AR058210A1 - Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores. - Google Patents

Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores.

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Publication number
AR058210A1
AR058210A1 ARP060105089A ARP060105089A AR058210A1 AR 058210 A1 AR058210 A1 AR 058210A1 AR P060105089 A ARP060105089 A AR P060105089A AR P060105089 A ARP060105089 A AR P060105089A AR 058210 A1 AR058210 A1 AR 058210A1
Authority
AR
Argentina
Prior art keywords
amino
formula
thiazolo
pyrimidin
tiazolo
Prior art date
Application number
ARP060105089A
Other languages
English (en)
Inventor
T Wang
J S Ng
S E Webber
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of AR058210A1 publication Critical patent/AR058210A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicacion 1: Un procedimiento para la preparacion de 5-amino-3H-tiazolo[4,5-d]pirimidin-2-ona que posee la formula (1) caracterizado porque comprende: (i) halogenacion de una 2,4-diaminopirimidina de formula (2) para formar un 2,4-diamino-5- halo-pirimidina de formula (3) en donde X representa halo seleccionado de F, Cl, Br e I; (ii) ciclocondensacion de 2,4-diamino-5-halo-pirimidina para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4); y (iii) oxidar la 5-amino-3H- tiazolo[4,5-d]pirimidin-2-tiona para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-ona. Reivindicacion 12: Un procedimiento para la ciclocondensacion de 2,4-diamino-5-halo-pirimidina de formula (3) caracterizado porque X es halo seleccionado de F, Cl, Br, e I; para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4) en donde la ciclocondensacion es realizada en presencia de un compuesto xantogenato que tiene la formula (5) en donde M es un cation de metal y R1es un grupo alquilo; y en donde la reaccion comprende calentar la solucion e los reactivos anteriores en presencia de un solvente inerte. Reivindicacion 17: Un procedimiento para oxidar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4) para formar 5-amino-3- tiazolo[4,5-d]pirimidin-2-ona de formula (1) en donde el procedimiento comprende: hacer reaccionar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona con un agente oxidante bajo condiciones básicas y una hidrolisis ácida subsiguiente.
ARP060105089A 2005-11-21 2006-11-21 Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores. AR058210A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73805505P 2005-11-21 2005-11-21

Publications (1)

Publication Number Publication Date
AR058210A1 true AR058210A1 (es) 2008-01-23

Family

ID=37908057

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105089A AR058210A1 (es) 2005-11-21 2006-11-21 Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores.

Country Status (18)

Country Link
US (1) US7781581B2 (es)
EP (1) EP1973920B1 (es)
JP (1) JP5117391B2 (es)
KR (1) KR20080090400A (es)
CN (1) CN101365705A (es)
AR (1) AR058210A1 (es)
AT (1) ATE474842T1 (es)
AU (1) AU2006318260B2 (es)
BR (1) BRPI0618789A2 (es)
CA (1) CA2630463C (es)
DE (1) DE602006015700D1 (es)
EA (1) EA200801404A1 (es)
ES (1) ES2345904T3 (es)
IL (1) IL191568A0 (es)
NO (1) NO20082365L (es)
SG (1) SG152296A1 (es)
TW (1) TWI383987B (es)
WO (1) WO2007062355A2 (es)

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JPWO2012102366A1 (ja) * 2011-01-28 2014-06-30 日本たばこ産業株式会社 新規ピペラジン化合物の製造方法
CN103012284A (zh) * 2012-12-26 2013-04-03 无锡捷化医药科技有限公司 一种2-氨基-5-溴嘧啶类化合物的制备方法
JP6817217B2 (ja) 2014-12-08 2021-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ウイルス感染症の治療および予防のための３−置換された５−アミノ−６Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン化合物
JP7201598B2 (ja) 2017-01-06 2023-01-10 エフ．ホフマン－ラ ロシュ アーゲー ３位置換５－アミノ－６Ｈ－チアゾロ［４，５－ｄ］ピリミジン－２，７－ジオン化合物の製造法
CN111635368B (zh) * 2020-06-12 2021-06-29 东莞市东阳光仿制药研发有限公司 一种胺化合物的制备方法

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Also Published As

Publication number Publication date
WO2007062355A2 (en) 2007-05-31
ATE474842T1 (de) 2010-08-15
AU2006318260B2 (en) 2012-05-17
AU2006318260A1 (en) 2007-05-31
US20070117979A1 (en) 2007-05-24
TW200736265A (en) 2007-10-01
EP1973920A2 (en) 2008-10-01
KR20080090400A (ko) 2008-10-08
DE602006015700D1 (de) 2010-09-02
JP5117391B2 (ja) 2013-01-16
CN101365705A (zh) 2009-02-11
ES2345904T3 (es) 2010-10-05
BRPI0618789A2 (pt) 2016-08-30
IL191568A0 (en) 2008-12-29
CA2630463A1 (en) 2007-05-31
NO20082365L (no) 2008-08-18
EA200801404A1 (ru) 2008-10-30
JP2009516709A (ja) 2009-04-23
CA2630463C (en) 2015-01-06
EP1973920B1 (en) 2010-07-21
US7781581B2 (en) 2010-08-24
WO2007062355A3 (en) 2007-07-26
TWI383987B (zh) 2013-02-01
SG152296A1 (en) 2009-05-29

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