AR028740A1 - Procedimiento para la preparacion de pirazolopirimidinonas - Google Patents
Procedimiento para la preparacion de pirazolopirimidinonasInfo
- Publication number
- AR028740A1 AR028740A1 ARP010102935A ARP010102935A AR028740A1 AR 028740 A1 AR028740 A1 AR 028740A1 AR P010102935 A ARP010102935 A AR P010102935A AR P010102935 A ARP010102935 A AR P010102935A AR 028740 A1 AR028740 A1 AR 028740A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- pirazolopirimidinones
- procedure
- preparation
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporciona un procedimiento para la produccion de un compuesto de formula general 1 en la que A, R1, R2, R3 y R4 tienen los significados dados en la descripcion, procedimiento que comprende la reaccion de un compuesto de formula 2 en la que R2 es un grupo sustituible por un aminopirazol, con un compuesto de formula 3 donde los sustituyentes de los compuestos formulas 2 y 3 poseen los significados dados en la descripcion. Se proporcionan también el compuesto intermediario 2 segun lo antes mencionado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0015472A GB0015472D0 (en) | 2000-06-22 | 2000-06-22 | Novel process for the preparation of pyrazolopyrimidinones |
GB0105857A GB0105857D0 (en) | 2001-03-09 | 2001-03-09 | Novel process for the preparation of pyrazolopyrimidinones |
Publications (1)
Publication Number | Publication Date |
---|---|
AR028740A1 true AR028740A1 (es) | 2003-05-21 |
Family
ID=26244540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010102935A AR028740A1 (es) | 2000-06-22 | 2001-06-20 | Procedimiento para la preparacion de pirazolopirimidinonas |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1292586B1 (es) |
JP (1) | JP2004501142A (es) |
KR (1) | KR100525698B1 (es) |
CN (1) | CN100338047C (es) |
AP (1) | AP2001002194A0 (es) |
AR (1) | AR028740A1 (es) |
AT (1) | ATE272626T1 (es) |
AU (2) | AU2001262597B2 (es) |
BR (1) | BR0111581A (es) |
CA (1) | CA2411961C (es) |
CZ (1) | CZ20024176A3 (es) |
DE (1) | DE60104691T2 (es) |
DK (1) | DK1292586T3 (es) |
DO (1) | DOP2001000190A (es) |
ES (1) | ES2223863T3 (es) |
HK (1) | HK1054926A1 (es) |
HU (1) | HUP0301183A3 (es) |
IL (1) | IL153532A0 (es) |
MX (1) | MXPA02012884A (es) |
MY (1) | MY124903A (es) |
PA (1) | PA8519801A1 (es) |
PE (1) | PE20020105A1 (es) |
PL (1) | PL359651A1 (es) |
PT (1) | PT1292586E (es) |
SV (1) | SV2002000503A (es) |
TN (1) | TNSN01093A1 (es) |
TR (1) | TR200401983T4 (es) |
WO (1) | WO2001098284A1 (es) |
YU (1) | YU93902A (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2310144B1 (es) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5. |
WO2009082845A1 (en) * | 2007-12-28 | 2009-07-09 | Topharman Shanghai Co., Ltd. | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
CN101747282A (zh) * | 2008-12-10 | 2010-06-23 | 上海特化医药科技有限公司 | 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途 |
US20120190849A1 (en) | 2009-08-07 | 2012-07-26 | Ranbaxy Laboratories Limited | Processes for the preparation of vardenafil |
US8981084B2 (en) | 2010-01-13 | 2015-03-17 | Tempero Pharmaceuticals, Inc. | Oxadiazole HDAC inhibitors |
MX2010006227A (es) | 2010-06-07 | 2011-12-14 | World Trade Imp Exp Wtie Ag | Nuevos derivados 1,4-diazepanos, inhibidores de pde-5. |
FR2970967B1 (fr) | 2011-01-27 | 2013-02-15 | Pf Medicament | Derives de type azaindazole ou diazaindazole comme medicament |
EP2689779A1 (en) | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk |
EP2689778A1 (en) | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindoles or diazaindoles for treating pain |
WO2018080859A1 (en) * | 2016-10-24 | 2018-05-03 | E. I. Du Pont De Nemours And Company | Fungicidal oxadiazoles |
AR116558A1 (es) * | 2018-10-01 | 2021-05-19 | Pi Industries Ltd | Oxadiazoles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
EP1002798A1 (en) * | 1998-11-20 | 2000-05-24 | Orchid Chemicals & Pharmaceuticals Ltd. | An improved process for preparing a therapeutically active pyrazolopyrimidinone derivative |
-
2001
- 2001-06-11 AU AU2001262597A patent/AU2001262597B2/en not_active Ceased
- 2001-06-11 AU AU6259701A patent/AU6259701A/xx active Pending
- 2001-06-11 DK DK01936737T patent/DK1292586T3/da active
- 2001-06-11 TR TR2004/01983T patent/TR200401983T4/xx unknown
- 2001-06-11 MX MXPA02012884A patent/MXPA02012884A/es active IP Right Grant
- 2001-06-11 CN CNB018114814A patent/CN100338047C/zh not_active Expired - Fee Related
- 2001-06-11 BR BR0111581-2A patent/BR0111581A/pt not_active IP Right Cessation
- 2001-06-11 KR KR10-2002-7017548A patent/KR100525698B1/ko not_active IP Right Cessation
- 2001-06-11 IL IL15353201A patent/IL153532A0/xx unknown
- 2001-06-11 PT PT01936737T patent/PT1292586E/pt unknown
- 2001-06-11 CA CA002411961A patent/CA2411961C/en not_active Expired - Fee Related
- 2001-06-11 WO PCT/IB2001/001050 patent/WO2001098284A1/en active IP Right Grant
- 2001-06-11 CZ CZ20024176A patent/CZ20024176A3/cs unknown
- 2001-06-11 YU YU93902A patent/YU93902A/sh unknown
- 2001-06-11 AP APAP/P/2001/002194A patent/AP2001002194A0/en unknown
- 2001-06-11 HU HU0301183A patent/HUP0301183A3/hu unknown
- 2001-06-11 AT AT01936737T patent/ATE272626T1/de not_active IP Right Cessation
- 2001-06-11 JP JP2002504240A patent/JP2004501142A/ja active Pending
- 2001-06-11 DE DE2001604691 patent/DE60104691T2/de not_active Expired - Fee Related
- 2001-06-11 ES ES01936737T patent/ES2223863T3/es not_active Expired - Lifetime
- 2001-06-11 EP EP01936737A patent/EP1292586B1/en not_active Expired - Lifetime
- 2001-06-11 PL PL01359651A patent/PL359651A1/xx not_active Application Discontinuation
- 2001-06-15 PA PA20018519801A patent/PA8519801A1/es unknown
- 2001-06-15 DO DO2001000190A patent/DOP2001000190A/es unknown
- 2001-06-19 MY MYPI20012889 patent/MY124903A/en unknown
- 2001-06-20 AR ARP010102935A patent/AR028740A1/es active IP Right Grant
- 2001-06-20 PE PE2001000599A patent/PE20020105A1/es not_active Application Discontinuation
- 2001-06-21 SV SV2001000503A patent/SV2002000503A/es not_active Application Discontinuation
- 2001-06-21 TN TNTNSN01093A patent/TNSN01093A1/fr unknown
-
2003
- 2003-09-30 HK HK03107037A patent/HK1054926A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |