AR045212A1 - Derivados de acido butenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y uso para el tratamiento de dislipidemia, aterosclerosis y diabetes - Google Patents
Derivados de acido butenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y uso para el tratamiento de dislipidemia, aterosclerosis y diabetesInfo
- Publication number
- AR045212A1 AR045212A1 ARP040102771A ARP040102771A AR045212A1 AR 045212 A1 AR045212 A1 AR 045212A1 AR P040102771 A ARP040102771 A AR P040102771A AR P040102771 A ARP040102771 A AR P040102771A AR 045212 A1 AR045212 A1 AR 045212A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- dyslipidemia
- diabetes
- procedures
- pharmaceutical compositions
- Prior art date
Links
- 208000032928 Dyslipidaemia Diseases 0.000 title abstract 2
- 208000017170 Lipid metabolism disease Diseases 0.000 title abstract 2
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical class C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a derivados de ácido butenoico de la fórmula (1) en donde R1 representa un grupo arilo C6-18, que está opcionalmente sustituido y/u opcionalmente condensado a un núcleo saturado o insaturado, monocíclico o policíclico de 5 a 8 miembros que opcionalmente contiene uno o varios heteroátomos seleccionados de O, N y S, estando dicho núcleo en sí mismo opcionalmente sustituido; un grupo heterocíclico monocíclico opcionalmente sustituido, saturado, insaturado o aromático de 5 a 8 miembros que contiene uno o varios heteroátomos seleccionados de O, N y S; un grupo alquenilo C2-10 opcionalmente sustituido; un grupo alquilo C1-10; R2 y R3 representan, de modo independiente, un átomo de H, un arilo C6-18 opcionalmente sustituido, o , de modo alternativo, R2 y R3 representan juntos una cadena de alquileno C3-6; y R representa un átomo de H, un grupo alquilo C1-10; un grupo aril C(6-18)-alquilo(C1-10); y sus sales con ácidos o bases, entendiéndose que los siguientes compuestos quedan excluídos de la protección: cuando R3 = fenilo; R = etilo; R1 = etilo o fenilo; y R2 = H, y también sus derivados, derivados de solvatos y estereoisómeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Y también a procedimientos para su preparación, a composiciones farmacéuticas que los comprenden y a su uso para el tratamiento de dislipidemia, aterosclerosis y diabetes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0309610A FR2858615B1 (fr) | 2003-08-04 | 2003-08-04 | Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045212A1 true AR045212A1 (es) | 2005-10-19 |
Family
ID=34073009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102771A AR045212A1 (es) | 2003-08-04 | 2004-08-04 | Derivados de acido butenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y uso para el tratamiento de dislipidemia, aterosclerosis y diabetes |
Country Status (8)
Country | Link |
---|---|
US (2) | US7820847B2 (es) |
EP (1) | EP1658260A1 (es) |
JP (1) | JP4908211B2 (es) |
AR (1) | AR045212A1 (es) |
AU (1) | AU2004263254B2 (es) |
CA (1) | CA2534493C (es) |
FR (1) | FR2858615B1 (es) |
WO (1) | WO2005014521A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023110750A1 (en) | 2021-12-13 | 2023-06-22 | Global Bioenergies | Acyl-coa hydrolase variants |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS582202B2 (ja) * | 1975-12-10 | 1983-01-14 | ダイニツポンジヨチユウギク カブシキガイシヤ | サツチユウザイ オヨビ ソノセイホウ |
JP2001261612A (ja) * | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
FR2869610B1 (fr) * | 2004-05-03 | 2006-07-28 | Merck Sante Soc Par Actions Si | Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques |
-
2003
- 2003-08-04 FR FR0309610A patent/FR2858615B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-14 JP JP2006522255A patent/JP4908211B2/ja not_active Expired - Fee Related
