AR042625A1 - Compuestos moduladores de los receptores de tipo ppar gamma - Google Patents

Compuestos moduladores de los receptores de tipo ppar gamma

Info

Publication number
AR042625A1
AR042625A1 ARP030104594A ARP030104594A AR042625A1 AR 042625 A1 AR042625 A1 AR 042625A1 AR P030104594 A ARP030104594 A AR P030104594A AR P030104594 A ARP030104594 A AR P030104594A AR 042625 A1 AR042625 A1 AR 042625A1
Authority
AR
Argentina
Prior art keywords
radical
alkyl
aralkyl
hydrogen atom
heterocyclic
Prior art date
Application number
ARP030104594A
Other languages
English (en)
Inventor
Laurence Clary
Pascal Collette
Michel Rivier
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR042625A1 publication Critical patent/AR042625A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/66—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and singly-bound oxygen atoms, bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Su utilización en composiciones farmacéuticas destinadas a un uso en medicina humano o veterinaria (en dermatología, así como en el ámbito de las enfermedades cardiovasculares, de las enfermedades inmunitarias y/o de las enfermedades relacionadas con el metabolismo de los lípidos), o también en composiciones cosméticas. Reivindicación 1: Compuestos caracterizado porque responden a la fórmula (1), en la cual: R1 representa un radical de resto de grupo de fórmula (2), R4, R5, V, W e Y tienen las significaciones dadas adelante; R2 representa un átomo de hidrógeno, un átomo de halógeno, un radical alquilo C1-12, un radical hidroxilo, un radical alcoxi C1-7, un radical poliéter, un radical nitro, o un radical amino que puede ser eventualmente sustituido por uno o varios radicales alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo o un radical heterocíclico; R3 representa: un radical -(CH2)t-(N-R15)u-(C(O, N)2R16, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico o un radical 9-fluoronilmetilo, t, u , z R15 y R16 tienen las significaciones dadas adelante; R4 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico; R5 representa: un radical O-(CH2)n-R6, un radical NR'-(CH2)n-R14, un radical hidroxilo, un radical alcoxi C1-7, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico, el radical de fórmula (3), R6, R14, R', R'' y n tienen las significaciones dadas adelante; R' representa un átomo de hidrógeno, un radical alquilo C1-12, un radical hidroxilo, un radical arilo, un radical aralquilo, un radical heteroarilo o un radical heterocíclico; R'' representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico o un radical (CH2)n-R6; R6 y n tienen las significaciones dadas adelante; R6 representa un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico, el radical NH-CO-R7, el radical NH-CO-O-R, o el radical CH-R7-R6; R7 y R8 tienen las significaciones dadas adelante; n puede tomar los valores 1, 2 ó 3; R7 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo o un radical heterocíclico; R8 representa un átomo de hidrógeno o un radical alquilo C1-3; X representa un átomo de oxígeno, de azufre, un radical metileno (CH2) o NR9; R9 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical aralquilo; A representa un enlace de estructura: a) -(CH2)m-(N-R10)p-(CO)q-(D)r-, b) -(CH2)m-(N-R10)p-(CS)q-(D)r-, donde D, r, q, p, m tienen las significaciones dadas adelante; R10 tienen las significaciones dadas adelante; D representa un átomo de oxígeno, de azufre, un radical -NR11 o un radical CH2; R11 tiene la significación dada adelante; m, p, q y r, idénticos o diferentes, pueden tomar los valores 0 ó 1; R10 y R11, pueden ser idénticos o diferentes y representan un átomo de hidrógeno o un radical alquilo C1-12; V representa un átomo de oxígeno, de azufre o de nitrógeno; el átomo e nitrógeno está enlazado a un átomo de hidrógeno o a un radical alquilo C1-6; W representa un átomo de nitrógeno o un radical C-R12; R12 tiene las significaciones dadas adelante; Y representa un átomo de nitrógeno o un átomo de carbono; R12 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico; R13 representa un átomo de hidrógeno o de halógeno; R14 representa un radical heterocíclico; R15 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico; t, u y z, idénticos o diferentes, pueden tomar los valores de 0 a 4; R16 representa un átomo de hidrógeno, un radical alquilo C1-12, un radical arilo, un radical aralquilo, un radical heteroarilo, un radical heterocíclico, el radical NHCOR7, el radical NHCOOR7 o el radical NR7-R8; R7 y R8 tienen las significaciones dadas precedentemente, y cuando m representa 0, entonces q representa 1 y R10 representa un radical alquilo C1-12; y los isómeros ópticos y geométricos de dichos compuestos de fórmula (1) así como sus sales.
ARP030104594A 2002-12-12 2003-12-12 Compuestos moduladores de los receptores de tipo ppar gamma AR042625A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0215751A FR2848553B1 (fr) 2002-12-12 2002-12-12 Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques

Publications (1)

Publication Number Publication Date
AR042625A1 true AR042625A1 (es) 2005-06-29

Family

ID=32338740

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104594A AR042625A1 (es) 2002-12-12 2003-12-12 Compuestos moduladores de los receptores de tipo ppar gamma

Country Status (4)

Country Link
CN (1) CN1723193A (es)
AR (1) AR042625A1 (es)
FR (1) FR2848553B1 (es)
ZA (1) ZA200504263B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2862870A1 (fr) * 2003-12-01 2005-06-03 Galderma Res & Dev Utilisation d'activateurs de recepteurs ppar en cosmetique et dermatologie.
KR20070047308A (ko) * 2004-08-17 2007-05-04 갈데르마 리써어치 앤드 디벨로프먼트 Ｐｐａｒ 유형 수용체를 활성화시키는 신규 이방향족화합물, 및 미용 또는 약학적 조성물에서의 그의 용도
CA2587545C (en) * 2004-11-19 2013-10-22 Galderma Research & Development, S.N.C. Novel compounds that modulate ppar.gamma. type receptors, and use thereof in cosmetic or pharmaceutical compositions
FR2878247B1 (fr) 2004-11-19 2008-10-03 Galderma Res & Dev Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
EP1971322A2 (en) * 2005-12-13 2008-09-24 The Procter & Gamble Company Personal care compositions comprising ppar. gamma. antagonists
CN104611645B (zh) * 2014-12-29 2018-09-21 芜湖金龙模具锻造有限责任公司 一种耐高温合金模具钢

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739169A (en) * 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
FR2812876B1 (fr) * 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques

Also Published As

Publication number Publication date
FR2848553B1 (fr) 2007-03-30
FR2848553A1 (fr) 2004-06-18
ZA200504263B (en) 2006-02-22
CN1723193A (zh) 2006-01-18

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