AR036000A1 - Proceso para la preparacion de derivados de indol y novedosos intermediarios - Google Patents

Proceso para la preparacion de derivados de indol y novedosos intermediarios

Info

Publication number
AR036000A1
AR036000A1 ARP010102482A ARP010102482A AR036000A1 AR 036000 A1 AR036000 A1 AR 036000A1 AR P010102482 A ARP010102482 A AR P010102482A AR P010102482 A ARP010102482 A AR P010102482A AR 036000 A1 AR036000 A1 AR 036000A1
Authority
AR
Argentina
Prior art keywords
preparation
formula
novedous
intermediaries
indol derivatives
Prior art date
Application number
ARP010102482A
Other languages
English (en)
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of AR036000A1 publication Critical patent/AR036000A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Abstract

Un proceso para la preparación de los compuestos de la fórmula (1) en la cual R1 es alquilo C1-6 y X es hidrógeno, un radical hidrocarburo o un catión, en el cual se reduce un compuesto de la fórmula (2) en el cual R1 es como se lo definiera anteriormente y R2 es hidrógeno o un radical hidrocarburo, se hace reaccionar el compuesto resultante de la fórmula (3) con un compuesto que introduce un radical de fórmula -CH2-COOR3, en la cual R3 tiene los significados citados anteriormente para R2, y se reduce y, optativamente, se hidroliza el compuesto resultante de la fórmula (4).
ARP010102482A 2000-05-26 2001-05-24 Proceso para la preparacion de derivados de indol y novedosos intermediarios AR036000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00810460 2000-05-26

Publications (1)

Publication Number Publication Date
AR036000A1 true AR036000A1 (es) 2004-08-04

Family

ID=8174725

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102482A AR036000A1 (es) 2000-05-26 2001-05-24 Proceso para la preparacion de derivados de indol y novedosos intermediarios

Country Status (9)

Country Link
US (2) US6743926B2 (es)
EP (1) EP1284964A1 (es)
JP (1) JP2003535077A (es)
CN (1) CN1217930C (es)
AR (1) AR036000A1 (es)
AU (1) AU2001274049A1 (es)
CA (1) CA2407862A1 (es)
IL (1) IL152580A0 (es)
WO (1) WO2001092223A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092223A1 (en) * 2000-05-26 2001-12-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives and intermediates of the process
PT1404642E (pt) * 2001-07-06 2010-03-29 Basf Se Processo para a preparação de derivados do ácido 7-amino sin 3,5-dihidroxi heptanoico, intermediários respectivos e métodos para a sua preparação
CA2455842A1 (en) * 2001-08-22 2003-03-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives
GB0204129D0 (en) * 2002-02-21 2002-04-10 Novartis Ag Process for the manufacture of organic compounds
US20060035941A1 (en) * 2002-06-13 2006-02-16 Guang-Pei Chen Calcium salts of indole derived statins
US6951877B2 (en) * 2002-07-19 2005-10-04 Aryx Therapeutics, Inc. Materials and methods for treating hypercholesterolemia
US20060105441A1 (en) * 2003-03-13 2006-05-18 Reinhold Ohrlein Process for the preparation of indole derivatives by enzymatic acylation
JP4269902B2 (ja) 2003-08-27 2009-05-27 住友化学株式会社 芳香族不飽和化合物の製造方法
US7432380B2 (en) * 2003-10-16 2008-10-07 Ciba Specialty Chemicals Corp. Crystalline form of Fluvastatin sodium
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
US7795451B2 (en) * 2005-02-11 2010-09-14 Jubilant Organosys Limited Polymorphic forms of fluvastatin sodium and process for preparing the same
CN1978428B (zh) * 2005-12-05 2012-07-04 四川抗菌素工业研究所有限公司 一种(3r，5s）-氟伐他汀的制备方法
ATE431818T1 (de) * 2006-04-20 2009-06-15 Italiana Sint Spa Verfahren zur herstellung von fluvastatin-natrium
CN104250222A (zh) * 2013-06-27 2014-12-31 上海朴颐化学科技有限公司 一种氟伐醇酮制备工艺改进方法
CN103342721B (zh) * 2013-07-15 2016-04-13 凯莱英医药集团（天津）股份有限公司 一种制备氟伐他汀关键中间体的方法
JP6649263B2 (ja) * 2014-10-10 2020-02-19 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204253B (en) 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
US4677211A (en) * 1984-06-29 1987-06-30 Sandoz Pharmaceuticals Corp. Preparation of lactones
US4870199A (en) * 1986-04-30 1989-09-26 Sandoz Pharm. Corp. Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
EP0244364A3 (en) 1986-04-30 1992-04-01 Sandoz Ag Preparation of olefinic compounds
MY105067A (en) * 1988-10-13 1994-07-30 Novartis Ag Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof.
DK181190D0 (da) 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
PT1064243E (pt) * 1998-03-18 2003-03-31 Ciba Sc Holding Ag Reaccoes de acoplamento com catalisadores de paladio
WO2001092223A1 (en) * 2000-05-26 2001-12-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives and intermediates of the process

Also Published As

Publication number Publication date
WO2001092223A1 (en) 2001-12-06
US20030166946A1 (en) 2003-09-04
AU2001274049A1 (en) 2001-12-11
CA2407862A1 (en) 2001-12-06
US20040176614A1 (en) 2004-09-09
CN1217930C (zh) 2005-09-07
IL152580A0 (en) 2003-05-29
JP2003535077A (ja) 2003-11-25
US6743926B2 (en) 2004-06-01
EP1284964A1 (en) 2003-02-26
CN1430604A (zh) 2003-07-16

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