AR052669A1 - Esteres de acido de acido propano - fosfinico sustituido; composiciones farmaceuticas que los contienen y su uso para el tratamiento de trastornos psiquiatricos. - Google Patents
Esteres de acido de acido propano - fosfinico sustituido; composiciones farmaceuticas que los contienen y su uso para el tratamiento de trastornos psiquiatricos.Info
- Publication number
- AR052669A1 AR052669A1 ARP060100484A ARP060100484A AR052669A1 AR 052669 A1 AR052669 A1 AR 052669A1 AR P060100484 A ARP060100484 A AR P060100484A AR P060100484 A ARP060100484 A AR P060100484A AR 052669 A1 AR052669 A1 AR 052669A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- acid
- pharmaceutical compositions
- aryl
- esteres
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 title 2
- 239000002253 acid Substances 0.000 title 2
- 239000001294 propane Substances 0.000 title 1
- 208000020016 psychiatric disease Diseases 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical group NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 abstract 1
- 206010037180 Psychiatric symptoms Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- -1 enantiomers Chemical class 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Estos compuestos son utiles para tratar una variedad de enfermedades que incluyen, pero no están limitadas a, la depresion ansiedad, determinados síntomas psiquiátricos, deterioro cognitivo y esquizofrenia, y son utilizados para la preparacion de composiciones farmacéuticas. Reivindicacion 1: Un compuesto, incluyendo enantiomeros, estereoisomeros y tautomeros de dicho compuesto y sus sales, solvatos o derivados farmacéuticamente aceptables, teniendo dicho compuesto la estructura general mostrada en la formula (1) en la que: R es alquilo C1-8, cicloalquil C3-8-alquilo C1-4, aril-alquilo C1-4 o fluoro-alquilo de la formula CnHxFy, en la que n es un numero entero de 1 a 4, x es un numero entero de 0 a 8, y es un numero entero de 1 a 9, y la suma de x e y es 2n+1; R1 es H o hidroxi; R2 es arilo sustituido o sin sustituir, aril-alquilo C1-4, heteroarilo o heteroarilalquilo, o CHWOCOX: en la que W es H o alquilo C1-4; X es alquilo C1-4, cicloalquilo C3-8, arilo, heteroarilo, NHY o OY; y en la que Y es alquilo C1-4, cicloalquilo C3-8, arilo o heteroarilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65215205P | 2005-02-11 | 2005-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052669A1 true AR052669A1 (es) | 2007-03-28 |
Family
ID=36283910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100484A AR052669A1 (es) | 2005-02-11 | 2006-02-10 | Esteres de acido de acido propano - fosfinico sustituido; composiciones farmaceuticas que los contienen y su uso para el tratamiento de trastornos psiquiatricos. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7687540B2 (es) |
| EP (1) | EP1851234B1 (es) |
| JP (1) | JP2008530125A (es) |
| KR (1) | KR20070101322A (es) |
| CN (1) | CN101155818A (es) |
| AR (1) | AR052669A1 (es) |
| AT (1) | ATE420094T1 (es) |
| AU (1) | AU2006213663A1 (es) |
| BR (1) | BRPI0608238A2 (es) |
| CA (1) | CA2597408A1 (es) |
| DE (1) | DE602006004706D1 (es) |
| ES (1) | ES2318731T3 (es) |
| IL (1) | IL185172A0 (es) |
| MA (1) | MA29287B1 (es) |
| MX (1) | MX2007008392A (es) |
| NO (1) | NO20074569L (es) |
| RU (1) | RU2007133791A (es) |
| WO (1) | WO2006086734A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4555579A (en) * | 1983-03-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors |
| US5190933A (en) | 1987-12-04 | 1993-03-02 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| GB8728483D0 (en) * | 1987-12-04 | 1988-01-13 | Ciba Geigy Ag | Chemical compounds |
| US5300679A (en) | 1987-12-04 | 1994-04-05 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| EP0767174A1 (de) * | 1991-11-21 | 1997-04-09 | Ciba-Geigy Ag | Neue Aminoalkanphosphinsäuren und ihre Salze |
| IS1935B (is) * | 2002-03-19 | 2004-06-16 | Actavis Group Hf. | Fósínópríl lyfjasamsetning |
-
2006
- 2006-02-10 CA CA002597408A patent/CA2597408A1/en not_active Abandoned
- 2006-02-10 JP JP2007555299A patent/JP2008530125A/ja active Pending
- 2006-02-10 BR BRPI0608238-6A patent/BRPI0608238A2/pt not_active Application Discontinuation
- 2006-02-10 EP EP06720666A patent/EP1851234B1/en active Active
