AR049019A1 - Sintesis regioespecifica de derivados de 42-ester de rapamicina, composicion y kit farmaceutico - Google Patents
Sintesis regioespecifica de derivados de 42-ester de rapamicina, composicion y kit farmaceuticoInfo
- Publication number
- AR049019A1 AR049019A1 ARP050101447A ARP050101447A AR049019A1 AR 049019 A1 AR049019 A1 AR 049019A1 AR P050101447 A ARP050101447 A AR P050101447A AR P050101447 A ARP050101447 A AR P050101447A AR 049019 A1 AR049019 A1 AR 049019A1
- Authority
- AR
- Argentina
- Prior art keywords
- rapamycin
- ester derivatives
- lipase
- composition
- pharmaceutical kit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Reivindicacion 1: Un método para la preparacion regioespecífica de derivados 42-éster de rapamicina de la formula (1) en la cual R es un hidrocarburo lineal o cíclico, alifático o aromático, saturado o insaturado el cual contiene opcionalmente hidroxilo, halogeno y/o tio, comprendiendo dicho método acilar un 42-hidroxi rapamicina con un donador de acilo en presencia de una lipasa. Reivindicacion 2: El método de acuerdo con la reivindicacion 1, en el cual la lipasa utilizada es una lipasa microbiana de microorganismos tales como Aspergillus niger, Candida antarctica, Candida rugosa, Mucor miehei, Pseudomonas cepacia, Pseudomonas fluorescens, Rhizopus delemar. Reivindicacion 4: El método de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde el donador de acilo es un viniléster, un isopropeniléster o un anhídrido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56192604P | 2004-04-14 | 2004-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049019A1 true AR049019A1 (es) | 2006-06-21 |
Family
ID=34965235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101447A AR049019A1 (es) | 2004-04-14 | 2005-04-13 | Sintesis regioespecifica de derivados de 42-ester de rapamicina, composicion y kit farmaceutico |
Country Status (23)
Country | Link |
---|---|
US (1) | US7268144B2 (es) |
EP (1) | EP1737869A1 (es) |
JP (1) | JP4224115B2 (es) |
KR (1) | KR20070015544A (es) |
CN (1) | CN1942476A (es) |
AR (1) | AR049019A1 (es) |
AU (1) | AU2005238431A1 (es) |
BR (1) | BRPI0509852A (es) |
CA (1) | CA2562952A1 (es) |
CL (1) | CL2008000507A1 (es) |
CR (1) | CR8646A (es) |
EC (1) | ECSP066927A (es) |
GT (1) | GT200500085A (es) |
IL (1) | IL178315A0 (es) |
MX (1) | MXPA06011881A (es) |
NO (1) | NO20065090L (es) |
PA (1) | PA8629901A1 (es) |
PE (1) | PE20060253A1 (es) |
RU (1) | RU2387657C2 (es) |
SG (1) | SG152234A1 (es) |
TW (1) | TW200536542A (es) |
UA (1) | UA87492C2 (es) |
WO (1) | WO2005105811A1 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100402031C (zh) | 2002-07-30 | 2008-07-16 | 惠氏公司 | 含有瑞帕霉素羟基酯的胃肠外制剂 |
AU2005238432A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
JP2007534337A (ja) * | 2004-04-27 | 2007-11-29 | ワイス | ラパマイシン特異的メチラーゼを用いるラパマイシンの標識 |
WO2006038972A1 (en) * | 2004-08-10 | 2006-04-13 | Wyeth | Cci-779 derivatives and methods of making same |
MX2007009590A (es) | 2005-02-09 | 2007-09-12 | Wyeth Corp | Polimorfo cci-779 y uso del mismo. |
US7538119B2 (en) * | 2005-11-04 | 2009-05-26 | Wyeth | 41-Methoxy isotope labeled rapamycin 42-ester |
EP1957500A1 (en) * | 2005-12-07 | 2008-08-20 | Wyeth a Corporation of the State of Delaware | Process for the preparation of purified crystalline cci-779 |
AR058283A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido |
US7622578B2 (en) * | 2005-12-07 | 2009-11-24 | Wyeth | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
BRPI0708562A2 (pt) * | 2006-03-07 | 2011-06-07 | Wyeth Corp | processos para preparar conjugados de polietileno glicor de macrolìdeos imunossupressores, um macrolìdeo imunossupressor peguilado, uma rapamicina peguilada, um everolimus peguilado, um cci-779 peguilado e um tacrolimus peguilado, e, produto |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
US20090253733A1 (en) * | 2008-04-02 | 2009-10-08 | Biointeractions, Ltd. | Rapamycin carbonate esters |
WO2009131631A1 (en) * | 2008-04-14 | 2009-10-29 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
CN101676291B (zh) * | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
US20120064143A1 (en) | 2008-11-11 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
IT1394309B1 (it) | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
CA2828829A1 (en) * | 2011-04-01 | 2012-10-04 | Sandoz Ag | Regioselective acylation of rapamycin at the c-42 position |
US10751450B2 (en) | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
SG11201405777YA (en) * | 2012-06-08 | 2014-10-30 | Biotronik Ag | Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods |
WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
ES2897473T3 (es) * | 2013-03-15 | 2022-03-01 | Biosensors Int Group Ltd | Purificación de derivados de la rapamicina |
