AR053237A1 - Proceso para la preparacion de quetiapina y fumarato de quetiapina - Google Patents
Proceso para la preparacion de quetiapina y fumarato de quetiapinaInfo
- Publication number
- AR053237A1 AR053237A1 ARP060101584A ARP060101584A AR053237A1 AR 053237 A1 AR053237 A1 AR 053237A1 AR P060101584 A ARP060101584 A AR P060101584A AR P060101584 A ARP060101584 A AR P060101584A AR 053237 A1 AR053237 A1 AR 053237A1
- Authority
- AR
- Argentina
- Prior art keywords
- quetiapine
- dibenzo
- fumarate
- thiazepine
- chloro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Proceso para preparar quetiapina y/o sus sales, incluyendo fumarato de quetiapina. En general, el proceso comprende hacer reaccionar dibenzotiazepinona (dibenzo [b,f][1,4]tiazepin-11(10H)-ona) con oxicloruro fosforoso en presencia de trietilamina en un solvente orgánico aromático tal como tolueno o preferentemente, xileno a temperatura de reflujo para obtener una solucion de hidrocarburo aromático de 11-cloro-dibenzo[b,f][1,4]tiazepina. Luego de eso, la 11-cloro-dibenzo[b,f][1,4]tiazepina se hace reaccionar con 2-(2-piperazin-1-iletoxi)etanol para producir quetiapina luego de seguir varios pasos de tratamiento. Entonces, el compuesto 1 se puede hacer seguir reaccionando con ácido fumárico a una temperatura elevada para producir fumarato de quetiapina. El fumarato de quetiapina resultante obtenido es apropiado para utilizar en reparados farmacéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67337305P | 2005-04-21 | 2005-04-21 | |
US73086405P | 2005-10-28 | 2005-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053237A1 true AR053237A1 (es) | 2007-04-25 |
Family
ID=37308368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101584A AR053237A1 (es) | 2005-04-21 | 2006-04-21 | Proceso para la preparacion de quetiapina y fumarato de quetiapina |
Country Status (5)
Country | Link |
---|---|
US (1) | US8048876B2 (es) |
EP (1) | EP1879874A2 (es) |
AR (1) | AR053237A1 (es) |
CA (1) | CA2605473C (es) |
WO (1) | WO2006117700A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006113425A1 (en) | 2005-04-14 | 2006-10-26 | Teva Pharmaceutical Industries Ltd. | Process for preparing quetiapine fumarate |
HU230144B1 (hu) * | 2007-06-12 | 2015-09-28 | Richter Gedeon Nyrt. | Eljárás quetiapin előállítására |
JP5343362B2 (ja) * | 2008-01-23 | 2013-11-13 | 住友化学株式会社 | ビス{2−〔2−(4−ジベンゾ〔b,f〕〔1,4〕チアゼピン−11−イル−1−ピペラジニル)エトキシ〕エタノール}モノフマレートの製造方法 |
CA2711395A1 (en) * | 2008-01-31 | 2009-08-06 | Fermion Oy | A process for the preparation of quetiapine |
EP2268283A2 (en) * | 2008-03-12 | 2011-01-05 | Dexcel Ltd. | Oral modified-release formulations containing thiazepines |
EP2153834A3 (en) * | 2008-08-07 | 2010-02-24 | Farmaprojects, S.A. | Extended release pharmaceutical compositions comprising quetiapine salts |
JP2010053044A (ja) * | 2008-08-26 | 2010-03-11 | Sumitomo Chemical Co Ltd | 11−クロロジベンゾ〔b,f〕〔1,4〕チアゼピンの製造方法 |
WO2010070510A2 (en) * | 2008-12-15 | 2010-06-24 | Alembic Limited | A process for preparing quetiapine fumarate |
JP2012519683A (ja) | 2009-03-04 | 2012-08-30 | ランバクシー ラボラトリーズ リミテッド | フマル酸クエチアピンの調製方法 |
CN101940561A (zh) * | 2010-09-14 | 2011-01-12 | 浙江华海药业股份有限公司 | 喹硫平片及其制备方法 |
CN108586385B (zh) * | 2017-12-26 | 2020-03-20 | 山东安信制药有限公司 | 一种制备大粒度富马酸喹硫平的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
US5286722A (en) * | 1990-07-24 | 1994-02-15 | Akzo N.V. | Tetrahydropyridinyldibenzazepine derivatives |
GB9922271D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Formulation |
CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
JP3624954B1 (ja) * | 2001-11-07 | 2005-03-02 | 藤沢薬品工業株式会社 | 分散不良薬物の溶出性を改善する方法 |
AU2003235435A1 (en) | 2002-03-20 | 2003-10-08 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of quetiapine hemifumarate |
WO2004078735A1 (en) | 2003-03-03 | 2004-09-16 | Hetero Drugs Limited | Novel polymorphs of quetiapine fumarate |
KR101038389B1 (ko) | 2004-06-23 | 2011-06-01 | 에스케이바이오팜 주식회사 | 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[b,f][1,4]티아제핀의 제조방법 |
US20060063927A1 (en) | 2004-09-22 | 2006-03-23 | Olga Etlin | Processes for preparing quetiapine and salts thereof |
-
2006
- 2006-04-21 WO PCT/IB2006/002286 patent/WO2006117700A2/en active Application Filing
- 2006-04-21 EP EP06765649A patent/EP1879874A2/en not_active Ceased
- 2006-04-21 AR ARP060101584A patent/AR053237A1/es not_active Application Discontinuation
- 2006-04-21 CA CA2605473A patent/CA2605473C/en not_active Expired - Fee Related
- 2006-04-21 US US11/911,898 patent/US8048876B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2605473C (en) | 2013-10-29 |
CA2605473A1 (en) | 2006-11-09 |
US20090076262A1 (en) | 2009-03-19 |
WO2006117700A3 (en) | 2007-03-01 |
WO2006117700A2 (en) | 2006-11-09 |
EP1879874A2 (en) | 2008-01-23 |
US8048876B2 (en) | 2011-11-01 |
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