-24 |
| KR20090013834A (ko) | 2009-02-05 |
| PE20080711A1 (es) | 2008-06-14 |
| AU2007267392A1 (en) | 2007-12-06 |
| JP2009538853A (ja) | 2009-11-12 |
| BRPI0712132A2 (pt) | 2012-01-17 |
| CA2651849A1 (en) | 2007-12-06 |
| MX2008014569A (es) | 2008-12-03 |
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