- 2004-07-14 EP EP04740992A patent/EP1658260A1/en not_active Withdrawn
- 2004-07-14 CA CA2534493A patent/CA2534493C/en not_active Expired - Fee Related
- 2004-07-14 AU AU2004263254A patent/AU2004263254B2/en not_active Ceased
- 2004-07-14 WO PCT/EP2004/007776 patent/WO2005014521A1/en active Application Filing
- 2004-07-14 US US10/566,995 patent/US7820847B2/en not_active Expired - Fee Related
- 2004-08-04 AR ARP040102771A patent/AR045212A1/es unknown
-
2010
- 2010-06-23 US US12/821,384 patent/US8247448B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2534493A1 (en) | 2005-02-17 |
US20060178434A1 (en) | 2006-08-10 |
US7820847B2 (en) | 2010-10-26 |
FR2858615A1 (fr) | 2005-02-11 |
AU2004263254B2 (en) | 2010-03-18 |
JP4908211B2 (ja) | 2012-04-04 |
WO2005014521A1 (en) | 2005-02-17 |
US8247448B2 (en) | 2012-08-21 |
US20100261789A1 (en) | 2010-10-14 |
FR2858615B1 (fr) | 2006-12-22 |
AU2004263254A1 (en) | 2005-02-17 |
JP2007501190A (ja) | 2007-01-25 |
EP1658260A1 (en) | 2006-05-24 |
CA2534493C (en) | 2012-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR048717A1 (es) | Derivados de acido hexenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y sus aplicaciones terapeuticas | |
AR016762A1 (es) | Compuestos del acido 4-bromo o 4-yodo fenilamino benzohidroxamico, formulaciones farmaceuticas y uso del mismo | |
AR033306A1 (es) | Compuestos | |
AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
AR021354A1 (es) | Procedimiento para la preparacion de un compuesto derivado de quinolina y un procedimiento para preparar una composicion farmaceutica | |
RS52853B (en) | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | |
AR048934A1 (es) | Morfolinas | |
RU2007138937A (ru) | Производные 1-бензилиндол-2-карбоксамида | |
CY1105035T1 (el) | Συγχωνευμενα με αρυλιο ή ετεροαρυλιο παραγωγα της ιμιδαζολης ως αντιφλεγμονωδεις και αναλγητικοι παραγοντες | |
AR063022A1 (es) | Derivados de indol antagonistas del receptor de glucagon, composiciones farmaceuticas que los contienen y usos para tratar diabetes mellitus tipo 2 y estados patologicos relacionados. | |
CL2004000382A1 (es) | Tetrahidroisoquinolinas sustituidas, proceso de preparacion, y composicion farmaceutica, utiles en el tratamiento y prevencion de estados patologicos que se alivian con un agonista de 5-ht6. | |
AR024060A1 (es) | Nuevos compuestos farmaceuticamente activos | |
UY26727A1 (es) | Derivados de tropano útiles en terapia | |
AR044829A1 (es) | Derivados de bis-4-cloro fenil pirazinas | |
AR056574A1 (es) | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso | |
EA200500822A1 (ru) | Замещённый индолпиридиний в качестве противоинфекционных соединений | |
AR041395A1 (es) | Compuesto de piridina composicion farmaceutica que lo comprende y su uso para prepararla | |
AR067975A1 (es) | Derivados de la n-bencil, n-arilcarbonilpiperazina | |
AR050154A1 (es) | Derivados de acido butanoico, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden | |
RU2017117559A (ru) | Бензопроизводные с шестичленным кольцом в качестве ингибитора dpp-4 и их применение | |
AR067454A1 (es) | Derivados de indano- amina, su preparacion y uso como medicamentos | |
AR012732A1 (es) | Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentos | |
AR041340A1 (es) | Derivados de tiazolpirimidinona,proceso de preparacion y composiciones farmaceuticas que los contienen | |
PE20011183A1 (es) | Metabolitos agonistas/antagonistas de estrogeno | |
CO5601010A2 (es) | Derivados de oxazolidinona, procesos para su preparacion y composiciones farmaceuticas que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |