AR044720A1 - Una sulfonamida heterociclica, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, y compuestos utiles como intermediari0s - Google Patents

Una sulfonamida heterociclica, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, y compuestos utiles como intermediari0s

Info

Publication number
AR044720A1
AR044720A1 ARP000100921A ARP000100921A AR044720A1 AR 044720 A1 AR044720 A1 AR 044720A1 AR P000100921 A ARP000100921 A AR P000100921A AR P000100921 A ARP000100921 A AR P000100921A AR 044720 A1 AR044720 A1 AR 044720A1
Authority
AR
Argentina
Prior art keywords
heterociclical
intermediaries
sulfonamide
understands
prepare
Prior art date
Application number
ARP000100921A
Other languages
English (en)
Inventor
Volker Breu
Philippe Coassolo
Werner Neidhart
Sebastien Roux
Peter Weiss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR044720A1 publication Critical patent/AR044720A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Las sulfonamidas heterocíclicas de fórmula (1), en la cual R1 es un residuo heterocíclico seleccionado entre piridilo y tiazolilo, donde el mencionado residuo heterocíclico puede sustituir opcionalmente con alquilo inferior o alquenilo inferior; y las sales farmacéuticamente aceptables de la misma, que son inhibidores de los receptores de la endotelina y por ende, pueden emplearse en el tratamiento de los trastornos que se asocian con el tono vascular anormal y la disfunción endotelial. Además, se describe su uso para preparar medicamentos; un proceso para su preparación, composiciones farmacéuticas que las comprenden; y compuestos útiles como intermediarios.
ARP000100921A 1999-03-03 2000-03-02 Una sulfonamida heterociclica, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, y compuestos utiles como intermediari0s AR044720A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99104306 1999-03-03

Publications (1)

Publication Number Publication Date
AR044720A1 true AR044720A1 (es) 2005-10-05

Family

ID=8237697

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100921A AR044720A1 (es) 1999-03-03 2000-03-02 Una sulfonamida heterociclica, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, y compuestos utiles como intermediari0s

Country Status (30)

Country Link
US (2) US6417360B1 (es)
EP (1) EP1185525B1 (es)
JP (1) JP3488203B2 (es)
KR (1) KR100478798B1 (es)
CN (1) CN1342158B (es)
AR (1) AR044720A1 (es)
AT (1) ATE353325T1 (es)
AU (1) AU756738B2 (es)
BR (1) BR0008717A (es)
CA (1) CA2364906C (es)
CY (1) CY1108002T1 (es)
CZ (1) CZ300324B6 (es)
DE (1) DE60033280T2 (es)
DK (1) DK1185525T3 (es)
ES (1) ES2280198T3 (es)
HK (1) HK1044943B (es)
HR (1) HRP20010630B1 (es)
HU (1) HUP0200080A3 (es)
ID (1) ID30484A (es)
IL (1) IL145051A0 (es)
MA (1) MA26776A1 (es)
NO (1) NO320809B1 (es)
NZ (1) NZ513671A (es)
PL (1) PL198815B1 (es)
PT (1) PT1185525E (es)
RS (1) RS50109B (es)
RU (1) RU2201928C1 (es)
TR (1) TR200102562T2 (es)
WO (1) WO2000052007A1 (es)
ZA (1) ZA200107157B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
US20020184047A1 (en) * 2001-04-03 2002-12-05 Plotnick Michael A. Universal ad queue
EP1454625A1 (en) * 2003-03-06 2004-09-08 Speedel Development AG Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies
EP1595880A1 (en) * 2004-05-13 2005-11-16 Speedel Pharma AG Crystalline forms of a pyridinyl-sulfonamide and their use as endothelin receptor antagonists
CN101257947A (zh) * 2005-09-12 2008-09-03 斯皮德尔药品公司 用于预防血管移植失败的吡啶磺酰胺基-嘧啶类
BRPI0709950A2 (pt) * 2006-04-13 2011-08-02 Actelion Pharmaceuticals Ltd uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin
EP1938812A1 (en) * 2006-12-22 2008-07-02 Speedel Pharma AG Pharmaceutical composition using aliskiren and avosentan
WO2010011868A2 (en) * 2008-07-23 2010-01-28 Auspex Pharmaceuticals Pyridine sulfonamide modulators of endothelin-a-receptor
WO2016123291A1 (en) 2015-01-29 2016-08-04 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
KR101936054B1 (ko) 2017-06-23 2019-01-11 한국과학기술연구원 항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학 조성물
TW202329952A (zh) 2021-12-17 2023-08-01 瑞士商愛杜西亞製藥有限公司 克拉生坦(clazosentan)二鈉鹽之製備方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1064965C (zh) * 1994-11-25 2001-04-25 弗·哈夫曼-拉罗切有限公司 新的磺酰胺类化合物及其作为药物的用途
US5837708A (en) 1994-11-25 1998-11-17 Hoffmann-La Roche Inc. Sulphonamides
CA2162630C (en) 1994-11-25 2007-05-01 Volker Breu Sulfonamides
TW313568B (es) 1994-12-20 1997-08-21 Hoffmann La Roche
ES2221696T3 (es) 1997-08-19 2005-01-01 F. Hoffmann-La Roche Ag Procedimiento para la preparacion de piridinas 2,5.disustituidas.
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides

Also Published As

Publication number Publication date
TR200102562T2 (tr) 2002-02-21
IL145051A0 (en) 2002-06-30
EP1185525A1 (en) 2002-03-13
NO20014224L (no) 2001-08-31
HUP0200080A2 (en) 2002-06-29
BR0008717A (pt) 2001-12-26
HUP0200080A3 (en) 2003-01-28
AU3161100A (en) 2000-09-21
CZ20013108A3 (cs) 2002-02-13
US6521631B2 (en) 2003-02-18
PT1185525E (pt) 2007-05-31
HRP20010630A2 (en) 2002-08-31
CN1342158A (zh) 2002-03-27
NO20014224D0 (no) 2001-08-31
EP1185525B1 (en) 2007-02-07
HK1044943A1 (es) 2002-11-08
CY1108002T1 (el) 2013-09-04
DK1185525T3 (da) 2007-06-04
DE60033280D1 (de) 2007-03-22
WO2000052007A1 (en) 2000-09-08
ZA200107157B (en) 2002-11-29
US20020137933A1 (en) 2002-09-26
RU2201928C1 (ru) 2003-04-10
CZ300324B6 (cs) 2009-04-22
JP2002538156A (ja) 2002-11-12
JP3488203B2 (ja) 2004-01-19
HK1044943B (zh) 2013-03-22
RU2001126348A (ru) 2004-03-20
CA2364906A1 (en) 2000-09-08
NO320809B1 (no) 2006-01-30
AU756738B2 (en) 2003-01-23
DE60033280T2 (de) 2007-11-22
ATE353325T1 (de) 2007-02-15
MA26776A1 (fr) 2004-12-20
PL351794A1 (en) 2003-06-16
CN1342158B (zh) 2012-06-06
CA2364906C (en) 2006-01-10
KR20010102480A (ko) 2001-11-15
YU62801A (sh) 2004-07-15
NZ513671A (en) 2003-04-29
ID30484A (id) 2001-12-13
ES2280198T3 (es) 2007-09-16
PL198815B1 (pl) 2008-07-31
US6417360B1 (en) 2002-07-09
HRP20010630B1 (en) 2010-08-31
KR100478798B1 (ko) 2005-03-24
RS50109B (sr) 2009-03-25

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