AR054726A1 - 2- fenil- indoles como antagonistas del receptor de la prostaglandina d2 - Google Patents
2- fenil- indoles como antagonistas del receptor de la prostaglandina d2Info
- Publication number
- AR054726A1 AR054726A1 ARP060100278A ARP060100278A AR054726A1 AR 054726 A1 AR054726 A1 AR 054726A1 AR P060100278 A ARP060100278 A AR P060100278A AR P060100278 A ARP060100278 A AR P060100278A AR 054726 A1 AR054726 A1 AR 054726A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkynyl
- alkenyl
- alkyl
- optionally substituted
- substituent groups
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a una de sus sales, hidratos o solvatos farmacéuticamente aceptables, uno de sus profármacos farmacéuticamente aceptables, o una sal, hidrato o solvato del profármaco farmacéuticamente aceptable, una composicion farmacéutica que comprende una cantidad terapéuticamente eficaz de uno o más compuestos segun al formula (1), en mezcla con un vehículo farmacéuticamente aceptable, un método para tratar a un paciente que sufre un trastorno mediado por la PGD2 incluyendo, pero sin limitarse a ellas, enfermedades alérgicas (tales como rinitis alérgica, conjuntivitis alérgica, dermatitis atopica, asma bronquial y alergia a los alimentos), mastocitosis sistémica, trastornos acompanados de la activacion sistemática de los mastocitos, shock anafiláctico, broncoconstriccion, bronquitis, urticaria, eczema, enfermedades acompanadas de prurito (tales como dermatitis atopica y urticaria), enfermedades (tales como cataratas, desprendimiento de retina, inflamacion, infeccion y trastornos del sueno) que se generan de forma secundaria como resultado de la conducta acompanadas de prurito (tales como escarificaciones y contusiones), inflamacion, enfermedades pulmonares obstructivas cronicas, lesiones por reperfusion isquémica, accidente cerebrovascular, artritis reumatoide cronica, pleuresía, colitis ulcerosa y similares, administrando a dicho paciente una cantidad terapéuticamente eficaz de un compuesto segun la formula (1). Reivindicacion 1: Un compuesto de la formula (1), en la que: R es R1SO2-, R1SO-, R1S-, -R1CO-, R8-C(=O)-NH-, o R8-SO2-NH-; R1 es alquilo, alquenilo, o alquinilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos; cicloalquilo, cicloalquenilo, arilo, heteroarilo, heterociclilo, heterociclenilo, o alcarilo multicíclico, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes anulares; o -NR'R'' cuando R es R1SO2- o R1CO-; R' es hidrogeno; arilo, heteroarilo, cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo, o alcarilo multicíclico, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes anulares; o alquilo, alquenilo o alquinilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos; R'' es hidrogeno, alquilo, alquenilo o alquinilo; R2 es hidrogeno, halo, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, haloalquinilo, alcoxi, alqueniloxi o alquiniloxi; R3 es acilo, ciano, carboxi, ácido bioisostero, -C(O)-NY1Y2; aroilo o heteroarilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes anulares; alquilo, alquenilo o alquinilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos; o alcoxi, alqueniloxi o alquiniloxi, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos; Y1 e Y2 son cada uno independientemente hidrogeno, alquilsulfonilo, arilsulfonilo, arilamino, heteroarilsulfonilo, heteroarilamino; o alquilo, alquenilo o alquinilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos, R4 es hidrogeno, acilo, aroilo, heteroarilo, alquilsulfonilo, arilsulfonilo, arilalquilsulfonilo heteroarilsulfonilo, heteroarilalquilsulfonilo, -C(O)-NY4Y5, -C(O)-O-Y6; alquilo, alquenilo o alquinilo, cada uno de los cuales está opcionalmente sustituido con arilo, heteroarilo, carboxi, alcoxicarbonilo, aminocarbonilo, alquilaminocarbonilo, dialquilaminocarbonilo, aroilo, heteroaroilo o acilo; o alquilo C2-6, alquenilo o alquinilo, cada uno de los cuales está sustituido con halo, hidroxi, alcoxi, amino, alquilamino o dialquilamino; Y4 e Y5 son cada uno independientemente hidrogeno, alquilo, alquenilo o alquinilo; Y6 es alquilo, alquenilo o alquinilo; R5 es hidrogeno, halo, carboxi, ciano, nitro, hidroxi, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, haloalquinilo, alcoxi, alqueniloxi, alquiniloxi, haloalcoxi, haloalqueniloxi o haloalquiniloxi; R6 y R7 son cada uno independientemente, hidrogeno, alquilo, alquenilo o alquinilo; o R8 es alquilo, alquenilo, o alquinilo, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes alifáticos; o arilo, heteroarilo, cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo, o alcarilo multicíclico, cada uno de los cuales está opcionalmente sustituido con uno o más grupos sustituyentes anulares; y n es 1 a 6, o 0 cuando R3 es carboxi, ácido bioisostero, o -C(O)-NY1Y2; con la condicion de que cuando R1 es amino, entonces R4 es hidrogeno y n es 1 a 6; o una de sus sales, hidratos o solvatos farmacéuticamente aceptables, uno de sus profármacos farmacéuticamente aceptables, o una sal, hidrato o solvato del profármaco farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64730705P | 2005-01-26 | 2005-01-26 |
Publications (1)
Publication Number | Publication Date |
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AR054726A1 true AR054726A1 (es) | 2007-07-11 |
Family
ID=36282872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100278A AR054726A1 (es) | 2005-01-26 | 2006-01-25 | 2- fenil- indoles como antagonistas del receptor de la prostaglandina d2 |
Country Status (25)
Country | Link |
---|---|
US (1) | US20070265278A1 (es) |
EP (1) | EP1844011A1 (es) |
JP (1) | JP2008528606A (es) |
KR (1) | KR20070110277A (es) |
CN (1) | CN101146770A (es) |
AR (1) | AR054726A1 (es) |
AU (1) | AU2006209213A1 (es) |
BR (1) | BRPI0607079A2 (es) |
CA (1) | CA2595728A1 (es) |
CR (1) | CR9214A (es) |
DO (1) | DOP2006000016A (es) |
GT (1) | GT200600030A (es) |
IL (1) | IL184816A0 (es) |
MA (1) | MA29259B1 (es) |
MX (1) | MX2007008277A (es) |
NO (1) | NO20074336L (es) |
PA (1) | PA8661201A1 (es) |
PE (1) | PE20060878A1 (es) |
RU (1) | RU2007132166A (es) |
SG (1) | SG158918A1 (es) |
TN (1) | TNSN07251A1 (es) |
TW (1) | TW200639151A (es) |
UY (1) | UY29346A1 (es) |
WO (1) | WO2006081343A1 (es) |
ZA (1) | ZA200705449B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2659055A1 (en) * | 2006-07-25 | 2008-01-31 | Sanofi-Aventis | 2-phenyl-indoles as prostaglandin d2 receptor antagonists |
ES2374321T3 (es) | 2006-08-07 | 2012-02-15 | Actelion Pharmaceuticals Ltd. | Derivados del ácido (3-amino-1,2,3,4-tetrahidro-9h-carbazol-9-il)-acético. |
WO2008061006A1 (en) * | 2006-11-10 | 2008-05-22 | Wyeth | Substituted indan-2-yl, tetrahydronaphthalen-2-yl, or dihydr0-2h-chr0men-3-yl arylsulfonamides and methods of their use |
WO2009061730A2 (en) * | 2007-11-05 | 2009-05-14 | Array Biopharma Inc. | 4-heteroaryl-substituted phenoxyphenylacetic acid |
RU2562255C2 (ru) | 2010-03-22 | 2015-09-10 | Актелион Фармасьютиклз Лтд | Производные 3-(гетероариламино)-1,2,3,4-тетрагидро-9н-карбазола и их применение в качестве модуляторов рецепторов простагландина d2 |
US8722719B2 (en) * | 2010-10-06 | 2014-05-13 | Kureha Corporation | Amine compound and use for same |
KR101928595B1 (ko) | 2011-04-14 | 2018-12-12 | 이도르시아 파마슈티컬스 리미티드 | 7-(헤테로아릴-아미노)-6,7,8,9-테트라히드로피리도[1,2-a]인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절자로서의 이의 용도 |
EP2548863A1 (en) * | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
EP2762141A4 (en) * | 2011-09-29 | 2015-03-25 | Shionogi & Co | THERAPEUTIC PHARMACEUTICAL PRODUCT AGAINST ALLERGIC RHINITIS COMPRISING A PGD2 ANTAGONIST AND A HISTAMINE ANTAGONIST |
KR20140107550A (ko) | 2011-12-21 | 2014-09-04 | 액테리온 파마슈티칼 리미티드 | 헤테로시클릴 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 그의 용도 |
JP6127135B2 (ja) | 2012-07-05 | 2017-05-10 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 1−フェニル置換ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
EP3382391A1 (en) | 2012-10-24 | 2018-10-03 | NYU Winthrop Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
JP6168520B2 (ja) * | 2013-09-17 | 2017-07-26 | 国立大学法人 千葉大学 | インドール化合物、dpプロスタノイド受容体アンタゴニスト、それを用いた薬剤、及びdpプロスタノイド受容体アンタゴニストの使用。 |
JP2015089886A (ja) * | 2013-11-06 | 2015-05-11 | 国立大学法人名古屋大学 | 嵩高い置換基を有する化合物を用いた植物成長調整剤 |
HUE039614T2 (hu) | 2014-03-17 | 2019-01-28 | Idorsia Pharmaceuticals Ltd | Azaindol-ecetsav-származékok és prosztaglandin D2 receptor modulátorokként történõ alkalmazásuk |
CA2938107A1 (en) | 2014-03-18 | 2015-09-24 | Actelion Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
UA123156C2 (uk) | 2015-09-15 | 2021-02-24 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА ФОРМА (S)-2-(8-((5-ХЛОРПІРИМІДИН-2-ІЛ)(МЕТИЛ)АМІНО)-2-ФТОР-6,7,8,9-ТЕТРАГІДРО-5H-ПІРИДО[3,2-b]ІНДОЛ-5-ІЛ)ОЦТОВОЇ КИСЛОТИ, ЇЇ ЗАСТОСУВАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ |
MX2020002788A (es) | 2017-09-13 | 2020-09-14 | Progenity Inc | Biomarcadores de preeclampsia y sistemas y metodos relacionados. |
EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
CN113173877B (zh) * | 2020-10-30 | 2023-10-27 | 江西师范大学 | 吲哚乙酰基亚氨基砜系列化合物及其制备方法 |
CN115925606B (zh) * | 2023-01-05 | 2023-10-13 | 宁夏医科大学 | 一种5-(3-(磺酰胺基)苯基)-1h-吡咯-2-羧酸衍生物及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR950701317A (ko) * | 1992-05-08 | 1995-03-23 | 오오쓰까 아끼히꼬 | 인돌 유도체(Indole Derivative) |
FR2751966B1 (fr) * | 1996-08-01 | 1998-10-30 | Union Pharma Scient Appl | Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique |
US6500853B1 (en) * | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
JP2004024655A (ja) * | 2002-06-27 | 2004-01-29 | Aruze Corp | 遊技機 |
EP1600440A1 (en) * | 2003-03-06 | 2005-11-30 | Ono Pharmaceutical Co., Ltd. | Indole derivative compounds and drugs containing the compounds as the active ingredient |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
US8013006B2 (en) * | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) * | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
-
2006
- 2006-01-20 DO DO2006000016A patent/DOP2006000016A/es unknown
- 2006-01-24 PE PE2006000105A patent/PE20060878A1/es not_active Application Discontinuation
- 2006-01-25 JP JP2007553221A patent/JP2008528606A/ja active Pending
- 2006-01-25 KR KR1020077017292A patent/KR20070110277A/ko not_active Application Discontinuation
- 2006-01-25 EP EP06719551A patent/EP1844011A1/en not_active Withdrawn
- 2006-01-25 AU AU2006209213A patent/AU2006209213A1/en not_active Abandoned
- 2006-01-25 WO PCT/US2006/002736 patent/WO2006081343A1/en active Application Filing
- 2006-01-25 CN CNA2006800097886A patent/CN101146770A/zh active Pending
- 2006-01-25 SG SG201000540-3A patent/SG158918A1/en unknown
- 2006-01-25 CA CA002595728A patent/CA2595728A1/en not_active Abandoned
- 2006-01-25 BR BRPI0607079-5A patent/BRPI0607079A2/pt not_active IP Right Cessation
- 2006-01-25 MX MX2007008277A patent/MX2007008277A/es not_active Application Discontinuation
- 2006-01-25 GT GT200600030A patent/GT200600030A/es unknown
- 2006-01-25 RU RU2007132166/04A patent/RU2007132166A/ru not_active Application Discontinuation
- 2006-01-25 AR ARP060100278A patent/AR054726A1/es not_active Application Discontinuation
- 2006-01-26 UY UY29346A patent/UY29346A1/es unknown
- 2006-01-26 PA PA20068661201A patent/PA8661201A1/es unknown
- 2006-01-26 TW TW095102967A patent/TW200639151A/zh unknown
-
2007
- 2007-06-28 CR CR9214A patent/CR9214A/es not_active Application Discontinuation
- 2007-07-03 TN TNP2007000251A patent/TNSN07251A1/en unknown
- 2007-07-04 ZA ZA200705449A patent/ZA200705449B/xx unknown
- 2007-07-24 IL IL184816A patent/IL184816A0/en unknown
- 2007-07-25 US US11/782,890 patent/US20070265278A1/en not_active Abandoned
- 2007-08-17 MA MA30150A patent/MA29259B1/fr unknown
- 2007-08-24 NO NO20074336A patent/NO20074336L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200639151A (en) | 2006-11-16 |
WO2006081343A1 (en) | 2006-08-03 |
PE20060878A1 (es) | 2006-10-18 |
CR9214A (es) | 2007-11-23 |
EP1844011A1 (en) | 2007-10-17 |
JP2008528606A (ja) | 2008-07-31 |
AU2006209213A1 (en) | 2006-08-03 |
KR20070110277A (ko) | 2007-11-16 |
TNSN07251A1 (en) | 2008-12-31 |
GT200600030A (es) | 2006-09-27 |
US20070265278A1 (en) | 2007-11-15 |
CN101146770A (zh) | 2008-03-19 |
IL184816A0 (en) | 2007-12-03 |
DOP2006000016A (es) | 2006-07-31 |
NO20074336L (no) | 2007-10-23 |
RU2007132166A (ru) | 2009-03-10 |
CA2595728A1 (en) | 2006-08-03 |
UY29346A1 (es) | 2006-08-31 |
MA29259B1 (fr) | 2008-02-01 |
BRPI0607079A2 (pt) | 2009-08-04 |
SG158918A1 (en) | 2010-02-26 |
ZA200705449B (en) | 2009-01-28 |
PA8661201A1 (es) | 2006-09-08 |
MX2007008277A (es) | 2007-09-07 |
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