AU2014373683B2 (en) | 2013-12-31 | 2020-05-07 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
ES2871499T3 (es) | 2017-05-15 | 2021-10-29 | Bard Inc C R | Dispositivo médico con recubrimiento de elución de fármaco y capa intermedia |
AU2018370237A1 (en) * | 2017-11-20 | 2020-06-04 | Icahn School Of Medicine At Mount Sinai | Inhibiting trained immunity with a therapeutic nanobilogic composition |
EP3880266A1 (en) | 2018-11-14 | 2021-09-22 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
US20220176084A1 (en) | 2019-04-08 | 2022-06-09 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
US20240100025A1 (en) * | 2020-12-14 | 2024-03-28 | Biotronik Ag | Materials and Methods for Treating Viral and Other Medical Conditions |
EP4308105A1 (en) | 2021-03-19 | 2024-01-24 | Trained Therapeutix Discovery, Inc. | Compounds for regulating trained immunity, and their methods of use |
WO2023070605A1 (en) * | 2021-10-29 | 2023-05-04 | Trevena, Inc. | Methods of preparing 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds |
CN118027062A (zh) * | 2023-11-03 | 2024-05-14 | 沈阳药科大学 | 一种雷帕霉素前药及其纳米制剂的制备和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5210030A (en) * | 1990-06-25 | 1993-05-11 | Merck & Co., Inc. | Process for selectively acylating immunomycin |
PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5233036A (en) | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
TWI256395B (en) * | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
DK1319008T3 (da) | 2000-09-19 | 2009-02-09 | Wyeth Corp | Vandoplöselige rapamycinestere |
CN100402031C (zh) | 2002-07-30 | 2008-07-16 | 惠氏公司 | 含有瑞帕霉素羟基酯的胃肠外制剂 |
WO2005016935A2 (en) | 2003-08-07 | 2005-02-24 | Wyeth | Regioselective synthesis of cci-779 |
BRPI0414066A (pt) | 2003-09-03 | 2006-10-24 | Wyeth Corp | 42-éster de rapamicina amorfo com ácido 3-hidróxi-2-( hidroximetil )-2-metilproipiÈnico e composições farmacêuticas que o contenha |
EP1701698B1 (en) * | 2004-01-08 | 2008-01-16 | Wyeth a Corporation of the State of Delaware | Directly compressible pharmaceutical composition for the oral admimistration of cci-779 |
-
2005
- 2005-04-12 WO PCT/US2005/012266 patent/WO2005105811A1/en active Application Filing
- 2005-04-12 JP JP2007508442A patent/JP4224115B2/ja not_active Expired - Fee Related
- 2005-04-12 US US11/103,799 patent/US7268144B2/en not_active Expired - Fee Related
- 2005-04-12 KR KR1020067021378A patent/KR20070015544A/ko not_active Application Discontinuation
- 2005-04-12 MX MXPA06011881A patent/MXPA06011881A/es active IP Right Grant
- 2005-04-12 RU RU2006134014/04A patent/RU2387657C2/ru not_active IP Right Cessation
- 2005-04-12 AU AU2005238431A patent/AU2005238431A1/en not_active Abandoned
- 2005-04-12 BR BRPI0509852-1A patent/BRPI0509852A/pt not_active IP Right Cessation
- 2005-04-12 CN CNA2005800112769A patent/CN1942476A/zh active Pending
- 2005-04-12 SG SG200902515-6A patent/SG152234A1/en unknown
- 2005-04-12 EP EP05733853A patent/EP1737869A1/en not_active Withdrawn
- 2005-04-12 CA CA002562952A patent/CA2562952A1/en not_active Abandoned
- 2005-04-13 GT GT200500085A patent/GT200500085A/es unknown
- 2005-04-13 PA PA20058629901A patent/PA8629901A1/es unknown
- 2005-04-13 TW TW094111640A patent/TW200536542A/zh unknown
- 2005-04-13 PE PE2005000409A patent/PE20060253A1/es not_active Application Discontinuation
- 2005-04-13 AR ARP050101447A patent/AR049019A1/es unknown
- 2005-12-04 UA UAA200610949A patent/UA87492C2/ru unknown
-
2006
- 2006-09-21 CR CR8646A patent/CR8646A/es not_active Application Discontinuation
- 2006-09-26 IL IL178315A patent/IL178315A0/en unknown
- 2006-10-16 EC EC2006006927A patent/ECSP066927A/es unknown
- 2006-11-03 NO NO20065090A patent/NO20065090L/no not_active Application Discontinuation
-
2008
- 2008-02-19 CL CL200800507A patent/CL2008000507A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US7268144B2 (en) | 2007-09-11 |
JP4224115B2 (ja) | 2009-02-12 |
JP2007532134A (ja) | 2007-11-15 |
ECSP066927A (es) | 2006-12-20 |
PE20060253A1 (es) | 2006-03-30 |
CA2562952A1 (en) | 2005-11-10 |
CR8646A (es) | 2007-08-28 |
BRPI0509852A (pt) | 2007-10-23 |
UA87492C2 (en) | 2009-07-27 |
WO2005105811A1 (en) | 2005-11-10 |
SG152234A1 (en) | 2009-05-29 |
NO20065090L (no) | 2006-11-13 |
RU2387657C2 (ru) | 2010-04-27 |
MXPA06011881A (es) | 2006-12-14 |
CN1942476A (zh) | 2007-04-04 |
GT200500085A (es) | 2005-11-03 |
KR20070015544A (ko) | 2007-02-05 |
CL2008000507A1 (es) | 2008-07-04 |
TW200536542A (en) | 2005-11-16 |
IL178315A0 (en) | 2007-02-11 |
RU2006134014A (ru) | 2008-05-20 |
EP1737869A1 (en) | 2007-01-03 |
AU2005238431A1 (en) | 2005-11-10 |
PA8629901A1 (es) | 2006-06-02 |
US20050234234A1 (en) | 2005-10-20 |
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