AR043477A1 - Compuestos biciclicos aromaticos sustituidos con amino-alquilo y composiciones farmaceuticas que los contienen - Google Patents
Compuestos biciclicos aromaticos sustituidos con amino-alquilo y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR043477A1 AR043477A1 ARP020103080A ARP020103080A AR043477A1 AR 043477 A1 AR043477 A1 AR 043477A1 AR P020103080 A ARP020103080 A AR P020103080A AR P020103080 A ARP020103080 A AR P020103080A AR 043477 A1 AR043477 A1 AR 043477A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- independently
- mean
- alkylene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 21
- 229910052757 nitrogen Inorganic materials 0.000 abstract 9
- 229910052799 carbon Inorganic materials 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos bicíclicos aromáticos sustituidos con amino alquilo de la fórmula (1) en los que A significa alquilo C1-8, alquilen C0-8, un anillo monocíclico o bicíclico de 3-12 miembros que puede contener uno o varios heteroátomos seleccionados entre el grupo formado por N, O y S, y el anillo de 3-12 miembros puede llevar otros sustituyentes adicionales tales como F, Cl, Br, NO2, CF3, OCF3, CN, alquilo C1-6, arilo, CON(R37)(R38), N(R39)(R40), OH, O-alquilo C1-6, S-alquilo C1-6 o NCO-alquilo C1-6; X significa un enlace, C(R8)(R9), C(OR10)(R11), O, N(R12), S, SO, SO2, CO; R8, R9, R10, R11, R12 independientemente unos de otros, significan H, alquilo C1-6; D significa N, C(R41); E significa N, C(R42); G significa N, C(R43); L significa N, C(R44); R1, R2, R3, R41, R42, R43, R44 independientemente unos de otros, significan H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, alcoxi-alquilo C1-4, S-alquilo C1-6, alquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, O-cicloalquilo C3-8, cicloalquenilo C3-8, O-cicloalquenilo C3-8, alquinilo C2-6, alquilen C0-8-arilo, O-alquilen C0-8-arilo, S-arilo, N(R13)(R14), SO2-CH3, COOH, COO-alquilo C1-6, CON(R15)(R16), N(R17)CO(R18), N(R19)SO2(R20), CO(R21), un heterociclo de 5-7 miembros con 1-4 heteroátomos; R13, R14 independientemente uno de otro, significan H, alquilo C1-6, o R13 y R14 forman en común con el átomo de N, al que están unidos, un anillo de 5-6 miembros, pudiendo en el caso del anillo de 6 miembros un grupo CH2 estar reemplazado por O o S; R15, R16 independientemente uno de otro, significan H, alquilo C1-6, o R15 y R16 forman en común con el átomo de N, al que están unidos, un anillo de 5-6 miembros, pudiendo en el caso del anillo de 6 miembros un grupo CH2 estar reemplazado por O o S; R17, R19 independientemente uno de otro, significan, H, alquilo C1-6; R18, R20, R21 independientemente unos de otros, significan alquilo C1-6, arilo; B significa N(R24), O; R24 significa H, alquilo C1-6; R5 significa H, alquilo C1-6; W significa N, C(R25); R25 significa H, alquilo C1-6, arilo, un enlace Y; T significa N, C(R26); R26 significa H, alquilo C1-6, arilo, alquilen C0-8-arilo, un enlace con Y; U significa O, S, N(R27), -C(R30)=N-, -N=C(R31)-; R27, R30, R31 independientemente unos de otros, significan H, alquilo C1-6, un enlace con Y; Y significa alquileno C1-8, en el que uno o varios átomos de C pueden estar reemplazados por O, S, SO, SO2, C(R32)(R33), CO, C(R34)(OR35) o N (R36); R32, R33, R34, R35, R36 independientemente unos de otros, significan H, alquilo C1-6, arilo; R6, R7 independientemente uno de otro, significan H, alquilo c1-6, cicloalquilo C3-7; o R6 e Y o R6 y R7 forman en común con el átomo de N, al que están unidos, un anillo de 3-8 miembros, en el que uno o varios átomos de C pueden estar reemplazados por O, N, o S y el anillo de 3-8 miembros puede llevar otros sustituyentes adicionales tales como alquilo C1-6, arilo, CON(R37)(R38), N(R39)(R40), OH, O-alquilo C1-6 o NCO-alquilo C1-6; R37, R38, R39, R40 independientemente unos de otros, significan H, alquilo C1-6; así como sus sales fisiológicamente compatibles; medicamentos y procedimientos para su preparación. Utilización de dichos compuestos para la preparación de medicamentos para destinarlos a la profilaxis o al tratamiento de la obesidad y la diabetes del tipo II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10139416A DE10139416A1 (de) | 2001-08-17 | 2001-08-17 | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043477A1 true AR043477A1 (es) | 2005-08-03 |
Family
ID=7695086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103080A AR043477A1 (es) | 2001-08-17 | 2002-08-15 | Compuestos biciclicos aromaticos sustituidos con amino-alquilo y composiciones farmaceuticas que los contienen |
Country Status (23)
Country | Link |
---|---|
US (5) | US20030212070A1 (es) |
EP (1) | EP1418906A1 (es) |
JP (1) | JP2005505530A (es) |
KR (1) | KR20040043197A (es) |
CN (1) | CN1555260A (es) |
AR (1) | AR043477A1 (es) |
BR (1) | BR0211989A (es) |
CA (1) | CA2457037A1 (es) |
DE (1) | DE10139416A1 (es) |
EE (1) | EE200400055A (es) |
GT (1) | GT200200165A (es) |
HR (1) | HRP20040149A2 (es) |
HU (1) | HUP0401329A2 (es) |
IL (1) | IL160424A0 (es) |
MX (1) | MXPA04001307A (es) |
NO (1) | NO20040678L (es) |
PA (1) | PA8553001A1 (es) |
PE (1) | PE20030333A1 (es) |
PL (1) | PL366794A1 (es) |
RU (1) | RU2004107654A (es) |
UY (1) | UY27417A1 (es) |
WO (1) | WO2003015769A1 (es) |
ZA (1) | ZA200401221B (es) |
Families Citing this family (87)
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CN1585751A (zh) | 2001-10-25 | 2005-02-23 | 武田药品工业株式会社 | 喹啉化合物 |
AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
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AU2003296895A1 (en) * | 2002-08-20 | 2004-05-04 | The Regents Of The University Of California | Combination therapy for controlling appetites |
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JPWO2004069798A1 (ja) * | 2003-02-10 | 2006-05-25 | 萬有製薬株式会社 | ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤 |
DE10314610A1 (de) | 2003-04-01 | 2004-11-04 | Aventis Pharma Deutschland Gmbh | Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung |
AU2004266233A1 (en) | 2003-08-13 | 2005-03-03 | Amgen, Inc. | Melanin concentrating hormone receptor antagonist |
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DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
US5599930A (en) * | 1991-07-03 | 1997-02-04 | The Upjohn Company | Substituted indoles as anti-AIDS pharmaceuticals |
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ATE236137T1 (de) * | 1996-02-02 | 2003-04-15 | Merck & Co Inc | Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit |
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WO1998047868A1 (en) * | 1997-04-18 | 1998-10-29 | Smithkline Beecham Plc | Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists |
EP1047691A1 (en) * | 1997-12-12 | 2000-11-02 | Smithkline Beecham Plc | Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists |
EP1218336A2 (en) * | 1999-09-20 | 2002-07-03 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
YU91002A (sh) * | 2000-06-09 | 2006-05-25 | Aventis Pharma Deutschland | Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka |
FR2810979B1 (fr) * | 2000-06-29 | 2002-08-23 | Adir | Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-08-17 DE DE10139416A patent/DE10139416A1/de not_active Withdrawn
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2002
- 2002-08-03 CN CNA02818162XA patent/CN1555260A/zh active Pending
- 2002-08-03 IL IL16042402A patent/IL160424A0/xx unknown
- 2002-08-03 JP JP2003520728A patent/JP2005505530A/ja not_active Withdrawn
- 2002-08-03 RU RU2004107654/04A patent/RU2004107654A/ru not_active Application Discontinuation
- 2002-08-03 CA CA002457037A patent/CA2457037A1/en not_active Abandoned
- 2002-08-03 KR KR10-2004-7002348A patent/KR20040043197A/ko not_active Application Discontinuation
- 2002-08-03 WO PCT/EP2002/008686 patent/WO2003015769A1/de not_active Application Discontinuation
- 2002-08-03 MX MXPA04001307A patent/MXPA04001307A/es unknown
- 2002-08-03 HU HU0401329A patent/HUP0401329A2/hu unknown
- 2002-08-03 EP EP02774498A patent/EP1418906A1/de not_active Withdrawn
- 2002-08-03 PL PL02366794A patent/PL366794A1/xx unknown
- 2002-08-03 BR BR0211989-7A patent/BR0211989A/pt not_active Application Discontinuation
- 2002-08-14 US US10/218,034 patent/US20030212070A1/en not_active Abandoned
- 2002-08-15 AR ARP020103080A patent/AR043477A1/es not_active Application Discontinuation
- 2002-08-15 UY UY27417A patent/UY27417A1/es unknown
- 2002-08-16 PA PA20028553001A patent/PA8553001A1/es unknown
- 2002-08-16 GT GT200200165A patent/GT200200165A/es unknown
- 2002-08-16 PE PE2002000743A patent/PE20030333A1/es not_active Application Discontinuation
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2003
- 2003-08-03 EE EEP200400055A patent/EE200400055A/xx unknown
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2004
- 2004-02-16 ZA ZA200401221A patent/ZA200401221B/en unknown
- 2004-02-16 NO NO20040678A patent/NO20040678L/no not_active Application Discontinuation
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- 2004-04-09 US US10/820,706 patent/US20040192693A1/en not_active Abandoned
- 2004-04-09 US US10/820,703 patent/US20040198731A1/en not_active Abandoned
- 2004-04-09 US US10/820,736 patent/US20040198732A1/en not_active Abandoned
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US20040198731A1 (en) | 2004-10-07 |
PL366794A1 (en) | 2005-02-07 |
IL160424A0 (en) | 2004-07-25 |
BR0211989A (pt) | 2004-09-28 |
US20040198733A1 (en) | 2004-10-07 |
US20040192693A1 (en) | 2004-09-30 |
UY27417A1 (es) | 2002-11-29 |
JP2005505530A (ja) | 2005-02-24 |
CA2457037A1 (en) | 2003-02-27 |
MXPA04001307A (es) | 2004-05-20 |
EP1418906A1 (de) | 2004-05-19 |
RU2004107654A (ru) | 2005-09-10 |
US20040198732A1 (en) | 2004-10-07 |
PA8553001A1 (es) | 2003-02-28 |
GT200200165A (es) | 2003-05-22 |
KR20040043197A (ko) | 2004-05-22 |
NO20040678L (no) | 2004-05-13 |
ZA200401221B (en) | 2004-10-27 |
PE20030333A1 (es) | 2003-04-24 |
HRP20040149A2 (en) | 2004-08-31 |
CN1555260A (zh) | 2004-12-15 |
EE200400055A (et) | 2004-04-15 |
HUP0401329A2 (hu) | 2004-12-28 |
DE10139416A1 (de) | 2003-03-06 |
US20030212070A1 (en) | 2003-11-13 |
WO2003015769A1 (de) | 2003-02-27 |
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