- 2006-02-10 AR ARP060100484A patent/AR052669A1/es not_active Application Discontinuation
- 2006-02-10 CN CNA2006800116232A patent/CN101155818A/zh active Pending
- 2006-02-10 WO PCT/US2006/004938 patent/WO2006086734A1/en active Application Filing
- 2006-02-10 AU AU2006213663A patent/AU2006213663A1/en not_active Abandoned
- 2006-02-10 DE DE602006004706T patent/DE602006004706D1/de not_active Expired - Fee Related
- 2006-02-10 KR KR1020077018417A patent/KR20070101322A/ko not_active Application Discontinuation
- 2006-02-10 ES ES06720666T patent/ES2318731T3/es active Active
- 2006-02-10 RU RU2007133791/04A patent/RU2007133791A/ru not_active Application Discontinuation
- 2006-02-10 MX MX2007008392A patent/MX2007008392A/es unknown
- 2006-02-10 AT AT06720666T patent/ATE420094T1/de not_active IP Right Cessation
-
2007
- 2007-07-10 US US11/775,547 patent/US7687540B2/en not_active Expired - Fee Related
- 2007-08-09 IL IL185172A patent/IL185172A0/en unknown
- 2007-08-31 MA MA30188A patent/MA29287B1/fr unknown
- 2007-09-10 NO NO20074569A patent/NO20074569L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE420094T1 (de) | 2009-01-15 |
| MA29287B1 (fr) | 2008-02-01 |
| KR20070101322A (ko) | 2007-10-16 |
| ES2318731T3 (es) | 2009-05-01 |
| CA2597408A1 (en) | 2006-08-17 |
| US7687540B2 (en) | 2010-03-30 |
| RU2007133791A (ru) | 2009-03-20 |
| EP1851234A1 (en) | 2007-11-07 |
| JP2008530125A (ja) | 2008-08-07 |
| IL185172A0 (en) | 2007-12-03 |
| DE602006004706D1 (de) | 2009-02-26 |
| US20070270385A1 (en) | 2007-11-22 |
| EP1851234B1 (en) | 2009-01-07 |
| AU2006213663A1 (en) | 2006-08-17 |
| CN101155818A (zh) | 2008-04-02 |
| NO20074569L (no) | 2007-11-07 |
| WO2006086734A1 (en) | 2006-08-17 |
| MX2007008392A (es) | 2007-09-06 |
| BRPI0608238A2 (pt) | 2009-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR016307A1 (es) | Imidazopirimidinas e imidazopiridinas, metodo para el tratamiento de afecciones neurologicas, y composicion farmaceutica. | |
| ECSP066667A (es) | Derivados de ciclohexano espirociclicos | |
| AR011101A1 (es) | Compuesto derivado de acidos arilsulfonilaminohidroxiamicos y composicion farmaceutica que lo contiene | |
| UY27436A1 (es) | Compuestos químicos | |
| BR0212277A (pt) | Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica | |
| DK1313695T3 (da) | Estere af 5-aminolevulinsyre som fotosensibiliserende midler i fotokemoterapi | |
| UY29886A1 (es) | Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones | |
| UY29919A1 (es) | Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones | |
| AR040773A1 (es) | Pirazoles utiles como inhibidores de gsk-3 | |
| CY1113873T1 (el) | Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90 | |
| DOP2005000046A (es) | Compuestos de acido alfa arilo o heteroaril metil beta piperidino propanoico como antagonistas del receptor orl1 | |
| WO2006008250A3 (en) | Oxime derivatives and the use therof as latent acids | |
| EA200870321A1 (ru) | Способ получения 4-оксохинолинового соединения | |
| HRP20050390A2 (en) | Substituted benzoxazinones and uses thereof | |
| AR035777A1 (es) | Derivados de pirazol sustituidos, procesos para su preparacion, composiciones farmaceuticas que los contienen, y su uso en medicina | |
| DOP2002000399A (es) | Nuevos derivados de acido sulfonico | |
| UY27685A1 (es) | Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso | |
| NO20050612L (no) | Pyrrolidinderivater som oksytocinantagonister | |
| FI954016A0 (fi) | Uudet yhdisteet | |
| AR029461A1 (es) | Derivados de 4-fenil-1-piperazinilo, - piperidinilo y -tetrahidropiridilo , composiciones farmaceuticas que los comprenden y el uso de los mismos para la fabricacion de un medicamento | |
| DE60228724D1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
| EA200970497A1 (ru) | Производные пиррола, их получение и их применение в терапии | |
| AR052669A1 (es) | Esteres de acido de acido propano - fosfinico sustituido; composiciones farmaceuticas que los contienen y su uso para el tratamiento de trastornos psiquiatricos. | |
| AR044320A1 (es) | Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a | |
| BRPI0406893A (pt) | Derivados de acilaminotiazol, a respectiva preparação e a respectiva utilização como inibidores da produção do peptìdeo betaamilóide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |